Substituted pyridine compounds

ABSTRACT

Disclosed herein are herbicidal pyridine compounds substituted at the 2- or 6-position with an OR2 moiety where R2 is hydrogen, lower alkyl, halomethyl, lower cyanoalkyl, alkenyl or alkynyl, as well as herbicidal compositions and herbicidal use of these compounds.

This is a divisional of application Ser. No. 08/339,994, filed Nov. 15, 1994 now U.S. Pat. No. 5,512,536 which is a divisional of U.S. Ser. No. 08/045,154, filed Apr. 12, 1993, now U.S. Pat. No. 5,391,540; which is a divisional of U.S. Ser. No. 07/871,525, filed Apr. 20, 1992, now U.S. Pat. No. 5,228,897; which is a divisional of U.S. Ser. No. 07/660,480, filed Feb. 25, 1991, now U.S. Pat. No. 5,125,956.

This invention relates to a new class of substituted pyridinecarboxylic acid derivatives having a wide range of activity as herbicides.

Pyridine derivatives have, for many years, been investigated for use in biological sciences. For example, 2,6-bis(trifluoromethyl)-4-pyridinols have been found useful as herbicides and fungicides as disclosed in U.S. Pat. No. 3,748,334. Such compounds are characterized by substitution in the 4-position by a hydroxy radical. In addition to the hydroxy radical, the pyridine nucleus may also be substituted with bromo, chloro or iodo radicals. Trifluoromethyl pyridine derivatives have also been disclosed in U.S. Pat. Nos. 2,516,402 and 3,705,170 wherein the nucleus is further substituted by halogens as well as numerous other substituents. Some of these compounds are also noted to be useful as herbicides.

Also known because of their fungicidal activity are 4-substituted 2,6-dichloro-3,5-dicyanopyridines wherein the 4-position is substituted with alkyl, phenyl, naphthyl or pyridyl groups. Such compounds are disclosed in U.S. Pat. No. 3,284,293, while similar compounds are disclosed in U.S. Pat. No. 3,629,270 wherein the 4-position is substituted with a heterocyclic group wherein the hetero atom is oxygen or sulfur.

In EPO patent 44,262 there are disclosed 2,6-dialkyl-3-phenylcarbamyl-5-pyridinecarboxylates and 5-cyano-compounds useful as herbicides. There is no disclosure of the 2-haloalkyl radicals or any substitution in the 4-position of the pyridine ring.

The pyridine derivatives have also received attention in the search for new herbicides and have been reported in U.S. Pat. Nos. 1,944,412, 3,637,716, and 3,651,070. All of these patents disclose polyhalo derivatives of dicarboxypyridines. All have in common the direct substitution on a ring carbon by a halogen in the 3- and 5-positions while the 2- and 6-positions are occupied by carboxylate groups. The 4-position is open to substitution by a wide range of materials including halogens, hydroxy radicals, alkoxy, and carboxyl groups. Such compounds have found utilization as herbicides, bactericides, and fungicides. When the 4-position is occupied by a silver salt, U.S. Pat. No. 1,944,412 discloses that such compounds have been utilized in the production of X-ray pictures with intravenous injection of such compounds.

Pyridinedicarboxylate compounds useful as herbicides are described in U.S. Pat. No. 4,692,184. These compounds have fluorinated methyl groups at the 2- and 6-positions and carboxylic acid derivative at the 3- and 5-positions.

Other pyridinedicarboxylate compounds including pyrazole amides are disclosed in U.S. Pat. No. 4,698,093. U. S. Pat. Nos. 4,066,438 and 4,180,395 disclose various herbicidal polyhalo substituted pyridyloxy compounds.

BRIEF DESCRIPTION OF THE INVENTION

It is an object of this invention to provide herbicidal methods and compositions utilizing the novel pyridines of this invention.

The novel compounds of this invention are useful as herbicides or intermediates which can be converted to herbicides and are represented by the generic formula ##STR1## wherein: R₁ is fluorinated methyl, chlorofluorinated methyl or fluorinated ethyl;

R₂ is hydrogen, lower alkyl, trichloromethyl, lower cyanoalkyl, alkenyl, or alkynyl;

R is C₁ -C₆ straight or branched alkyl, haloalkyl, alkylthioalkyl, alkoxyalkyl, carboxyalkyl, C₃ -C₄ cycloalkyl, or cyclopropylmethyl;

X and Y are independently selected from

a) ##STR2## where Z₁ is oxygen or NR₃ where R₃ is lower alkyl and where Z is hydrogen; halogen; hydroxy; alkoxy; haloalkoxy; alkynyloxy; alkylthio; NR₄ R₅ where R₄ and R₅ are independently hydrogen or lower alkyl; acetylamino; hydroxyalkyl; haloalkyl; 1-pyrazolyl; 1-imidazolyl; 1,2,4-triazolyl; 1-pyrrolidinyl; 1-piperidinyl; 1-azetidinyl; 4-morpholinyl; 4-thiomorpholinyl; 3-thiazolidinyl; 1-aziridinyl; hexahydro-1-azepinyl; alkoxymethyleneamino; and 2-isoxazolidinyl; or

b) 1-pyrrolyl; cyano; 4,5-dihydro-2-oxazolyl; NR₆ R₇ where R₆ and R₇ are independently hydrogen or hydroxyalkyl; 4,5-dihydro-2-thiazolyl; alkoxymethyleneamino; dialkylaminomethyleneamino; alkylthiomethylenamino; tetrahydro-4-methylene-5-oxo-2-furanyl; 1,3-dioxolan-2-yl; 1,3-dithian-2-yl; (2-hydroxyalkyl)iminomethyl; halo-2-(haloalkyl)iminomethyl; 5,6-dihydro-4H-1,3-thiazin-2-yl; 5,6-dihydro-4H-1,3-oxazin-2-yl; 1,3,4-oxadiazol-2-yl; 1,3-dioxan-2-yl; 5-oxazolyl; hydroxyalkyl; 2-oxazolyl; halo-1-oxoalkylamino; (dihydro-2(3H)-furanylidene)amino; 1,3-oxathiolan-2-yl; 4-oxo-1,3-dioxolan-2-yl; 3-oxathiolan-2-yl; 3,3-dioxo-1,3-oxathiolan-2-yl; and 2-thiazolyl; or

c) the above-mentioned heterocycles substituted by one or more substituents selected from lower alkyl; halo; nitro; acetylamino; amino; and cyano.

The term "lower" used herein for lower alkyl, lower alkoxy or like group means a group containing 1-7 carbon atoms in straight or branched chain form. Specifically, the lower alkyl group may be methyl, ethyl, propyl, isopropyl, butyl, isobutyl, pentyl, isopentyl or hexyl; the lower alkoxy group may be methoxy, ethoxy, propoxy, isopropoxy; the lower alkylthio group may be methylthio, ethylthio, propylthio, isopropylthio, butylthio or pentylthio. The lower alkenyl or lower alkynyl group have 3 to 7 carbon atoms and may be vinyl, allyl, isopropenyl, 2-butenyl, 1,3 butadienyl, 2-pentenyl, 1,4-pentadienyl, 1,6-heptadienyl, 1-hexenyl, ethynyl,2-propynyl, etc.

The term "halo" or cognates thereof include chlorine, bromine, fluorine and iodine.

Examples of "cycloalkyl" as used herein include cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl.

Examples of "lower haloalkyl" as used herein include chloromethyl, bromomethyl, dichloromethyl, dibromomethyl, trifluoromethyl and the like.

Examples of "lower alkoxyalkyl" as used herein include methoxymethyl, ethoxymethyl, propoxymethyl, butoxymethyl and the like.

Examples of "lower alkylthioalkyl" as used herein include methylthiomethyl, ethylthiomethyl, methylthioethyl, ethylthioethyl and the like.

The term "cycloalkylalkyl" means a C₁ -C₂ alkyl group substituted with a C₃ -C₆ cycloalkyl group, such as cyclopropylmethyl, cyclopropylethyl, cyclobutylmethyl, cyclopentylethyl, and so forth.

The terms "fluorinated methyl", "chlorinated methyl", and "chlorofluorinated methyl" mean methyl radicals wherein one or more of the three hydrogen atoms have been replaced by a fluorine atom, a chlorine atom, or a fluorine atom and a chlorine atom, respectively.

DETAILED DESCRIPTION OF THE INVENTION

The novel herbicidal derivative and their compounds of this invention are readily prepared by reaction as illustrated in the following working examples.

As used throughout the specification, including the examples, the following abbreviations have the following meanings:

THF--tetrahydrofuran

HPLC--high pressure liquid chromatography

RT--room temperature

DBU--1,8-diazabicyclo-[5.4.0]-undec-7-ene

EtOAc--ethyl acetate

DME--dimethoxyethane

t-BuOK--potassium t-butoxide

DMF--N,N-dimethylformamide

RBF--round bottom flask

GC--gas chromatography

d--day(s)

nD--index of refraction at 25° C.

v/v--volume/volume

kp--kiloPascal(s)

c--cyclo

Me--methyl

Et--ethyl

Ac--acetyl

TFAA--trifluoroacetic anhydride

HMPA--hexamethylphosphoric triamide

The present invention is merely illustrated by the following working examples but obviously is not limited thereto. All percentages are given on a weight/weight basis unless otherwise indicated.

In some examples, the reaction of selected ketoesters, aldehydes, and cyanoacetamide in the presence of a base was used to form several dihydropyridone precursors as illustrated in the following scheme. ##STR3##

In some other examples, the reaction of an aldehyde with cyanacetamide was used to form an alkylidene which was further reacted with a ketoester to give additional dihydropyridine precursors as illustrated in the following scheme. ##STR4##

EXAMPLE 1

This example illustrates the preparation of 5-pyridinecarboxylic acid, 3-(aminocarbonyl)-1,2,3,4-tetrahydro-4-(2-methylpropyl)-2-oxo-6-(trifluoromethyl)-, methyl ester.

Methyl trifluoroacetoacetate (170 g, 1.0 mol), isovaleraldehyde (86 g, 1.0 mol) and cyanoacetamide (84 g, 1.0 mol) were placed in a 3-liter round bottom flask fitted with a thermometer and water condenser. To this mixture was added 500 mL ethanol followed by 20 mL piperidine, and the resulting mixture was heated at reflux for 4 h after which time all the cyanoacetamide had dissolved. The reaction mixture was cooled to room temperature, 50 mL concentrated hydrochloric acid added, and the volatiles removed by rotary evaporator until a thick slurry formed. This slurry was filtered through a Buchner funnel overnight (without a solvent wash) to separate the solid product from an oily impurity. The crude product was dampened with ether to facilitate its removal from the funnel, then mechanically stirred with 200 mL ether until a uniform thick slurry was obtained. The slurry was filtered through a Buchner funnel and the filter cake washed with a minimum amount of cold ether, broken into fine pieces and dried in air. Yield was 175 g (54%) of the intermediate as a white solid.

mp 153°-155° C. Anal: Calcd for C₁₃ H₁₇ F₃ N₂ O₄ : C, 48.45; H, 5.32; N, 8.69. Found: C, 48.58; H, 5.35; N, 8.69.

EXAMPLE 2

This example illustrates the preparation of 5-pyridinecarboxylic acid, 3-(aminocarbonyl)-1,2,3,4-tetrahydro-4-(2-methylpropyl)-2-oxo-6-(pentafluoroethyl)-, ethyl ester.

A mixture of ethyl pentafluoropropionylacetate (234 g, 1.0 mol), isovaleraldehyde (86 g, 1.0 mol), cyanoacetamide (84 g, 1.0 mol) and piperidine (20 mL) were heated at reflux in 500 mL ethanol for 20 h, after which time the reaction mixture was cooled in an ice bath and the solid product filtered and washed with a minimum amount of ether. On drying, 232 g (60%) of the product was obtained as a white solid, mp 154°-157° C.

EXAMPLE 3

This example illustrates the preparation of 5-pyridinecarboxylic acid, 3-(aminocarbonyl)-1,2,3,4-tetrahydro-4-(cyclopropylmethyl)-2-oxo-6-trifluoromethyl-, methyl ester, was prepared as follows. A mixture of cyclopropylacetaldehyde (2.52 g, 30 mmol), methyl trifluoroacetoacetate (5.10 g, 30 mmol), cyanoacetamide (2.52 g, 30 mmol) and piperidine (0.6 g) was heated at reflux in 30 mL 1,2-dichloroethane for 3.5 h, after which time the reaction mixture was cooled to room temperature and volatiles removed via rotory evaporator. The residue was purified by chromatotron, eluting with 8:1 hexane:ethyl acetate to remove impurities, followed by ethyl acetate to elute the product. Yield of the product was 4.4 g (46%) of a white sticky solid.

EXAMPLE 4

This example illustrates the preparation of butenamide, 2-cyano.

A mixture of cyanoacetamide (84 g, 1.0 mol), acetaldehyde (44 g, 1.0 mol) and piperidine (3 mL) was stirred in glacial acetic acid (150 mL) at room temperature for 21 h. The reaction mixture was then poured into 1000 mL water and extracted with three 300 mL portions of ethyl acetate. The combined ethyl acetate extracts were dried with anhydrous magnesium sulfate, filtered and solvent removed. To the residue was added ether (50 mL) and the resulting slurry was filtered to give 22.8 g (21%) of product as a white solid. A portion was recrystallized from methanol to give a white solid, mp 114°-146° C.

EXAMPLE 5

This example illustrates the preparation of 2-hexenamide, 2-cyano-5-methyl.

To a 22-L round bottomed flask was added 2.9 L of glacial acetic acid, cyanoacetamide (2229 g, 26.51 mol) and isovaleraldehyde (2387 g, 27.72 mol). The solution was stirred while a mixture of piperidine (72.3 g) in 600 ml of glacial acetic acid was added over the course of 3 h. The reaction temperature, initially at 19° C., rose to 26° C. during the course of the addition with no external cooling. The reaction mixture was allowed to stand at RT overnight, during which time a small amount of white solid formed in solution. The reaction mixture was split in half, and each half was extracted by adding 6 L of H₂ O and 5 L of CH₂ Cl₂. The layers were separated, and the aqueous layer was extracted an additional time with 2 L of CH₂ Cl₂. The combined organic layers were extracted with 6 L of H₂ O, separated and dried over MgSO₄ then the solvents were removed by rotary evaporation to yield a yellow solid. The yellow solid was placed in a bucket and stirred with ether followed by filtration to yield 2954 g (73%) of a white solid. The filtrate was reduced in volume by 1/3, then placed in a freezer to crystallize an additional 194 g (5%) of the desired product (total yield: 78%) as an uncharacterized mixture of E/Z isomers: mp 97°-98° C.

EXAMPLE 6

This example illustrates the preparation of butenamide, 2-cyano-4-cyclopropyl.

A mixture of cyclopropylacetaldehyde (1.75 g, 20.8 mmol), cyanoacetamide (1.68 g, 20 mmol), and 5 drops piperidine was stirred in 25 mL glacial acetic acid at room temperature for 5d, after which time a stream of nitrogen was passed over the resulting solution overnight. The solid yellow residue was dissolved in 100 mL ethyl acetate, washed with three 50-mL portions of water, dried with anhydrous magnesium sulfate, filtered, and solvent removed to give a yellow solid which was used without further purification. Yield of product was 2.0 g (67%).

EXAMPLE 7

This example illustrates the preparation of Compound 86, namely, 3,5-pyridinedicarboxylic acid, 2-methoxy-4-methyl-6-(trifluoromethyl)-, dimethyl ester. A mixture of the product of Example 4 (55 g, 0.5 mol), methyl trifluoroacetoacetate (85 g, 0.5 mol), and 10 mL piperidine in 300 mL 1,2-dichloroethane was refluxed for 22 h. The resulting solution was cooled in an ice bath to precipitate the product, which was filtered and washed with a small portion of cold 1,2-dichloroethane. Additional product was obtained by treating the filtrate with ether. Total yield was 80.1 g (57%) of white solid. To a solution of this material (14 g, 50 mmol) in 75% sulfuric acid (100 mL) cooled in an ice bath was added sodium nitrite (20 g, 290 mmol) in water (20 mL) over 20 min. After the addition was complete, the reaction mixture was stirred for an additional 20 min, after which time 500 g ice was added and the resulting mixture stirred at ambient temperature for 2 h. The crude acid pyridone was filtered and dried in air to give 6.8 g of a yellow solid. This material was dissolved in DMF (50 mL) and stirred with potassium carbonate (10 g, 72 mmol) and methyl iodide (10 mL, 161 mmol) at room temperature for 40 h. The resulting mixture was poured into 100 mL water and extracted with two 100 mL portions of ether. The combined ether extracts were dried with anhydrous magnesium sulfate, filtered and solvent removed to give the crude product which was purified by chromatotron, eluting with 8:1 hexane:ethyl acetate. Yield was 5.6 g (37%) of a clear oil which solidified on standing, mp 36°-37° C.

EXAMPLE 8

This example illustrates another route for the preparation of the product of Example 1.

To a 22-L RBF was added product of Example 5 (2738 g, 17.99 mol), methyl trifluoroacetoacetate (3059.8 g, 17.99 mol) and 12.5 L of 1,2-dichloroethane. To the reaction mixture, which was stirring at RT, piperidine (270 g) was added dropwise over the course of 40 min. After all of the piperidine was added, a small exotherm was noted that raised the reaction temperature from 29° C. to 55° C. in 30 minutes. At this point the reaction was gently refluxed for 4 h and then stirred at room temperature overnight. The following morning, a white solid had precipitated from the yellow reaction mixture. The solid was collected by filtration, washed with portions of ether and then dried to yield 4885 g (84%) of a white solid: mp 154°-157° C.

The following additional four compounds were prepared in the manner of the foregoing examples with the indicated yields.

1. 5-pyridinecarboxylic acid, 3-(aminocarbonyl)-1,2,3,4-tetrahydro-4-(1-methylethyl)-2-oxo-6-(trifluoromethyl)-, methyl ester (41% yield).

2. 5-pyridinecarboxylic acid, 3-aminocarbonyl)-1,2,3,4-tetrahydro-4-cyclopropyl-2-oxo-6-(trifluoromethyl)-, methyl ester (74% yield).

3. 5-pyridinecarboxylic acid, 3-aminocarbonyl)-1,2,3,4-tetrahydro-4-cyclobutyl-2-oxo-6-(trifluoromethyl)-, methyl ester (62% yield).

4. 5-pyridinecarboxylic acid, 3-aminocarbonyl-1,2,3,4-tetrahydro-4-(2-methylpropyl)-2-oxo-6-(trifluoromethyl)-, ethyl ester (65% yield).

The reaction of dihydropyridones with nitrous acid was used to form hydroxypyridines in accordance with the following scheme: ##STR5##

EXAMPLE 9

This example illustrates the preparation of 3,5-pyridinedicarboxylic acid, 2-hydroxy-4-(2-methyl propyl)-6-(trifluoromethyl)-, 5-methyl ester.

To a 22-L round bottomed flask, equipped for cooling, was added water (1667 mL) and concentrated sulfuric acid (5 L). After the aqueous acid had cooled to 23° C., the product of Example 1 (1.0 kg, 3.1 mol) was added to the flask. After several minutes of stirring an even suspension of material formed. To the reaction mixture was added, dropwise over the course of 3 h, a solution of sodium nitrite (875 g, 12.68 mol) in 2.0 L of water. Cooling was applied as needed to maintain the reaction temperature below 50° C. Large volumes of a brown gas (nitrous oxide) were evolved and a large amount of foam was formed during the reaction. A white solid formed in solution after stirring at RT overnight. To the flask was added 10 L of water, cooling was applied to maintain the temperature below 20° C. The reaction mixture was filtered and the collected solid was washed with large amounts of water in a Buchner funnel. The product was dried to yield 927 g (93%) of a white solid: mp 131°-133° C.

EXAMPLE 10

This example illustrates the preparation of 3,5-pyridinedicarboxylic acid, 2-hydroxy-4-(2-methylpropyl)-6-(pentafluoroethyl)-, 5-ethyl ester and 3,5-pyridinedicarboxylic acid, 2-methoxy-4-(2-methylpropyl)-6-(pentafluoroethyl)-, 5-ethyl 3-methyl ester, the latter compound being Compound 11.

To a mechanically stirred solution of product of Example 2 (232 g, 0.60 mol) in 1500 mL 75% v/v sulfuric acid was added sodium nitrite (250 g, 3.62 mol) in 700 mL water over 3 h. The sodium nitrite solution was introduced below the surface of the reaction medium. Vigorous gas evolution occurred. Stirring was continued for 1 h after the addition was complete, after which time the reaction mixture was diluted with an equal volume of ice, filtered, and the crude product was washed with water. On drying, 217 g (94%) of a yellow solid was obtained.

A mixture of the thus-produced material (217 g), methyl iodide (120 mL), and potassium carbonate (240 g) was mechanically stirred in 1000 mL DMF at room temperature overnight. The reaction mixture was diluted with two volumes of water and extracted into a total of 3 L ether. The ether extracts were washed with 4N hydrochloric acid, dried with anhydrous magnesium sulfate, filtered and solvent removed to give the crude product, which was purified by column chromatography (SiO₂), eluting with 8:1 hexane:ethyl acetate. Yield of Compound 11 was 200 g (81%) of a light reddish-brown oil.

The reaction of pyridine acids with alcohols in the presence of acid was used to give certain esters.

EXAMPLE 11

This example illustrates the preparation of Compound 1, namely, dimethyl 2-hydroxy-4-(2-methylpropyl)-6-(trifluoromethyl)-3,5-pyridine dicarboxylate. A two liter round bottom flask was charged with 247 g (0.77 mole) of the product of Example 9 and one liter of methanol. Three drops of concentrated sulfuric acid were added and the solution was heated at reflux for 48 hours. The methanol was removed by rotary evaporation and the solid mass was dissolved in methylene chloride and washed with saturated aqueous sodium bicarbonate. The solution was dried with magnesium sulfate and the solvent was removed by rotary evaporation to give 119.63 g (50.5%) of an off-white solid, mp 80°-85° C.

Anal: Calcd for C₁₄ H₁₆ N₁ O₅ F₃ : C, 50.15; H, 4.81; N, 4.18. Found: C, 49.88; H, 4.73; N, 4.18.

The reaction of pyridines with alkyl halides in the presence of base was used to give certain pyridines of the present invention.

EXAMPLE 12

This example illustrates the preparation of Compound 2.

To a 22-L RBF was added the product of Example 9 (2368 g, 7.37 mol), 9 L of DMF and potassium carbonate (2230.3 g, 16.14 mol). The reaction mixture was cooled to 4° C. then iodomethane (935 mL, 15.47 mol) was added dropwise over the course of 3 h while maintaining the reaction temperature below 6° C. After the addition was complete the reaction was stirred at RT for 48 h. The reaction was split in half and each half was treated with 7 L of H₂ O and 3.5 L of CH₂ Cl₃. The aqueous layer was extracted a second time with 3 L of CH₂ Cl₂ and 1 L of H₂ O. The combined organic layers were dried over MgSO₄, filtered and removed by rotory evaporation to yield a red oil (2097.4 g) which by GC consisted of Compound 2 (81%), the N-methyl-2-pyridone (15.6%) and the starting acid (0.3%). The more mobile Compound 2 was separated from the N-methylated by-product by applying 1 kg of the reaction mixture to 1.5 kg of silica gel and eluting with hexane or 1% EtOAc/hexane. Compound 2 (1677 g, 65% yield, 99% pure) was isolated as a yellow oil.

EXAMPLE 13-16

The general procedure for the preparation of Compounds 9, 44, 48 and 63 was used as follows.

A mixture of the appropriate pyridone (1 eq), potassium carbonate (4 eq), and methyl iodide (2.2 eq) in DMF was mechanically stirred at room temperature for 16 h. The reaction mixture was diluted with water and the product extracted with ether (3×), dried (MgSO₄), filtered, and concentrated. The crude product was chromatographed eluting with 10% ethyl acetate in hexane to afford the desired product. Compound 9: yellow solid (17%) mp 96°-97° C. Compound 44: colorless oil (48%) nD: 1.4618. Compound 48: yellow oil (27%) nD: 1.4809. Compound 63: colorless oil (28%) nD: 1.4623.

The reaction of an imidate with an alkylidene in the presence of base, followed by aromatization was used to give compounds of the present invention.

EXAMPLE 17

This example illustrates the preparation of propenoic acid, 3-amino-3-methoxy-, methyl ester, used in preparation of compounds of the present invention. Hydrogen chloride was bubbled into a solution of methyl cyanoacetate (54.0 g, 0.54 mol), ether (21 g), and methanol (21.0 g, 0.60 mol) cooled in an ice/salt water bath. When the exotherm ceased, the cloudy reaction mixture was stoppered and placed in the refrigerator overnight. A viscous oil formed, which was dissolved in ether (200 mL) and vigorously stirred at 0° C. The solid precipitate was filtered and added to a mixture of saturated NaHCO₃ (150 mL) and ether (150 mL) vigorously stirred. The layers were separated and the aqueous layer was washed with ether (3×100 mL). The combined ether extracts were washed with water (1×100 mL), dried over magnesium sulfate, filtered and concentrated to a colorless oil. Vacuum distillation 45°-70° C. afforded 27.1 g (38%) of the desired product, mixed with starting material (61:39).

EXAMPLE 18

This example illustrates the preparation of Compound 3, namely, 3,5-pyridinedicarboxylic acid, 2-ethoxy-4-(2-methylpropyl)-6-(trifluoromethyl)-, 3-ethyl, 5-methyl ester, hydrate (1:0.4), used in the preparation of compounds of the present invention. Propenoic acid, 3-amino-3-ethoxy-, ethyl ester (100 g, 0.51 mol) was added to 2-hexenoic acid, 5-methy-2-(trifluoroacetyl)-, methyl ester (122.2 g, 0.51 mol) in 450 mL chloroform; an exotherm was observed. Triethylamine (catalytic amount) was added and the reaction mixture heated to reflux for 1 h, then concentrated to an oil (200 g). The crude product was heated to reflux in 400 mL trifluoroacetic anhydride overnight, then concentrated and washed with saturated NaHCO₃ (1×500 mL). The product was extracted with ether (3×200 mL), dried over magnesium sulfate, filtered and concentrated to an oil (220 g). The crude product (150 g, 0.40 mol) was refluxed in thionyl chloride (380 mL) for 3 h, then cooled, carefully added to ice water and extracted into ether (3×200 mL). The organic layer was dried over magnesium sulfate, filtered and concentrated. The resulting oil was purified by HPLC, eluting with 10% ethyl acetate in hexane to give 48 g (32%) of Compound 3 as a light yellow oil. The flush (EtOAc) was recovered to give 80 g (45%) 3-ethyl 5-methyl 2-hydroxy-4-(2-methylpropyl-6-(trifluoromethyl)-3,5-pyridinedicarboxylate.

EXAMPLES 19-22

The general procedure for the preparation of Compounds 4, 5, 7 and 23 was used as follows. The appropriate alkyl halide (1 eq) was added to a slurry of 3-ethyl 5-methyl 2-hydroxy-4-(2-methylpropyl)-6-(trifluoromethyl)-3,5-pyridinedicarboxylate (1 eq) and silver carbonate (0.5 equivalent) in hexane with stirring at room temperature in the dark. The reaction mixture was heated to reflux overnight, cooled, and filtered. The mother liquor was washed with saturated NaHCO₃ (1×), water (2×), dried over magnesium sulfate, filtered, and concentrated. The crude material was chromatographed to give the desired product.

EXAMPLES 23-26

Compounds 26, 29, 30 and 31 were prepared in accordance with the following scheme. ##STR6##

EXAMPLE 27

2-Hexenoic acid, 5-methyl-2-(chlorodifluoroacetyl)-, methyl ester, was prepared as follows. To a solution of methyl chlorodifluoroacetoacetate (200 g, 1.07 mol) and isovaleraldehyde (108.5 g, 1.26 mol) in 125 mL benzene was added 13.8 g glacial acetic acid and 3.91 g piperidine, resulting in an exotherm to ca 80° C. The reaction mixture was heated at reflux for 2.5 h with azeotropic removal of water, after which time solvent was distilled at atmospheric pressure and remaining volatiles removed by pumping at 1 torr (0.2 kp). Yield of product was 278 g (100%) of a clear red oil which was 88% pure by gas chromatographic analysis.

EXAMPLE 28

3,5-Pyridinedicarboxylic acid, 1,2-dihydro-6-(chlorodifluoromethyl)-4-(2-methylpropyl)-2-oxo-, 3-ethyl 5-methyl ester, was prepared as follows. To a solution of the product of Example 27 (67.3 g, 208 mmol) and ethyl 3-amino-3-ethoxypropenoate (30.1 g, 189 mmol) in 50 mL chloroform was added 5 mL triethylamine and the resulting mixture refluxed for 1 hour. The reaction mixture was cooled to room temperature, washed with 100 mL of 4N hydrochloric acid, and the organic layer dried with anhydrous magnesium sulfate, filtered and concentrated. To this residue was added 275 mL trifluoroacetic anhydride and the mixture heated at reflux for 21 h, after which time volatiles were removed via rotary evaporator. To the residue was added 250 mL thionyl chloride and the mixture heated at reflux for 16 h. The reaction mixture was cooled to room temperature, slowly poured onto 1000 mL ice, and extracted with two 500-mL portions of ether. The combined ether extracts were dried with anhydrous magnesium sulfate, filtered and concentrated to give a crude product which was purified by HPLC (10% hexane:ethyl acetate). Yield of product was 31.2 g (45%) as a yellow oil.

EXAMPLE 29

This example illustrates the preparation of Compound 29, namely, 3,5-pyridinedicarboxylic acid, 2-(chlorodifluoromethyl)-6-methoxy-4-(2-methylpropyl)-, 5-ethyl 3-methyl ester. A mixture of the product of Example 28 (31 g, 85 mmol), methyl iodide (5.3 mL, 85 mmol) and silver carbonate (17.53 g, 64 mmol) in 250 mL hexane was refluxed for 5 h in the dark. The reaction mixture was cooled to room temperature, filtered and the filtrate successively washed with saturated aqueous sodium bicarbonate (1×100 mL) and water (2×100 mL). The organic layer was dried with anhydrous magnesium sulfate, filtered, and concentrated to give the crude product which was purified by HPLC (5:1 hexane:ethyl acetate). Yield of Compound 29 was 22.2 g (69%) of colorless oil.

EXAMPLE 30

This example illustrates the preparation of 3-pyridinecarboxylic acid, 5-(chlorocarbonyl)-2-(chlorodifluoromethyl)-6-methoxy-4-(2-methylpropyl)-, methyl ester. Selective hydrolysis of Compound 29 was accomplished using the method described in Example 50. Acidification and extraction of the reaction mixture yielded a solid, which was washed with hot petroleum ether/ether solution to afford a 56% yield of product. Treatment of the crude monoacid with an equimolar amount of phosphorous pentachloride gave the desired acid chloride product in 85% yield.

EXAMPLE 31

This example illustrates the preparation of Compound 30, namely, 3,5-pyridinedicarboxylic acid, 2-(chlorodifluoromethyl)-6-methoxy-4-(2-methylpropyl)-, dimethyl ester. Product of Example 30 (8.0 g, 0.021 mol) was stirred in methanol (25 mL) overnight at room temperature, then concentrated, dissolved in ether (100 mL), and washed with water (3×100 mL). The organic phase was dried over magnesium sulfate filtered, and concentrated to an oil. Purification via HPLC, eluting with 2% ethyl acetate in hexane afforded 5.25 g (66%) Compound 30 as a yellow oil. nD: 1.4812

EXAMPLES 32 and 33

This illustrates the preparation of Compounds 26 and 31. 5% Palladium on carbon was placed in the reaction flask. Under a nitrogen atmosphere, the chlorodifluoropyridine (Compound 29 or Compound 30) (1 eq) in ethanol was carefully added, followed by triethylamine (1.1 eq). The reaction flask was placed on a Parr hydrogenator and heated at 60° C. overnight. The reaction mixture was filtered, and the mother liquor concentrated, dissolved in ether and washed with water (3×). The organic layer was dried over magnesium sulfate, filtered, and concentrated. The crude material was chromatographed to yield the desired difluoromethylpyridine.

EXAMPLE 34

This example illustrates the preparation of 3,5-pyridinedicarboxylic acid, 2-methoxy-4-(2-methyl propyl)-6-(trifluoromethyl). Compound 2 (70.9 g, 0.20 mol) was heated at reflux in 25% NaOH (500 mL) and methanol (250 mL) overnight, then cooled and concentrated. The residue was diluted with water (200 mL) and washed with ether (2×100 mL), which was discarded. The aqueous layer was acidified with concentrated HCl and extracted with ether (3×200 mL). The organic layer was dried over magnesium sulfate, filtered, and concentrated to give 60 g (93%) of the dicarboxylic acid product as a solid.

EXAMPLE 35

This example illustrates the preparation of 3,5-pyridinedicarbonyl chloride, 2-methoxy-4-(2-methyl propyl)-6-(trifluoromethyl). Phosphorus pentachloride (85.6 g, 0.40 mol) was added to the product of Example 34 (60.0 g, 0.19 mol) in carbon tetrachloride (450 mL) at 0° C. The reaction mixture was stirred at 0° C. for 1 h, then at room temperature overnight before concentrating to give 70 g (100%) of product as an oil.

EXAMPLE 36

This example illustrates the preparation of Compound 84, namely, 3-pyridinecarboxylic acid, 5-(chlorocarbonyl)-2-methoxy-4-(2-methylpropyl)-6-(trifluoromethyl)-methyl ester.

The product of Example 35 (70 g, 0.19 mol) was dissolved in THF (150 mL) and methanol (70 mL) and the solution was allowed to sit without stirring at room temperature. After 28 h, the solution was concentrated and kugelrohr distilled (135°-120° C. at 0.2 kp) to give 51.3 g (74%) of product as a colorless oil. Calcd for C₁₄ H₁₅ Cl₁ F₃ N₁ O₄ ; C, 47.54; H, 4.27; N, 3.96; Cl, 10.02. Found: C, 47.47; H, 4.28; N, 3.92; Cl, 9.99.

EXAMPLE 37

This example illustrates the preparation of 3-pyridinecarboxylic acid, 5-(chlorocarbonyl)-2-methoxy-4-cyclopropylmethyl-6-(trifluoromethyl)-, methyl ester. A mixture of Compound 92 (44.6 g, 129 mmol) and 200 mL of 25% aqueous sodium hydroxide was heated at reflux in 200 mL methanol for 23.5 h. The reaction mixture was cooled to room temperature, diluted with two volumes of ice, and washed with three 300-mL portions of ether. The aqueous layer was acidified with concentrated hydrochloric acid (external ice cooling), and extracted with three 500-mL portions of ether. The combined ether extracts were dried with anhydrous magnesium sulfate, filtered, and solvent removed to give the diacid as a light tan solid. The above diacid (47.0 g of material containing ether by ¹ H NMR) was stirred with 32.1 g phosphorous pentachloride in 400 mL carbon tetrachloride at ambient temperature for 17 h. Solvent was removed at reduced pressure and the residue diluted with 1000 mL hexane and filtered through a column of silica. On removal of solvent, 42.2 g of the diacid chloride was obtained as a yellow oil. This material was stirred at ambient temperature with 50 mL methanol in 100 mL ether for 30 h, after which time volatiles were removed at reduced pressure and the residue was dissolved in 500 mL hexane and filtered through a column of silica. The column was then washed with 3.5 L hexane and the filtrate concentrated to give 35.2 g (78% from Compound 92) of product as a clear oil.

EXAMPLE 38

This example illustrates the preparation of 3,5-pyridinedicarboxylic acid, 2-ethoxy-4-(2-methylpropyl)-6-(trifluoromethyl)-, dimethyl ester.

A mixture of Compound 3 (100 g, 0.26 mol) and 25% NaOH (600 mL) was heated at reflux in 350 mL ethanol overnight, after which time the resulting solution was cooled to room temperature and concentrated. The residue was washed twice with ether to remove impurities and the aqueous layer acidified with concentrated hydrochloric acid. The product was extracted with three portions of ether, dried with anhydrous magnesium sulfate, filtered and solvent removed to give 48.3 g (55%) of the diacid as a dark solid. To this material (48.3 g, 0.14 mol) in 300 mL carbon tetrachloride at 0° C. was added phosphorous pentachloride (66.0 g, 0.32 mol) and the resulting mixture stirred in an ice bath for 1 h, warmed to room temperature and the heated at ca 50° C. for 3.5 h. The reaction mixture was then filtered, concentrated, and the residue kugelrohr distilled at 130° C. at 1.1 kp to give the diacid chloride as a dark oil. Yield was 34 g (65%). To this material (34 g, 0.09 mol) was added methanol (35 mL) and THF (40 mL), and the resulting mixture stirred until homogeneous, then allowed to sit at room temperature overnight. The reaction mixture was concentrated and the residue kugelrohr-distilled at 143° C. at 1.1 kp to give 27 g (81%) of the product as a yellow oil.

The conversion of pyridyl acids to pyridyl amines was used to prepare compounds of the present invention.

EXAMPLE 39

This example illustrates the preparation of Compound 32, namely, 3-pyridinecarboxylic acid, 5-amino-6-methoxy-4-(2-methylpropyl-2-(trifluoromethyl)-, methyl ester. Product of Example 51 (20.10 g, 0.057 mol) in 30 mL acetone was added at room temperature to a vigorously stirring mixture of sodium azide (8.13 g, 0.125 mol) in 45 mL acetone and 15 mL water. An exotherm to 50° C. was observed and the reaction mixture was stirred overnight at room temperature. The reaction mixture was diluted with 100 mL water and extracted with ether (3×100 mL). The combined organic layers were dried over magnesium sulfate, filtered, and concentrated to a solid. Recrystallization from ether/petroleum ether afforded 6.23 g of Compound 32. The mother liquor was chromatographed eluting with 10% ethyl acetate in hexane to give a total product recovery of 15.17 g (86%) Compound 32 as a white solid.

EXAMPLE 40

This example illustrates the preparation of Compound 36, namely, 3-pyridinecarboxylic acid, 5-amino-2-methoxy-4-(2-methylpropyl)-6-(trifluoromethyl)-, methyl ester.

To a stirred slurry of sodium azide (9.62 g, 150 mmol) in 50 mL acetone and 15 mL water was added Compound 84 (23.8 g, 67 mmol). A temperature rise to 35° C. was observed, so external cooling (cold water bath) was applied. The reaction mixture was then stirred at room temperature overnight. The mixture was then diluted with water and extracted with three portions of ether. The combined ether extracts were dried with anhydrous magnesium sulfate, filtered and concentrated to give the crude product, 20.1 g (98%), as a yellow oil. A portion was purified via chromatotron, eluting with 5:1 hexane:ethyl acetate to give an analytical sample.

The conversion of pyridyl acid chlorides to pyridyl aldehydes was used to prepare compounds of the present invention in accordance with the following general scheme. ##STR7##

EXAMPLE 41

This example illustrates the preparation of Compound 40, namely, 3-pyridinecarboxylic acid, 5-hydroxymethyl-2-methoxy-4-(2-methylpropyl)-6-(trifluoromethyl)-, methyl ester.

To a stirred slurry of sodium borohydride (86 g, 2.25 mol) in 2000 mL diglyme was added Compound 84 (419 g, 1.12 mol) in 800 mL diglyme at a rate keeping the temperature ca 10° C. The resulting mixture was allowed to warm to room temperature, whereupon it was stirred for an additional 3 h. The reaction mixture was cooled in an ice bath and to it was slowly added 450 mL concentrated hydrochloric acid, followed by 8 L of water. To this was added 3000 mL methylene chloride with stirring. The aqueous layer was discarded and the organic layer washed with two 10-L portions of 5% sodium chloride solution. The organic layer was concentrated and the residue distilled at 165° C. at 0.05 kp to afford the desired product as a yellow oil. Yield of Compound 40 was 292 g (74%).

EXAMPLE 42

This example illustrates the preparation of Compound 79, namely, 3-pyridinecarboxylic acid, 5-formyl-2-methoxy-4-(2-methylpropyl)-6-(trifluoromethyl)-, methyl ester.

A solution of 3.21 g (10 mmol) of Compound 40 in 25 mL methylene chloride was added slowly at 0° C. to a mixture of Celite (2.37 g), pyridinium chlorochromate (2.37 g, 11 mmol), and 25 mL methylene chloride at 0° C. with vigorous mechanical stirring. The mixture was stirred overnight at room temperature, then filtered and the filter cake rinsed well with methylene chloride. The filtrate was refiltered through a silica gel column, and the resulting solution concentrated by rotary evaporation. The crude product was dissolved in 2% ethyl acetate: 98% cyclohexane and filtered to remove solid impurities. The purified product was obtained by rotary evaporation of the solvent giving 2.41 g (75.4%) of a clear faint green oil. nD: 1.4774.

EXAMPLE 43

This example illustrates the preparation of Compound 117, namely, 3-pyridinecarboxylic acid, 4-(cyclopropylmethyl)-5-(hydroxymethyl)-2-methoxy-6-(trifluoromethyl)-, methyl ester.

To a slurry of sodium borohydride (2.26 g, 60 mmol) in 50 mL THF cooled in an ice bath was added the product of Example 37 (10.55 g, 30 mmol) in 50 mL THF and the resulting mixture stirred overnight, warming to room temperature in the process. The reaction mixture was cooled in an ice bath and quenched by careful addition of 4N hydrochloric acid. The resulting mixture was extracted with three 200 mL portions of ether, dried with anhydrous magnesium sulfate, filtered, and solvent removed to afford the crude product which was found to still contain some unreacted starting material. This material was stirred with an additional 2.26 g sodium borohydride in 100 mL THF at ambient temperature overnight. On workup as above, there was obtained the crude alcohol which was purified by HPLC (8:1 hexane:ethyl acetate) to give 8.1 g (85%) of Compound 117 as an off-white solid, mp 76°-77° C. Calcd for C₁₄ H₁₆ F₃ N₁ O₄ : C, 52.67; H, 5.05; N, 4.39. Found: C, 52.79; H, 5.08; N, 4.36.

EXAMPLE 44

This example illustrates the preparation of Compound 115, namely, 3-pyridinecarboxylic acid, 4-(cyclopropylmethyl)-5-formyl-2-methoxy-6-(trifluoromethyl)-, methyl ester.

To a stirred slurry of pyridinium chlorochromate (5.62 g, 26 mmol) and 5 g Celite in 100 mL methylene chloride was added Compound 17 (7.6 g, 23.8 mmol) in 50 mL methylene chloride and the resulting mixture stirred at ambient temperature for 3 h. The reaction mixture was diluted with 400 mL hexane and filtered through a silica column, which was washed with an additional 500 mL hexane. The eluent was concentrated to give 7.2 g (95%) of Compound 115 as a clear oil, nD: 1.4911. Calcd for C₁₄ H₁₄ F₃ N₁ O₄ : C, 53.00; H, 4.45; N, 4.42. Found: C, 53.05; H, 4.48; N, 4.42.

EXAMPLE 45

This example illustrates another preparation of Compound 2.

The product of Example 9 (330 g, 1.03 mol) from above was mechanically stirred with 195 g K₂ CO₃ in 1500 mL DMF, and to this mixture was added methyl iodide (65 mL, 1034 mmol). The reaction mix was stirred at room temperature for 18 h, then poured into a large excess of water and extracted (3×) with ether. The combined ether layers were washed with 1.2N hydrochloric acid, dried with anhydrous magnesium sulfate, filtered and concentrated to give a crude product which was purified by HPLC (7:1 hexane:ethyl acetate) (or better, by elution with hexane through a silica gel gravity column) to give Compound 2 (70 g, 20%) as a nearly colorless oil. Calcd for C₁₅ H₁₈ F₃ N₁ O₅ : C, 51.58; H, 5.19; N, 4.01. Found: C, 51.44; H, 5.21; N, 3.99.

EXAMPLE 46

This example illustrates the preparation of Compound 80, namely, dimethyl 2-(cyanomethoxy)-4-(2-methylpropyl)-6-(trifluoromethyl)-3,5-pyridine-dicarboxylate. A solution of 6.38 g (0.019 mol) of dimethyl 2-hydroxy-4-(2-methylpropyl)-6-(trifluoromethyl)-3,5-pyridinedicarboxylate (Compound 1) in 50 mL of dimethylformamide was prepared and to it was added 7.2 g (0.06 mol) of bromoacetonitrile and 8.3 g (0.06 mol) of anhydrous potassium carbonate. The mixture was stirred at room temperature overnight then suction filtered. The filtrate was diluted with 400 mL of water and extracted with four 50 mL portions of methylene chloride. The combined extracts were dried with magnesium sulfate and the solvent was removed by rotary evaporation giving 7.09 g (98.9% yield) of a dark amber oil. Silica gel chromatography with 10% ethyl acetate, 90% cyclohexane gave 3.51 g (49%) of Compound 80 as a clear colorless oil. Calcd for C₁₆ H₁₇ N₂ O₅ F₃ : C, 51.34; H, 4.58; N, 7.48. Found: C, 51.26; H, 4.61; N, 7.43.

EXAMPLE 47

This example illustrates the preparation of Compound 22, namely, 3-pyridinecarboxylic acid, 5-cyano-1,6-dihydro-4-(2-methylpropyl)-6-oxo-2-(trifluoromethyl)-, methyl ester.

Product of Example 1 (107 g) was dissolved in thionyl chloride (150 mL). An exotherm to reflux was observed upon the addition of DMF (8 mL). The reaction mixture was heated to reflux for 3 h before cooling and carefully adding to ice water. The product was extracted into ether (3×300 mL), dried over magnesium sulfate, filtered and concentrated to a sticky solid. The crude product was suspended in hot petroleum ether and the solid filtered from the hot solution. Compound 22 was obtained in 82% yield (82 g) as a white solid, MP 159°-163° C. Calcd for C₁₃ H₁₃ F₃ N₂ O₃ : C, 51.66; H, 4.34; N, 9.27. Found: C, 51.60; H, 4.37; N, 8.99.

EXAMPLE 48

This example illustrates the preparation of 3-pyridinecarboxylic acid, 6-chloro-5-cyano-4-(2-methyl propyl)-2-(trifluoromethyl)-, methyl ester. Compound 22 (11.50 g, 38.05 mmol) and phosphorus pentachloride (7.92 g, 38.05 mmol) were heated neat at 140° C. in an oil bath for 2 h. Upon cooling, the reaction mixture was carefully added to ice water and the product extracted into ether (3×100 mL) dried over magnesium sulfate, filtered and concentrated to a dark oil. Purification via HPLC, eluting with hexane:ethyl acetate afforded 4.30 g (35%) of product.

EXAMPLE 49

This example illustrates the preparation of Compound 20, namely, 3-pyridinecarboxylic acid, 5-cyano-6-methoxy-4-(2-methylpropyl)-2-(trifluoromethyl)-, methyl ester. Sodium methoxide (16.17 g, 0.074 mol) was added to the product of Example 48 (24.0 g, 0.074 mol) in methanol (50 mL). The reaction mixture was heated at reflux for 1 h, cooled, diluted with water (150 mL), extracted into ether (3×150 mL), dried over magnesium sulfate, filtered and concentrated to 21.00 g (88%) of an orange oil. Purification via HPLC eluting with 10% ethyl acetate in hexane gave Compound 20 as a colorless oil. n₀ : 1.4723. Calcd for C₁₄ H₁₅ F₃ N₂ O₃ : C, 53.17; H, 4.78; N, 8.86. Found: C, 53.09; H, 4.82; N, 8.80.

Conversion of pyridyl esters to pyridyl acid chlorides attained in accordance with the following general scheme: ##STR8##

EXAMPLE 50

This example illustrates the preparation of 3,5-pyridine dicarboxylic acid, 2-methoxy-4-(2-methylpropyl)-6-(trifluoromethyl)-, 5-methyl ester.

Compound 2 (104.7 g,300 mmol) was heated at reflux in 600 mL of 25% sodium hydroxide and 300 mL methanol for 1 h, then cooled. The residue was diluted with water and washed with ether (3×300 ml), dried over magnesium sulfate, filtered and concentrated to a solid. Yield was 86.2 g (86%).

EXAMPLE 51

This example illustrates the preparation of 5-pyridinecarboxylic acid, 2-methoxy-3-chlorocarbonyl-4-(2-methylpropyl)-6-(trifluoromethyl)-, methyl ester. Product of Example 50 (86.2 g, 257 mmol) was heated at reflux in 170 mL thionyl chloride for 5 h. The reaction mixture was cooled to room temperature, concentrated by rotary evaporator, and eluted through silica gel with hexane. Concentration of the eluent afforded the acid chloride as an oil, sufficiently pure for further derivation. Yield of product was 50.4 g (55.5%).

EXAMPLE 52

This illustrates the preparation of Compound 13, namely, 3,5-pyridinedicarboxylic acid, 4-(carboxymethyl)-2-methoxy-6-(trifluoromethyl)-, dimethyl ester.

To a solution of Compound 86 (20.2 g, 66 mmol) in 100 mL THF at -30° C. was added lithium bis(trimethylsilyl)amide (75 mL of a 1.0M solution in THF, 75 mmol) at a rate maintaining the reaction temperature between -30° C. and -35° C. The reaction mixture was then poured onto 500 cc dry ice and the resulting mixture stirred at ambient temperature until most of the dry ice had dissipated. Water (1 L) was then carefully added to the reaction mixture and the resulting solution was washed with two 300 mL portions of ether. The combined ether extracts were washed with water (300 mL) and the combined aqueous layers cooled in an ice bath and acidified with 4N hydrochloric acid (700 mL). The product was filtered and dried in air to give 20.8 g (91%) of a white solid, mp 167°-168° C.

EXAMPLE 53

This example illustrates the preparation of Compound 87, namely, 3,5-pyridinedicarboxylic acid, 4-(bromomethyl)-2-methoxy-6-(trifluoromethyl)-, dimethyl ester. Compound 13 (98 g, 279 mmol) and red mercuric oxide (50 g, 240 mmol) were stirred in 1:1 carbon tetrachloride: 1,2-dichloroethane (500 mL) and heated to near reflux. A 150-watt floodlight was then turned on and bromine (25 mL) in 200 mL of the above solvent mixture was added over 20 minutes. After the addition was complete, the reaction mixture was refluxed for 1 h under illumination, then stirred at ambient temperature without illumination overnight. The reaction mixture was then poured into aqueous saturated sodium sulfite (500 mL), shaken, the layers separated, and the aqueous layer washed with 300 mL of the mixed solvent. The combined organic layers were dried with anhydrous magnesium sulfate, filtered, and solvent removed to give the crude product which was purified by elution down a silica gel column with 16:1 hexane:ethyl acetate. Yield of product was 70.5 g (66%) of a white solid, mp 65°-66° C.

EXAMPLE 54

This example illustrates the preparation of Compound 88, namely, 3,5-pyridinedicarboxylic acid, 2-methoxy-4-(methoxymethyl)-6-(trifluoromethyl)-, dimethyl ester.

To a solution of Compound 87 (2.2 g, 5.7 mmol) in 20 mL methanol and 20 mL THF was added sodium methoxide (2.65 g of a 25% solution in methanol, 12 mmol) and the resulting solution stirred at ambient temperature for 3 d, after which time it was poured into 100 mL of 1.3N hydrochloric acid and extracted with three 50 mL portions of ether. The combined ether extracts were dried with anhydrous magnesium sulfate, filtered, and solvent removed to give the crude product which was purified by chromatotron, eluting with 8:1 hexane:ethyl acetate. Yield was 1.1 g (57%) of a yellow oil.

EXAMPLE 55

This example illustrates the preparation of Compound 89, namely, 3,5-pyridinedicarboxylic acid, 2-methoxy-4-[(methylthio)methyl]-6-(trifluoromethyl)-, dimethyl ester. A mixture of Compound 87 (2.2 g, 5.7 mmol) and sodium methanethiolate (0.84 g, 12 mmol) in 20 mL THF and 50 mL DMF was stirred at ambient temperature for 10 d, after which time the reaction mixture was poured into 4N hydrochloric acid (100 mL), extracted with three 100 mL portions of ether. The combined ether extracts were washed with three 100 mL portions of 4N hydrochloric acid, dried with anhydrous magnesium sulfate, filtered and solvent removed to give the crude product which was purified by chromatotron, eluting with 8:1 hexane:ethyl acetate. Yield was 1.4 g (70%) of a colorless oil.

EXAMPLE 56

This example illustrates the preparation of Compound 91, namely, 3,5-pyridinedicarboxylic acid, 2-methoxy-4-propyl-6-(trifluoromethyl)-, dimethyl ester.

To a solution of Compound 86, (6.2 g, 20 mmol) in 20 mL THF at -25° C. was added lithium bis(trimethylsilyl)amide (22 mL of a 1.0M solution in THF, 22 mmol) at a rate keeping the temperature below -20° C. The reaction mixture was then stirred at -20° to -30° C. for 30 min, after which time it was added over 15 min to a solution of ethyl iodide (3.43 g, 22 mmol) in 20 mL THF maintained at -25° C. The reaction then was stirred at -25° C. for 30 min, warmed to room temperature over 30 min, and then poured into 100 mL of 4N hydrochloric acid. The resulting mixture was extracted with three 100 mL portions of ether, dried (MgSO₄), filtered and solvent removed to give the crude product which was purified by chromatotron, eluting with 8:1 hexane:ethyl acetate. Purified yield was 2.7 g (40%) of a yellow oil which partially solidified on standing.

EXAMPLE 57

This example illustrates the preparation of Compound 92, namely, 3,5-pyridinedicarboxylic acid, 4-cyclopropylmethyl-2-methoxy-6-(trifluoromethyl)-, dimethyl ester.

To a solution of bromocyclopropane (18.3 g, 150 mmol) in 100 mL THF under nitrogen and previously cooled to -78° C. was added s-butyllithium (100 mL of a 1.5M solution in cyclohexane, 150 mmol) and the resulting mixture stirred at -78° C. for 2 h. This solution was then added over 20 min to a slurry of copper (I) bromide-dimethyl sulfide complex (16.2 g, 79 mmol) in 200 mL THF under nitrogen and previously cooled to -78° C. The resulting mixture was stirred for an additional 30 min, after which time a solution of Compound 87 (10.3 g, 25 mmol) in 100 mL THF was added at a rate keeping the reaction temperature below -60° C. Stirring was continued overnight, during which time the reaction mixture warmed to room temperature. The reaction product was isolated by quenching the reaction mixture with aqueous ammonium chloride at 0° C. followed by extraction with three 500-mL portions of ether. The combined ether extracts were dried with anhydrous magnesium sulfate, filtered, and solvent removed to give the crude product which was purified by chromatotron, eluting with 16:1 hexane:ethyl acetate. Compound 92 (1.2 g, 14%) was obtained as a light yellow oil.

EXAMPLES 58-60

Compound 12, 47 and 65 were prepared by the following general procedure. Sodium methanethiolate (2.5-8 eq) Was added to a solution of the requisite diacid chloride prepared in a manner similar to the product of Example 35 (1 eq) in THF at 0° C. or methylene chloride at room temperature (for Compound 12). The reaction mixture was stirred at room temperature for 2-4 h, or for 5 days (for Compound 12), then added to 1N HCl, extracted with ether (3×), dried (MgSO₄), filtered, and concentrated. Recrystallization in methanol/water for Compound 47, or ether/petroleum ether for Compound 65, or hexane at -78° C. for Compound 12 gave the desired product. Compound 12: white solid (75%) mp: 82°-84° C. Compound 47: white solid (79%) mp: 81°-83° C. Compound 65: white solid (66%) mp: 118°-120° C.

EXAMPLE 61

This illustrates the preparation of Compound 59, namely, 4-cyclobutyl-2-methoxy-3,5-bis(1H-pyrazol-1-ylcarbonyl)-6-(trifluoromethyl)-pyridine. A solution of 4-cyclobutyl-2-methoxy-6-(trifluoromethyl)-3,5-pyridinedicarbonyl chloride (7.00 g, 0,019 mol) and pyrazole (3.85 g, 0,056 mol) in 50 mL THF was stirred at room temperature for 16 h. The reaction mixture was added to 100 mL 1 N HCl and extracted with ether (3×100 mL), dried (MgSO₄), filtered, and concentrated. The crude product was chromatographed, eluting with 10% ethyl acetate in hexane to afford 0.70g (8%) of Compound 59 as a white solid, mp 111°-113° C.

EXAMPLES 62-64

Compounds 41, 46 and 55 were prepared by the following general procedures.

Phosphorous pentachloride (1 eq) was added to a solution of the requisite methyl amide (1 eq) in carbon tetrachloride and heated at 40°-55° C. for 3-16 h. The reaction mixture was cooled and concentrated to an oil. Sodium methanethiolate (1.1-5 eq) was added to a solution of the crude oil in THF and stirred at room temperature for 3 h for Compound 55, 72 h for Compound 41, and 36 h for Compound 46. The reaction mixture was added to 1N HCl and extracted with ether (3×), dried (MgSO₄), filtered, and concentrated. The crude product was chromatographed eluting with 5-10% ethyl acetate in hexane to afford the desired product. Compound 41: pale yellow oil (21%) nD: 1.5020. Compound 46: colorless oil (21%) nD: 1.4967. Compound 55: white solid (39%) mp: 88°-90° C.

EXAMPLES 65-87

Twenty-three additional compounds having the following general structure were prepared by reacting the appropriate monoacid chloride with ZH as defined in Table 1 below except Compounds 104, 107 and 108 which were prepared in accordance with Examples 145-147. The prepared compounds are set out in Table 1 wherein Z is given. ##STR9##

                  TABLE 1                                                          ______________________________________                                         Cmpd        R              Z                                                   ______________________________________                                         105         i-butyl        NH2                                                 102         i-butyl        3-F-Pyrazole                                        101         i-butyl        4-NO.sub.2 -Pyrazole                                108         i-butyl        4-NH.sub.2 -Pyrazole                                104         i-butyl        4-Cl-Pyrazole                                       107         i-butyl        4-AcNH-Pyrazole                                     111         i-butyl        4-CN-Pyrazole                                       97          i-butyl        NH(CH.sub.2).sub.3 Br                               60          i-butyl        triazole                                            51          i-butyl        3-Me-pyrazole                                       44          i-butyl        OC.sub.2 H.sub.5                                    53          i-butyl        SC.sub.2 H.sub.5                                    81          i-butyl        OCH.sub.2 CH.sub.2 F                                82          i-butyl        OCH.sub.2 C.tbd.CH                                  66          i-butyl        1-pyrrolidine                                       67          i-butyl        1-piperidine                                        16          i-butyl        OC.sub.4 H.sub.9                                    68          i-butyl        1-azetidine                                         69          i-butyl        4-morpholino                                        72          i-butyl        2-Me-aziridine                                      52          c-butyl        1-pyrazole                                          119         c-propylmethyl SCH.sub.3                                           116         c-propylmethyl 1-pyrazole                                          71          i-butyl        3-thiazolidine                                      ______________________________________                                    

EXAMPLE 88

This example illustrates the preparation of Compound 45, namely, 3-pyridinecarboxylic acid, 2-ethoxy-4-(2-methylpropyl)-5-[(methylthio)carbonyl]-6-(trifluoromethyl)-, methyl ester. Sodium methanethiolate (1.07 g, 15 mmol) was added to a solution of 3-pyridinecarboxylic acid-2-ethoxy-4(2-methylpropyl)-5-(chlorocarbonyl)-6-(trifluoromethyl)-, methyl ester (5.11 g, 14 mmol) in 30 mL THF at 5° C. The methyl ester (5.11 g, 14 mmol) in 30 mL THF at 5° C. The reaction mixture was stirred at 5° C. for 0.5 h, at room temperature for 60 h, then added to 1N HCl (100 mL) and extracted with ether (3×100 mL), dried (MgSO₄), filtered, and concentrated. The crude product was chromatographed eluting with 1% ethyl acetate in hexane to give 1.48 g (28%) of Compound 45 as a colorless oil, which solidified upon standing at RT. mp: 35°-38° C.

EXAMPLE 89

This example illustrates the preparation of Compound 60, namely, 3-pyridinecarboxylic acid, 2-methoxy-4-(2-methylpropyl)-5-(1H-1,2,4-triazol-1-yl carbonyl)-6-(trifluoromethyl)-, methyl ester.

Triazole, sodium salt (1.42 g, 0.015 mmol) was added to Compound 84 (5.00 g, 0.014 mmol) in 50 mL THF, and the reaction mixture was heated at reflux for 16 h. The reaction mixture was added to 1N HCl (100 mL) and extracted with ether (3×100 mL), dried over MgSO₄, filtered, and concentrated. The crude product was chromatographed eluting with 8% ethyl acetate in hexane to afford 2.85 g (53%) of the desired product as an oil which solidified on standing to a white solid. mp: 64°-66° C. Calcd for C₁₆ H₁₇ N₄ O₄ F₃ : C, 49.74; H, 4.43; N, 14.50. Found: C, 50.03; H, 4.60; N, 14.50.

EXAMPLE 90

This example illustrates the preparation of Compound 66.

Pyrrolidine (3.3 eq) was added to a solution of Compound 84 (1 eq) in ether at 0° C. The reaction mixture was stirred at 0° C. for 0.5 h, then at room temperature for 1 h before acidification with 1N HCl. The product was extracted with ether (3×), dried over MgSO₄, filtered, and concentrated. The crude product was chromatographed, eluting with 5:1 hexane:ethyl acetate, to afford the desired product in 57% yield as a colorless oil, nD: 1.4905. Calcd for C₁₈ H₂₃ N₂ O₄ F₃ : C, 55.66; H, 5.97; N, 7.21. Found: C, 55.76; H, 6.01; N, 7.18.

EXAMPLE 91

This example illustrates the preparation of Compound 42.

A solution of pyrazole (3-5 eq) and Compound 84 in THF was heated at reflux for 16 h. The reaction mixture was added to 1N HCl and extracted with ether (3×), dried over MgSO₄, filtered, and concentrated. The crude product was chromatographed, eluting with 5-10% ethyl acetate in hexane to afford the desired product in 51% yield as a colorless oil, nD: 1.4973. Calcd for C₁₇ H₁₈ N₃ O₄ F₃ : C, 52.99; H, 4.71; N, 10.90. Found: C, 53.10; H, 4.73; N, 10.84.

EXAMPLE 92

This example illustrates the preparation of Compound 51, namely, 3-pyridinecarboxylic acid, 2-methoxy-4-(2-methylpropyl)-5-[(3-methyl-1H-pyrazol-1-yl)carbonyl]-6-(trifluoromethyl)-, methyl ester. 3-Methylpyrazole (3.58 mL, 0.044 mol) was added to a solution of Compound 84 (5.15 g, 0.014 mmol) in 50 mL dichloromethane at 0° C. The reaction mixture was stirred at 0° C. for 0.5 h, then heated at reflux for 16 h. The reaction mixture was then added to 1N HCl (100 mL) and extracted with dichloromethane (3×100 mL), dried over MgSO₄, filtered, and concentrated. The crude product was chromatographed eluting with 10% ethyl acetate in hexane to afford 2.67 g (48%) of product as a yellow oil, nD: 1.4958. Calcd for C₁₈ H₂₀ N₃ O₄ F₃ : C, 54.14; H, 5.05; N, 10.52. Found: C, 54.71; H, 5.21; N, 10.20.

EXAMPLE 93

This example illustrates the preparation of Compound 53, namely, 3-pyridinecarboxylic acid, 5-[(ethylthio)carbonyl]-2-methoxy-4-(2-methylpropyl)-6-(trifluoromethyl)-, methyl ester.

Ethanethiol (1.26 mL, 0.017 mol) was added to a suspension of sodium hydride (0.41 g, 0.017 mol) in 35 mL THF at 0° C. The reaction mixture was stirred at room temperature for 1 h, then Compound 84 (5.49 g, 0.016 mmol) in 15 mL THF was added to the reaction mixture. An exotherm was observed, and an ice bath was used to cool the mixture. After 3 h at room temperature, the reaction mixture was acidified with 1N HCl and extracted with ether (3×100 mL), dried over MgSO₄, filtered, and concentrated. Purification via chromatograph eluting with 1% ethyl acetate in hexane afforded 3.65 g (60%) of product as a white solid, mp: 43°-47 ° C. Calcd for C₁₆ H₂₀ N₁ O₄ S₁ F₃ : C,50.65; H, 5.31; N, 3.69; S, 8.45. Found: C, 50.71; H, 5.34; N, 3.67; S, 8.50.

EXAMPLE 94

This example illustrates the preparation of Compound 16, namely, 3,5-pyridinedicarboxylic acid, 2-methoxy-4-(2-methylpropyl)-6-(trifluoromethyl)-, 5-butyl, 3-methyl diester. Compound 84 (3.54 g, 10 mmol) was heated at reflux in 20 mL n-butanol for 30 h, after which time the reaction mixture was cooled to room temperature, diluted with 300 mL water and extracted with three 200 mL portions of ether. The combined ether extracts were dried over anhydrous MgSO₄, filtered, and solvent was removed to give the crude product which was purified via chromatotron to give the product as a colorless oil. Yield was 2.9 g (74%). Calcd for C₁₈ H₂₄ F₃ N₁ O₅ : C, 55.24; H, 6.18; N, 3.58. Found: C, 55.32; H, 6.19; N, 3.54.

EXAMPLES 95-100

Compounds 97, 100, 101, 102, 105 and 111 were prepared by the following general procedure.

A solution of Compound 84 (10.61 g, 30 mmol) in 100 mL ether was added to a stirred solution of either excess amine or a stoichiometric amount of the requisite amine and excess triethylamine in ether. The resulting mixture stirred at ambient overnight, after which time the reaction mixture was partitioned between ether and water. The ether layer was washed with dilute hydrochloric acid, dried with magnesium chloride, filtered and solvent removed to afford the crude product which was purified as outlined below. Compound 97: recrystallized from 10% ethyl acetate/90% hexane, 55% of a white powder, mp: 133°-134° C. Calcd for C₁₈ H₂₂ BrF₃ N₂ O₄ : C, 44.85; H, 4.87; N, 6.15; Br, 17.55. Found: C, 44.91; H, 4.92; N, 6.13; Br, 17.54. Compound 100: recrystallized from ether, 41% of a white powder, mp: 224°-225° C. Calcd for C₁₆ H₂₀ F₃ N₃ O₅ : C, 49.10; H, 5.15; N, 10.74. Found: C, 49.00; H, 5.19; N,10.71. Compound 101: recrystallized from ether; 82% of white powder, mp: 113°-114° C. Calcd for C₁₇ H₁₇ F₃ N₄ O₆ : C, 47.45; H, 3.98; N, 13.02. Found: C, 47.29; H,4.00; N, 12.97. Compound 102: HPLC (2% ethyl acetate/98% hexane); 48% of colorless oil; nD=1.4925. Calcd for C₁₇ H₁₇ F₄ N₃ O₄ : C, 50.63; H, 4.25; N, 10.42. Found: C, 50.74; H, 4.31; N, 10.37. Compound 105: recrystallized from ether giving 85% yield of white powder, mp: 175°-176° C. Calcd for C₁₄ H₁₇ F₃ N₂ O₄ : C, 50.30; H, 5.13; N, 8.38. Found: C, 50.27; H, 5.16; N, 8.37. Compound 111: HPLC (4% ethyl acetate/96% hexane); 57% of a viscous pale yellow oil, nD=1.5705. Calcd for C₁₈ H₁₇ F₃ N₄ O₄ : C, 52.70; H, 4.18; N, 13.60. Found: C, 53.00; H, 4.43; N, 13.00.

EXAMPLE 101

This example illustrates the preparation of Compound 112, namely, 3,5-pyridinedicarboxylic acid, 2-methoxy-4-(2-methylpropyl)-6-(trifluoromethyl)-, 3-methyl 5-(2,2,2-trifluoroethyl) ester. This material was prepared as in Example 94 to yield 1.8 g (43%) of a colorless oil. nD: 1.5705. Calcd for C₁₆ H₁₇ F₆ N₁ O₅ : C, 46.05; H, 4.11; N, 3.36. Found: C, 46.09; H, 4.14; N, 3.36.

EXAMPLE 102

This example illustrates the preparation of Compound 116, namely, 3-pyridinecarboxylic acid, 4-(cyclopropylmethyl)-2-methoxy-5-(1H-pyrazol-1-ylcarbonyl)-6-(trifluoromethyl)-, methyl ester.

To a solution of the product of Example 37 (2.50 g, 7.1 mmol) in 15 mL THF was added pyrazole (1.93 g, 28.4 mmol) and the resulting mixture stirred at room temperature for 24 h, after which time it was diluted with 50 mL 4N hydrochloric acid and extracted with two 100-mL portions of ether. The combined ether extracts were dried with anhydrous magnesium sulfate, filtered through a column of silica, and the eluent concentrated to give 1.2 g (44%) of product as a white solid. Calcd for C₁₇ H₁₆ F₃ N₃ O₄ : C, 53.27; H, 4.21; N, 10.96. Found: C, 53.24; H, 4.25; N, 10.93.

EXAMPLES 103-104

Compounds 129 and 130 were prepared by the following general procedure.

A mixture of the appropriate dihydro heterocycle (Compound 43 or 54) and 3 eq nickel peroxide was heated at reflux in cyclohexane for 5 days, after which time the reaction mixture was cooled to room temperature and filtered. The filtrate was concentrated to give the crude product, which was separated from unreacted starting material by careful HPLC (5% ethyl acetate/hexane). Compound 129: 21% of white solid, mp 75°-76° C. Calcd for C₁₆ H₁₇ N₂ O₃ S₁ F₃ : C, 51.33; H, 4.58; N, 7.48; S, 8.56. Found: C, 51.50; H, 4.64; N, 7.41; S, 8.49. Compound 130: 12% of white solid, mp 88°-89.5° C. Calcd for C₁₆ H₁₇ N₂ O₄ F₃ : C, 53.63; H, 4.78; N, 7.82. Found: C, 53.77; H, 4.88; N, 7.67.

EXAMPLE 105-106

Compounds 81 and 82 were prepared by the following general procedure.

Compound 84 (3.54 g, 10 mmol) and the requisite alcohol (50 mmol) was stirred overnight at room temperature in 20 mL THF (for Compound 82) or neat (for Compound 81), after which time 10 mmol triethylamine was added and stirring continued overnight. For Compound 81, an additional 5.0 g of the alcohol was added and stirring continued overnight. In each case, on completion of the reaction, the reaction mixture was filtered to remove amine hydrochloride and the filtrate diluted with 100 mL methylene chloride. The organic layer was sequentially washed with dilute hydrochloric acid, water, and aqueous sodium bicarbonate, then dried with anhydrous magnesium sulfate, filtered, and solvent removed to give the crude product, which was purified via chromatotron, eluting with 2% ethyl acetate in cyclohexane. Compound 81: colorless oil (45%) nD: 1.4619. Compound 82: colorless oil (67%) nD: 1.4748.

EXAMPLES 107-114

Compounds 66-73 were prepared by the following general procedure.

The requisite amine (3.3 eq) was added to a solution of Compound 84 (1 eq) in ether at 0° C. The reaction mixture was stirred at 0° C. for 0.5 h, then at room temperature for 1-16 h before acidification with 1N HCl. The product was extracted with ether (3×), dried (MgSO₄), filtered, and concentrated. The crude product was chromatographed, eluting with 5:1 hexane:ethyl acetate, to afford the desired product. Compound 66: colorless oil (57%) nD: 1.4905. Compound 67: colorless oil (48%) nD: 1.4939. Compound 68: white solid (54%) mp: 78°-81° C. Compound 69: white solid (25%) mp: 96°-98° C. Compound 70: white solid (38%) mp: 104°-106° C. Compound 71: colorless oil (55%) nD: 1.5110. Compound 72: colorless oil (45%) nD: 1.4805. Compound 73: white solid (58%) mp: 58°-62° C.

EXAMPLES 115-117

Compounds 42, 49 and 52 were prepared by the following general procedure.

A solution of pyrazole (3-5 eq) and requisite acid chloride (1 eq) in THF was stirred at room temperature for Compound 52 for 16 h, or heated at reflux for Compounds 42 and 49 for 16 h. The reaction mixture was added to 1N HCl and extracted with ether (3×), dried (MgSO₄), filtered, and concentrated. The crude product was chromatographed, eluting with 5-10% ethyl acetate in hexane to afford the desired product. Compound 42: colorless oil (51%) nD: 1.4973. Compound 49: colorless oil (31%) nD: 1.4920. Compound 52: white solid (9%) mp: 86°-88° C.

EXAMPLE 118

This example illustrates the preparation of Compound 103, namely, 3-pyridinecarboxylic acid, 2-methoxy-5-(5-methyl-1,3,4-oxadiazol-2-yl)-4-(2-methylpropyl)-6-(trifluoromethyl)-, methyl ester.

A mixture of Compound 84 (9.2 g, 26 mmol), acethydrazide (3.8 g, 51.3 mmol), and methylene chloride (75 mL) was heated at reflux for six days. The slurry was filtered after cooling and the filtrate was washed with water then dried with MgSO₄. Rotary evaporation gave a crude white solid which was recrystallized from ether to give 4.15 g (41%) of the pyridineacethydrazide. A portion (3.91 g, 10 mmol) of this material was mixed with phosphorus oxychloride (7.3 mL) and phosphorus pentachloride (2.57 g, 12 mmol) and heated at reflux for four hours. The mixture was quenched into ice and extracted with methylene chloride and the organic layer was dried with MgSO4. After rotary evaporation, the residue was purified by silica gel chromatography with 2% ethyl acetate: hexane to give 1.5 g (40%) of Compound 103 as white crystals, mp: 65°-66° C. Anal: Calcd for C₁₆ H₁₈ F₃ N₃ O₄ : C, 51.48; H, 4.86; N, 11.26. Found: C, 51.47; H, 4.84; N, 11.27.

EXAMPLE 119

This example illustrates the preparation of Compound 108, namely, 3-pyridinecarboxylic acid, 5-[(4-amino-1H-pyrazol-1-yl)carbonyl]-2-methoxy-4-(2-methylpropyl)-6-(trifluoromethyl)-, methyl ester.

A solution of 4-nitropyrazole (22.62 g, 200 mmol) in THF (100 mL) was cooled to 0° C., then sodium bis(trimethylsilyl)amide (204.3 mmol) in THF solution was added dropwise. A solution of Compound 84 (70.75 g, 200 mmol) in THF (100 mL) was then added dropwise at 0° C., then the pot was stirred at 25° C. for 30 minutes. The reaction mixture was then poured into 5% hydrochloric acid and extracted with dichloromethane. The organic layer was dried with MgSO₄ and the solvent removed by rotary evaporation. The residue was purified by silica gel chromatography (5% ethyl acetate:hexane) to give 70.14 g (82%) of the pyrazole amide (Compound 101).

A portion of the above pyrazole amide (51.84 g, 120 mmol) was dissolved in 500 mL methanol. After adding 5 g of 5% Pd/C catalyst, the mixture was placed on a Parr shaker overnight at 50 (385 kp) psig hydrogen, 25° C. The material was filtered, solvent evaporated, and the crude product purified by silica gel chromatography (10% ethyl acetate:hexane) to give 34.34 g (71%) of Compound 108 as a glassy solid. A small amount was kugelrohr distilled at 165°-170° C., 0.12 Torr (0.02 kp) to give analytically pure material which was still a glassy solid. Anal: Calcd for C₁₇ H₁₉ F₃ N₄ O₄ : C, 51.00; H, 4.78; N, 13.99. Found: C, 51.05;. H, 4.80; N, 13.90.

EXAMPLE 120

This example illustrates the preparation of Compound 104, namely, 3-pyridinecarboxylic acid, 5-[(4-chloro-1H-pyrazol-1-yl)carbonyl]-2-methoxy-4-(2-methylpropyl)-6-(trifluoromethyl)-, methyl ester.

To a solution of Compound 108 (4.00 g, 10 mmol), anhydrous cupric chloride (1.61 g, 12 mmol) in acetonitrile (20 mL) was added t-butyl nitrite (1.55 g, 15 mmol) at a rate maintaining the temperature below 30° C. After the addition was complete, the resulting solution was heated at 50°-60° C. for one hour. The solvent was removed by rotary evaporation and the residue was mixed with 50 mL water and 15 mL of concentrated hydrochloric acid. Extraction with methylene chloride followed by HPLC (2% ethyl acetate:hexane) gave 0.9 g (21%) of Compound 104 as a yellow oil. Anal: Calcd for C₁₇ H₁₇ F₃ Cl₁ N₃ O₄ : C, 48.64; H, 4.08; N, 10.01; Cl, 8.44. Found: C, 48.71; H, 4.10; N, 9.99; Cl, 8.48.

EXAMPLE 121

This example illustrates the preparation of Compound 107, namely, 3-pyridinecarboxylic acid, 5-[[4-(acetylamino)-1H-pyrazol-1-yl]carbonyl]-2-methoxy-4-(2-methylpropyl)-6-(trifluoromethyl)-, methyl ester.

A mixture of Compound 108 (2.38 g, 5.94 mmol) and acetic anhydride (25 mL) was stirred overnight at room temperature and then the volatiles were removed by rotary evaporation. The residue was recrystallized from hot methylcyclohexane to give 2.13 g (81%) of Compound 107 as fine white crystals, mp: 145°-146° C. Anal: Calcd for C₁₉ H₂₁ F₃ N₄ O₅ : C, 51.58; H, 4.78; N, 12.66. Found: C, 51.57; H, 4.81; N, 12.65.

EXAMPLE 122

Compound 83 was prepared by the following general procedure. To a solution of Compound 1 in DMF (2 mL solvent per mmol of Compound 1) under nitrogen was added 3 eq of the requisite alkyl halide and 6 eq of anhydrous potassium carbonate. The resulting mixture was stirred at room temperature overnight, then diluted with 15-20 volumes of water. This solution was extracted with methylene chloride, the resulting extracts dried with anhydrous magnesium sulfate, filtered and solvent removed to give the crude product which was purified by silica gel column chromatography. Compound 83: colorless oil (54%), bp 95°-101° C. at 0.004 kp.

EXAMPLE 123

This example illustrates the preparation of Compound 43, namely, 3-pyridinecarboxylic acid, 5-(4,5-dihydro-2-oxazolyl)-2-methoxy-4-(2-methylproply)-6-(trifluoromethyl)-, methyl ester.

Compound 38 (5.70 g, 15 mmol) was stirred at room temperature in 25 mL thionyl chloride for 3 h. On removal of volatiles by rotary evaporation, 5.2 g (87%) of the chloroethyl amide was obtained as a white solid. A solution of this material in THF was stirred at room temperature overnight with sodium hydride (0.35 g, 14 mmol), after which time the reaction was heated at reflux overnight, then kept at room temperature for two days. The reaction mixture was then diluted with 1N hydrochloric acid and extracted with ether. The combined ether extracts were dried with anhydrous magnesium sulfate, filtered, and solvent removed to give the crude product which was purified by chromatotron, followed by recrystallization from methanol/water. Yield of product was 2.01 g (42% overall yield) of a white solid, mp 59°-61° C.

EXAMPLES 124-126

Compounds 50, 64 and 75 were prepared by the following general procedure.

A mechanically stirred mixture of the requisite hydroxyamide, e.g., Compound 38 or its methylated and dimethylated analogues, (1 eq) and phosphorous pentasulfide (1 eq) in xylene was heated at 100°-135° C. for 2-5 h. The reaction mixture was added to a saturated solution of sodium bicarbonate, extracted with ether (3×), dried (MgSO₄), filtered, and concentrated. The excess xylene was removed via kugelrohr distillation and the crude product was chromatographed eluting with 5-10% ethyl acetate in hexane to afford the desired product. Compound 50: yellow solid (31%) mp: 59°-62° C. Compound 64: pale orange oil (26%) nD: 1.5085. Compound 75: pink oil (46%) nD: 1.5043.

EXAMPLE 127

This example illustrates the preparation of Compound 74, namely, 3-pyridinecarboxylic acid, 5-(4,5-dihydro-4-methyl-2-thiazolyl)-2-methoxy-4-(2-methylpropyl)-6-(trifluoromethyl)-, methyl ester.

A mixture of lithium sulfide (0.86 g, 0.018 mol) and the product from the reaction of methyl 5-[[(2-hydroxy-2-propyl)amino]carbony]-2-methoxy-4-(2-methypropyl)-6-(trifluoromethyl)-3-pyridinecarboxylate and phosphorus pentachloride (5.04 g, 0.012 mol) in 75 mL THF was stirred at room temperature for 4 days. The reaction mixture was filtered, concentrated, added to water (100 mL) and extracted with ether (3×100 mL), dried (MgSO₄), filtered, and concentrated. The crude product was chromatographed, eluting with 7:1 petroleum ether:ethyl acetate to afford 2.77 g, (60%) of Compound 74 as a pale yellow oil. nD: 1.4999

EXAMPLE 128

This example illustrates the preparation of Compound 54, namely, 3-pyridinecarbothioic acid, 5-(4,5-dihydro-2-thiazolyl)-2-methoxy-4-(2-methylpropyl)-6-(trifluoromethyl)-, S-methyl ester.

A solution of Compound 50 (2.53 g, 6.72 mmol) and 25% sodium hydroxide (50 mL) was heated at reflux for 1 h. The reaction mixture was cooled, diluted with water (50 mL), then washed with ether (2×50 mL). The aqueous phase was acidified with concentrated HCl and extracted with ether (3×50 mL), dried (MgSO₄), filtered, and concentrated to 1.90 g (5.24 mmol, 78%) of the desired carboxylic acid. A mixture of phosphorous pentachloride (1.10 g, 5.24 mmol) and this crude product was heated at 75° C. in 25 mL carbon tetrachloride for 3 h. The reaction mixture was cooled and concentrated to 2.00 g (100%) of the desired acid chloride. A solution of sodium methanethiolate (0.37 g, 5.24 mmol) and the crude acid chloride was stirred in 20 mL THF at room temperature for 72 h. The reaction mixture was added to 1N HCl (100 mL), extracted with ether (3×100 mL), dried (MgSO₄), filtered, and concentrated. The crude product was chromatographed eluting with 10% ethyl acetate in hexane to give 1.25 g (47%) Compound 54 as an oil which solidified to a yellow solid on standing. mp: 58°-64° C.

EXAMPLE 129

This example illustrates the preparation of Compound 98, namely, 3-pyridinecarboxlic acid, 5-(5,6-dihydro-4H-1,3-thiazin-2-yl)-2-methoxy-4-(2-methylpropyl)-6-(trifluoromethyl)-, methyl ester.

A mixture of Compound 84 (12 g, 33.92 mmol), 3-bromopropylamine hydrobromide (8.17 g, 37.32 mmol), triethylamine (7.59 g, 75 mmol), and 75 mL methylene chloride was refluxed for 90 minutes. After cooling, the mixture was washed with 5% hydrochloric acid, saturated NaHCO₃, and brine then dried with MgSO₄. Rotary evaporation gave 8.57 g (55%) of the bromoamide as a white powder which was used for the next step. A portion (4.55 g, 10 mmol) of the bromoamide was mixed with P₂ S₅ (2.4 g, 10.8 mmol) in 30 mL xylene and heated to 120°-130° C., for 30 minutes. After cooling, 100 mL methylene chloride was added and the resulting solution was washed first with water and then with saturated NaHCO₃. The organic layer was dried with MgSO₄ and the solvent removed by rotary evaporation to give 2.75 g (70%) of Compound 98 as an amber oil. Anal: Calcd for C₁₇ H₂₁ F₃ N₂ O₃ S₁ : C, 52.30; H, 5.42; N, 7.18. Found: C, 50.83; H, 5.37; N, 6.80.

EXAMPLE 130

This example illustrates the preparation of Compound 99, namely, 3-pyridinecarboxylic acid, 5-(5,6-dihydro-4H-1,2-oxazin-2-yl)-2-methoxy-4-(2-methylpropyl)-6-(trifluoromethyl)-, methyl ester.

A portion (4.55 g, 10 mmol) of the bromo amide used for Compound 98 was dissolved in 20 mL methylene chloride and benzyltriethylammonium chloride (1.00 g) was added. A 20 mL portion of 50% NaOH was added and the mixture was stirred vigorously for two hours. The layers were separated and the organic layer was washed with brine then dried with MgSO₄ and the solvent rotary evaporated to give 3.61 g (96%) of Compound 99 as a pale yellow oil. n_(D) : 1.4855. Anal: Calcd for C₁₇ H₂₁ F₃ N₂ O₄ : C, 54.54; H, 5.65; N, 7.48. Found: C, 54.56; H, 5.66; N, 7.48.

EXAMPLE 131

This example illustrates the preparation of Compound 106, namely, 3-pyridinecarboxylic acid, 5-cyano-2-methoxy-4-(2-methylpropyl)-6-(trifluoromethyl)-, methyl ester.

A flask was charged with 150 mL THF and saturated with ammonia at 0° C. While maintaining a slow flow of ammonia, a solution of Compound 84 (25 g, 70.7 mmol) in 50 mL THF was added dropwise at 0° C. After stirring for one hour at 0° C., the mixture was filtered and the filtrate rotary evaporated. The residue was dissolved in ether then washed with 5% hydrochloric acid, saturated NaHCO₃, and brine. The ether was dried with MgSO₄ then slowly evaporated under reduced pressure to give 19.74 g (84%) of the amide as a fine white powder, mp: 175°-176° C. A portion of this amide (5.01 g, 15 mmol) was mixed with toluene (50 mL) and chlorocarbonylsulfenyl chloride (10 g, 75 mmol) and heated at 100° C., overnight. The volatiles were removed by rotary evaporation and the residue was purified by HPLC (5% ethyl acetate:hexane) to give 3.46 g (59%) of Compound 106 as a yellow oil. Anal: Calcd for C₁₄ H₁₅ F₃ N₂ O₃ : C, 53.17; H 4.78; N, 8.86. Found: C, 53.36; H, 4.72; N, 8.84.

EXAMPLE 132

This example illustrates the preparation of Compound 90, namely, 3-pyridinecarboxylic acid, 5-(tetrahydro-4-methylene-5-oxo-2-furanyl)-2-methoxy-4-(2-methylpropyl)-6-(trifluoromethyl)-, methyl ester.

A mixture of Compound 79 (7.66 g, 24 mmol), 2-bromomethylacrylic acid (3.96 g, 24 mmol), tin (II) chloride (4.55 g, 24 mmol), 2 mL glacial acetic acid, 4 mL water, and 7.5 mL DME was heated at reflux for 4 h. The reaction mixture was cooled to room temperature, diluted with 100 mL water and made basic with excess solid sodium bicarbonate. The resulting solution was extracted with two 100-mL portions of ether and the ether extracts dried with anhydrous magnesium sulfate, filtered, and solvent removed to afford the crude product which was purified by HPLC (8:1 hexane:ethyl acetate). The yield of Compound 90 was 4.3 g (46%) of a white solid, mp 107°-108° C. Calcd for C₁₈ H₂₀ F₃ N₁ O₅ : C, 55.81; H, 5.20; N, 3.62. Found: C, 55.76; H, 5.21; N, 3.58.

EXAMPLES 133-134

Compounds 93 and 94 were prepared by the following general procedure.

To a solution of Compound 79 (3.2 g, 10 mmol) and either ethanedithiol (1 mL) or propanedithiol (1.2 mL) in 50 mL methylene chloride previously cooled in an ice bath was added titanium tetrachloride (0.4 mL for Compound 93; 0.6 mL for Compound 94) under nitrogen. The resulting mixture was stirred overnight, warming to room temperature in the process. The reaction mixture was then washed with 100 mL water. The layers were separated and the aqueous layer was washed with 100 mL methylene chloride. The combined organic extracts were dried with anhydrous magnesium sulfate and filtered through a short silica gel column. The filtrate was concentrated and purified as described below. Compound 93: HPLC (16:1 hexane:ethyl acetate); 96% pale yellow solid; mp 74°-75° C. Calcd for C₁₆ H₂₀ F₃ N₁ O₃ S₂ : C, 48.60; H, 5.10; N, 3.53; S, 16.22. Found: C, 48.65; H, 3.54; N, 3.53; N, 16.11. Compound 94: HPLC (16:1 hexane:ethyl acetate); 61% colorless solid; mp 98°-100° C. Calcd for C₁₇ H₂₂ F₃ N₁ O₃ S₂ : C, 49.86; H, 5.42; N, 3.42; S, 15.66. Found: C, 49.91; H, 5.45; N, 3.38; S, 15.73.

EXAMPLES 135-136

Compounds 109 and 110 were prepared by the following general procedure.

A mixture of Compound 79 (1 eq) and either bis (trimethylsiloxy)ethane or bis(trimethylsiloxy) propane (2 eq) with a trace (approximately 1 mole %) of trimethylsilyltriflate was stirred at room temperature overnight under nitrogen. Pyridine (1 eq) was added and the pot was diluted with ether. The ether was silica gel filtered then evaporated. The crude product was purified by HPLC. (1-5% ethyl acetate:hexane). Compound 109: white powder (59%) mp: 57°-58° C. Calcd for C₁₆ H₂₀ F₃ N₁ O₅ : C, 52.89; H, 5.55; N, 3.86. Found: C, 52.71; H, 5.63; N, 3.72. Compound 110: white solid (93%) mp: 77°-79° C. Calcd for C₁₇ H₂₂ F₃ N₁ O₅ : C, 54.11; H, 5.88; N, 3.71. Found: C, 54.13; H, 5.89; N, 3.71.

EXAMPLES 137

This example illustrates the preparation of Compound 114, 3-pyridinecarboxylic acid, 2-methoxy-4-(2-methylpropyl)-5-(5-oxazolyl)-6-(trifluoromethyl)-, methyl ester.

Compound 79 (3.19 g, 10 mmol), tosylmethyl isocyanide (1.95 g, 10 mmol), and potassium carbonate (1.38 g, 10 mmol) were heated at reflux in 50 mL methanol for 19 h, after which time the reaction mixture was cooled to room temperature and solvent removed at reduced pressure. The residue was partitioned between ether and water, and the ether layer dried with anhydrous magnesium sulfate, filtered, and solvent removed to afford the crude product. Purification using HPLC (16:1 hexane:ethyl acetate) gave 2.05 g (57%) of Compound 114 as a clear oil, nD: 1.4909. Calcd for C₁₆ H₁₇ F₃ N₂ O₄ : C, 53.63; H, 4.78; N, 7.82. Found: C, 53.79; H, 4.84; N, 7.77.

EXAMPLE 138

This example illustrates the preparation of Compound 118, namely, 3-pyridinecarboxylic acid, 4-cyclopropylmethyl-5-(1,3-dioxolan-2-yl)-2-methoxy-6-(trifluoromethyl)-, methyl ester.

To a mixture of Compound 115 (2.54 g, 8 mmol) and 1,2-bis(trimethylsilyloxy)ethane (3.30 g, 16 mmol) was added 2 drops trimethylsilyl triflate and the resulting solution stirred at room temperature for 25 h, after which time 1 mL pyridine was added. The mixture was diluted with 50 mL hexane and filtered through a column of silica gel. The eluent was concentrated to give a clear oil which was purified by HPLC (18:1 hexane:ethyl acetate) to give 1.63 g (56%) of product as an off-white solid, mp 64°-65° C. Calcd for C₁₆ H₁₈ F₃ N₁ O₅ : C, 53.19; H, 5.02; N, 3.88. Found: C, 53.36; H, 5.04; N, 3.85.

EXAMPLE 139

This example illustrates the preparation of Compound 122, namely, 3-pyridinecarboxylic acid, 2-methoxy-4-(2-methylpropyl)-5-(1,3-oxathiolan-2-yl)-6-(trifluoromethyl)-, methyl ester.

A mixture of Compound 79 (15.96 g, 50 mmol), 2-mercaptoethanol (4.69 g, 60 mmol), and methylene chloride (125 mL) was cooled to -78° C., and then TiCl4 (2.16 g, 11.4 mmol) was added dropwise by syringe. After 30 minutes, the cooling was removed and the pot was stirred at 25° C., overnight. The reaction mixture was quenched into iced water, extracted with ether, and then the ether was removed by rotary evaporation. The residue was filtered through silica gel with 2% ethyl acetate:hexane and the solvent evaporated. The product was then recrystallized from hot hexane to give 10.84 g (57%) of Compound 122 as a fine white powder, mp: 79°-81° C. Calcd for C₁₆ H₂₀ N₁ O₄ S₁ : C, 50.65; H, 5.31; N, 3.69; S, 8.45. Found: C, 50.70; H, 5.33; N, 3.67; S, 8.45.

EXAMPLE 140

This example illustrates the preparation of Compound 123, namely, 3-pyridinecarboxylic acid, 2-methoxy-4-(2-methylpropyl)-5-(4-oxo-1,3-dioxolan-2-yl)-6-(trifluoromethyl)-, methyl ester.

Trimethylsilyl(trimethylsilyloxy) acetate (6.61 g, 30 mmol) was mixed with Compound 79 (4.79 g, 15 mmol) and then three drops of trimethylsilyl triflate were added. The mixture was stirred overnight at room temperature overnight. Ether (250 mL) and pyridine (2 mL) were added and the mixture was filtered. After evaporating the ether, the residue was purified by silica gel chromatography with 5% ethyl acetate:hexane to give 3.50 g (62%) of Compound 123 as a white solid, mp: 94°-96° C. Calcd for C₁₆ H₁₈ F₃ N_(1O) ₆ : C, 50.93; H, 4.81; N, 3.71. Found: C, 50.97; H, 4.83; N, 3.70.

EXAMPLES 141-142

Compounds 126 and 127 were prepared by the following general procedure.

A solution of metachloroperbenzoic acid (4.16 g, 20 mmol) in 25 mL methylene chloride was added slowly to a mixture of Compound 122 (7.59 g, 20 mmol) in 25 mL methylene chloride and stirred for two hours at 25° C. The mixture was then washed with 10% sodium sulfite followed by saturated NaHCO₃ and brine. The organic layer was dried with MgSO₄ and the solvent evaporated. The residue was purified by silica gel chromatography (10% ethyl acetate:hexane) to give 7.64 g (97%) of Compound 126 as a white solid, mp: 67°-69° C. A portion (3.98 g, 10 mmol) of this material was dissolved in 25 mL methylene chloride and a solution of m-chloroperbenzoic acid (2.5 g, 12 mmol) in 25 mL methylene chloride was added and the mixture stirred overnight. A precipitate was filtered off and the filtrate was worked up as before. Silica gel chromatography of the crude material gave 1.61 g (39%) of Compound 127 as a white solid, mp: 117°-120° C. Compound 126: Calcd for C₁₆ H₂₀ F₃ N₁ O₅ S₁ : C, 48.60; H, 5.10; N, 3.54; S, 8.11. Found: C, 48.57; H, 5.10; N, 3.51; S, 8.09. Compound 127: Calcd for C₁₆ H₂₀ F₃ N₁ O₆ S₁ : C, 46.71; H, 4.90; N, 3.40; S, 7.79. Found: C, 46.69; H, 4.91; N, 3.39; S, 7.73.

EXAMPLES 143-144

Compounds 14 and 15 were prepared by the following general procedure.

The requisite aminopyridine Compound 36 or Compound 32 (10 mmol), 2,5-dimethoxytetrahydrofuran (1.45 g, 11 mmol) were heated at 90° C. in 20 mL glacial acetic acid for 1.5-2 h, after which time the reaction mixture was cooled to room temperature and poured into excess aqueous sodium carbonate. The resulting mixture was extracted with three 100-mL portions of ether, dried with anhydrous magnesium sulfate, filtered and solvent removed to give the crude product which was purified by column chromatography or chromatotron, eluting with 10:1 hexane:ethyl acetate. Compound 14: yellow oil (84%) Compound 15: white solid (81%), mp 36°-37° C.

EXAMPLES 145-147

Compounds 56, 76 and 61 were prepared by the following general procedure.

A solution of the requisite amine (Compound 32 or Compound 36) (1 eq), trimethyl orthoformate (3 eq), and p-toluenesulfonic acid (0.1 eq) were heated at 90°-106° C. for 3-16 h. The reaction mixture was then cooled, concentrated, and filtered through silica gel. The crude product was chromatographed eluting with 8-10% ethyl acetate:petroleum ether to afford the desired product. Compound 56: colorless oil (57%) nD: 1.4815. Compound 76: pale yellow oil (49%) nD: 1.4755. Compound 61: colorless oil (63%) nD: 1.4742.

EXAMPLES 148-149

Compounds 57 and 62 were prepared by the following general procedure.

A mixture of the requisite amine, Compound 32 or Compound 36, (1 eq), dimethylformamide dimethyl acetal (6 eq), and p-toluenesulfonic acid (0.1 eq) was heated at reflux overnight. Upon cooling, the reaction mixture was concentrated, suspended in ether, filtered, and concentrated. The crude product was filtered through silica gel, and subsequent recrystallization in methanol/water for Compound 37, or purification via chromatography, eluting with 8:1 petroleum ether:ethyl acetate for Compound 62 afforded the desired product. Compound 57: white solid (62%) mp: 52°-55° C. Compound 62: colorless oil (80%) nD: 1.4926.

EXAMPLES 150-152

Compounds 58, 77 and 78 were prepared by the following general procedure.

Formic acid (30 eq) was added to acetic anhydride (26 eq) at 0° C. The resulting mixture was allowed to gradually warm to room temperature after which the mixture was heated at 50°-65° C. for 10-15 minutes. The reaction mixture was then cooled to 0° C., and the requisite aminopyridine (Compound 32 or Compound 36) (1 eq) was added thereto. After stirring at room temperature for 16 h, the reaction mixture was concentrated. The residue was dissolved in ether, filtered, and concentrated. Purification via chromatography eluting with 3:1 ethyl acetate:hexane afforded the desired product as a solid.

Lawesson's reagent (0.5 eq) was added to a solution of the above product in HMPA, and the reaction mixture was heated at 100° C. for 3 h. Upon cooling, the reaction mixture was added to water and extracted with ether (3×). The organic phase was washed with water (1×), dried (MgSO₄), filtered and concentrated.

A solution of the requisite thioamide, (1 eq), methyl iodide (1 eq), and potassium carbonate (1.5 eq) in DMF was heated at 55°-60° C. for 3-4 h. Upon cooling, the reaction mixture was diluted with water and extracted with ether (3×), dried (MgSO₄), filtered and concentrated. The crude product was chromatographed eluting with 8-10% ethyl acetate in hexane to afford the desired product as an oil. Compound 58: light yellow oil (44%) nD: 1.5169. Compound 77: colorless oil (75%) nD: 1.5077. Compound 78: colorless oil (61%) nD: 1.5066.

The following is a listing by number and nomenclature of compounds herein.

    ______________________________________                                         Compound                                                                       No.      Name                                                                  ______________________________________                                         1        3,5-pyridinedicarboxylic acid, 2-hydroxy-4-(2-                                 methylpropyl)-6-(trifluoromethyl)-, dimethyl                                   ester                                                                 2        3,5-pyridinedicarboxylic acid, 2-methoxy-4-(2-                                 methylpropyl)-6-(trifluoromethyl)-, dimethyl                                   ester                                                                 3        3,5-pyridinedicarboxylic acid, 2-ethoxy-4-(2-                                  methylpropyl)-6-(trifluoromethyl)-, 3-ethyl 5-                                 methyl ester, hydrate (1:0.4)                                         4        3,5-pyridinedicarboxylic acid, 2-methoxy-4-(2-                                 methylpropyl)-6-(trifluoromethyl)-, 3-ethyl 5-                                 methyl ester                                                          5        3,5-pyridinedicarboxylic acid, 2-(1-                                           methylethoxy)-4-(2-methylpropyl)-6-                                            (trifluoromethyl)-, 3-ethyl 5-methyl ester                            6        3,5-pyridinedicarboxylic acid, 2-ethoxy-4-(2-                                  methylpropyl)-6-(trifluoromethyl)-, dimethyl                                   ester                                                                 7        3,5-pyridinedicarboxylic acid, 4-(2-                                           methylpropyl)-2-propyloxy-6-                                                   (trifluoromethyl)-, 3-ethyl 5-methyl ester                            8        3-pyridinecarboxylic acid, 6-ethoxy-4-(2-                                      methylpropyl)-5-[(methylthio)carbonyl]-2-                                      (trifluoromethyl)-, methyl ester                                      9        3,5-pyridinedicarboxylic acid, 4-cyclopropyl-                                  2-methoxy-6-(trifluoromethyl)-, dimethyl ester                        10       3-pyridinecarboxylic acid, 5-(aminocarbonyl)-                                  1,2,3,4-tetrahydro-4-(2-methylpropyl)-6-                                       (pentafluoroethyl)-, ethyl ester                                      11       3,5-pyridinedicarboxylic acid, 2-methoxy-4-(2-                                 methylpropyl)-6-(pentafluoroethyl)-, 5-ethyl 3-                                methyl ester                                                          12       3,5-pyridinedicarbothioic acid, 4-cyclopropyl-                                 2-methoxy-6-(trifluoromethyl)-, S,S-dimethyl                                   ester                                                                 13       3,5-pyridinedicarboxylic acid, 4-                                              (carboxymethyl)-2-methoxy-6-                                                   (trifluoromethyl)-, dimethyl ester                                    14       3-pyridinecarboxylic acid, 6-methoxy-4-(2-                                     methylpropyl)-5-(1H-pyrrol-1-yl)-2-                                            (trifluoromethyl)-, methyl ester                                      15       3-pyridinecarboxylic acid, 2-methoxy-4-(2-                                     methylpropyl)-5-(1H-pyrrol-1-yl)-6-                                            (trifluoromethyl)-, methyl ester                                      16       3,5-pyridinedicarboxylic acid, 2-methoxy-4-(2-                                 methylpropyl)-6-(trifluoromethyl)-, 5 butyl 3-                                 methyl ester                                                          17       3-pyridinecarboxylic acid, 5-                                                  [(dimethylamino)carbony]-6-ethoxy-4-(2-                                        methylpropyl)-2-(trifluoromethyl)-, methyl                                     ester                                                                 18       3,5-pyridinedicarboxylic acid, 2-ethoxy-4-(2-                                  methylpropyl)-6-(trifluoromethyl)-, 5-methyl                                   ester                                                                 19       3,5-pyridinedicarbothioic acid, 2-ethoxy-4-(2-                                 methylpropyl)-6-(trifluoromethyl)-, S,S-                                       dimethyl ester                                                        20       3-pyridinecarboxylic acid, 5-cyano-6-methoxy-                                  4-(2-methylpropyl)-2-(trifluoromethyl)-, methyl                                ester                                                                 21       3-pyridinecarboxylic acid, 6-methoxy-5-                                        [(methylamino)carbonyl]-4-(2-methylpropyl)-2-                                  (trifluoromethyl)-, methyl ester                                      22       3-pyridinecarboxylic acid, 5-cyano-1,6-dihydro-                                4-(2-methylpropyl)-6-oxo-2-(trifluoromethyl)-,                                 methyl ester                                                          23       3,5-pyridinecarboxylic acid, 4-(2-methyl-                                      propyl)-2-(2-propenyloxy)-6-                                                   (trifluoromethyl)-, 3-ethyl 5-methyl ester,                                    hydrate (1:0.3)                                                       24       3-pyridinecarboxylic acid, 6-methoxy-4-(2-                                     methylpropyl)-5-(1H-pyrazol-1-ylcarbonyl)-2-                                   (trifluoromethyl)-, methyl ester, hydrate                                      (1:0.3)                                                               25       3-pyridinecarboxylic acid, 5-[[(2-                                             hydroxyethyl)amino]carbonyl]-6-methoxy-4-(2-                                   methylpropyl)-2-(trifluoromethyl)-, methyl                                     ester, hydrate (1:0.2)                                                26       3,5-pyridinedicarboxylic acid, 2-                                              (difluoromethyl)-6-methoxy-4-(2-methylpropyl)-,                                5-ethyl 3-methyl ester                                                27       3-pyridinecarboxylic acid, 5-(4,5-dihydro-2-                                   oxazolyl)-6-methoxy-4-(2-methylpropyl)-2-                                      (trifluoromethyl)-, methyl ester                                      28       3-pyridinecarboxylic acid, 6-methoxy-4-(2-                                     methylpropyl)-5-(1H-imidazol-1-ylcarbonyl)-2-                                  (trifluoromethyl)-, methyl ester                                      29       3,5-pyridinedicarboxylic acid, 2-                                              (chlorodifluoromethyl)-6-methoxy-4-(2-                                         methylpropyl)-, 5-ethyl 3-methyl ester                                30       3,5-pyridinedicarboxylic acid, 2-                                              (chlorodifluoromethyl)-6-methoxy-4-(2-                                         methylpropyl)-, dimethyl ester                                        31       3,5-pyridinedicarboxylic acid, 2-                                              (difluoromethyl)-6-methoxy-4-(2-                                               methylpropyl)-, dimethyl ester                                        32       3-pyridinecarboxylic acid, 5-amino-6-methoxy-                                  4-(2-methylpropyl)-2-(trifluoromethyl)-, methyl                                ester                                                                 33       3-pyridinecarboxylic acid, 6-methoxy-4-(2-                                     methylpropyl)-5-[(methylthio)carbonyl]-2-                                      (trifluoromethyl)-, methyl ester                                      34       3-pyridinecarboxylic acid, 2-methoxy-4-(2-                                     methylpropyl)-5-[(methylthio)carbonyl]-6-                                      (trifluoromethyl)-, methyl ester                                      35       3-pyridinecarboxylic acid, 5-(aminocarbonyl)-                                  1,4,5,6-tetrahydro-4-(2-methylpropyl)-6-oxo-2-                                 (trifluoromethyl)-, ethyl ester                                       36       3-pyridinecarboxylic acid, 5-amino-2-methoxy-                                  4-(2-methylpropyl)-6-(trifluoromethyl)-, methyl                                ester                                                                 37       3-pyridinecarboxylic acid, 2-methoxy-5-                                        [(methylamino)carbonyl]-4-(2-methylpropyl)-6-                                  (trifluoromethyl)-, methyl ester                                      38       3-pyridinecarboxylic acid, 5-[[(2-                                             hydroxyethyl)amino]carbonyl]-2-methoxy-4-(2-                                   methylpropyl)-6-(trifluoromethyl)-, methyl                                     ester                                                                 39       3,5-pyridinedicarboxylic acid, 2-ethoxy-4-(2-                                  methylpropyl)-6-(trifluoromethyl)-, diethyl                                    ester                                                                 40       3-pyridinecarboxylic acid, 5-(hydroxymethyl)-                                  2-methoxy-4-(2-methylpropyl)-6-                                                (trifluoromethyl)-, methyl ester                                      41       3-pyridinecarboxylic acid, 2-methoxy-5-                                        [(methylimino)(methylthio)methyl]-4-(2-                                        methylpropyl)-6-(trifluoromethyl)-, methyl                                     ester                                                                 42       3-pyridinecarboxylic acid, 2-methoxy-4-(2-                                     methylpropyl)-5-(1H-pyrazol-1-ylcarbonyl)-6-                                   (trifluoromethyl)-, methyl ester                                      43       3-pyridinecarboxylic acid, 5-(4,5-dihydro-2-                                   oxazolyl)-2-methoxy-4-(2-methylpropyl)-6-                                      (trifluoromethyl)-, methyl ester                                      44       3,5-pyridinedicarboxylic acid, 2-methoxy-4-(2-                                 methylpropyl)-6-(trifluoromethyl)-, 5-ethyl 3-                                 methyl ester                                                          45       3-pyridinecarboxylic acid, 2-ethoxy-4-(2-                                      methylpropyl)-5-[(methylthio)carbonyl]-6-                                      (trifluoromethyl)-, methyl ester                                      46       3-pyridinecarboxylic acid, 2-ethoxy-5-                                         [(methylimino)(methylthio)methyl]-4-(2-                                        methylpropyl)-6-(trifluoromethyl)-, methyl                                     ester                                                                 47       3,5-pyridinedicarbothioic acid, 2-methoxy-4-                                   (2-methylpropyl)-6-(trifluoromethyl)-, S,S,-                                   dimethyl ester                                                        48       3,5-pyridinedicarboxylic acid, 4-cyclobutyl-2-                                 methoxy-6-(trifluoromethyl)-, dimethyl ester                          49       3-pyridinecarboxylic acid, 2-ethoxy-4-(2-                                      methylpropyl)-5-(1H-pyrazol-1-ylcarbonyl)-6-                                   (trifluoromethyl)-, methyl ester                                      50       3-pyridinecarboxylic acid, 5-(4,5-dihydro-2-                                   thiazolyl)-2-methoxy-4-(2-methylpropyl)-6-                                     (trifluoromethyl)-, methyl ester                                      51       3-pyridinecarboxylic acid, 2-methoxy-4-(2-                                     methylpropyl)-5-[(3-methyl-1H-pyrazol-1-                                       yl)carbonyl]-6-(trifluoromethyl)-, methyl ester                       52       3-pyridinecarboxylic acid, 4-cyclobutyl-2-                                     methoxy-5-(1H-pyrazol-1-ylcarbonyl)-6-                                         (trifluoromethyl)-, methyl ester                                      53       3-pyridinecarboxylic acid, 5-                                                  [(ethylthio)carbonyl]-2-methoxy-4-(2-                                          methylpropyl)-6-(trifluoromethyl)-,                                            methyl ester                                                          54       3-pyridinecarbothioic acid, 5-(4,5-dihydro-2-                                  thiazolyl)-2-methoxy-4-(2-methylpropyl)-6-                                     (trifluoromethyl)-, S-methyl ester                                    55       3-pyridinecarboxylic acid, 6-methoxy-5-                                        [(methylimino)(methylthio) methyl]-4-(2-                                       methylpropyl)-2-(trifluoromethyl)-,                                            methyl ester                                                          56       3-pyridinecarboxylic acid, 6-methoxy-5-                                        [(methoxymethylene)amino]-4-(2-methylproyl)-                                   2-(trifluoromethyl)-, methyl ester                                    57       3-pyridinecarboxylic acid,                                                     5[[(dimethylamino)methylene]amino]-6-methoxy-                                  4-(2-methylpropyl)-2-(trifluoromethyl)-,                                       methyl ester                                                          58       3-pyridinecarboxylic acid, 6-methoxy-4-(2-                                     methylpropyl)-5-[(methylthiomethylene)]amino-                                  2-(trifluoromethyl)-, methyl ester                                    59       4-cyclobutyl-2-methoxy-3,5-bis(1H-pyrazol-1-                                   ylcarbonyl)-6-(trifluoromethyl)-pyridine                              60       3-pyridinecarboxylic acid, 2-methoxy-4-(2-                                     methylpropyl)-5-(1H-1,2,4-triazol-1-                                           ylcarbonyl)-6-(trifluoromethyl)-, methyl ester                        61       3-pyridinecarboxylic acid, 5-                                                  [(ethoxymethylene)amino]-2-methoxy-4-(2-                                       methylpropyl)-6-(trifluoromethyl)-,                                            methyl ester                                                          62       3-pyridinecarboxylic acid, 5-                                                  [[(dimethylamino)methylene]amino]-2-methoxy-4-                                 (2-methylpropyl)-6-(trifluoromethyl)-,                                         methyl ester                                                          63       3,5-pyridinedicarboxylic acid, 2-methoxy-4-(1-                                 methylethyl)-6-(trifluoromethyl)-,                                             dimethyl ester                                                        64       3-pyridinecarboxylic acid, 5-(4,5-dihydro-5-                                   methyl-2-thiazolyl)-2-methoxy-4-(2-                                            methylpropyl)-6-(trifluoromethyl)-,                                            methyl ester                                                          65       3,5 pyridinedicarbothioic acid, 4-cyclobutyl-                                  2-methoxy-6-(trifluoromethyl)-, S,S-dimethyl                                   ester                                                                 66       3-pyridinecarboxylic acid, 2-methoxy-4-(2-                                     methylpropyl)-5-(1-pyrrolidinylcarbonyl)-6-                                    (trifluoromethyl)-, methyl ester                                      67       3-pyridinecarboxylic acid, 2-methoxy-4-(2-                                     methylpropyl)-5-(1-piperidinylcarbonyl)-6-                                     (trifluoromethyl)-, methyl ester                                      68       3-pyridinecarboxylic acid, 5-(1-                                               azetidinylcarbonyl)-2-methoxy-4-(2-                                            methylpropyl)-6-(trifluoromethyl)-,                                            methyl ester                                                          69       3-pyridinecarboxylic acid, 2-methoxy-4-(2-                                     methylpropyl)-5-(4-morpholinyl)carbonyl-6-                                     (trifluoromethyl)-, methyl ester                                      70       3-pyridinecarboxylic acid, 2-methoxy-4-(2-                                     methylpropyl)-5-(4-thiomorpholinylcarbonyl)-6-                                 (trifluoromethyl)-, methyl ester                                      71       3-pyridinecarboxylic acid, 2-                                                  methoxy-4-(2-methylpropyl)-5-(3-                                               thiazolidinylcarbonyl)-6-                                                      (trifluoromethyl)-, methyl ester                                      72       3-pyridinecarboxylic acid, 1-methoxy-5-[(2-                                    methyl-1-aziridinyl) carbonyl]-4-(2-                                           methylpropyl)-6-(trifluoromethyl)-,                                            methyl ester                                                          73       3-pyridinecarboxylic acid, 5-[(hexahydro-1H-                                   azepin-1-yl) carbonyl]-2-methoxy-4-(2-                                         methylpropyl)-6-(trifluoromethyl)-,                                            methyl ester                                                          74       3-pyridinecarboxylic acid, 5-(4,5-dihydro-4-                                   methyl-2-thiazolyl)-2-methoxy-4-(2-                                            methylpropyl)-6-(trifluoromethyl)-,                                            methyl ester                                                          75       3-pyridinecarboxylic acid, 5-(4,5-dihydro-4,4-                                 dimethyl-2-thiazolyl)-2-methoxy-4-(2-                                          methylpropyl)-6-(trifluoromethyl)-,                                            methyl ester                                                          76       3-pyridinecarboxylic acid, 2-methoxy-5-                                        [(methoxymethylene)amino]-4-(2-methylpropyl)-                                  6-(trifluoromethyl)-, methyl ester                                    77       3-pyridinecarboxylic acid, 2-methoxy-4-(2-                                     methylpropyl)-5-[[(methylthio)methylene]amino]-                                6-(trifluoromethyl)-, methyl ester                                    78       3-pyridinecarboxylic acid, 5-                                                  [[(ethylthio)methylene]amino]-2-methoxy-4-(2-                                  methylpropyl)-6-(trifluoromethyl)-,                                            methyl ester                                                          79       3-pyridinecarboxylic acid, 5-formyl-2-methoxy-                                 4-(2-methylpropyl)-6-(trifluoromethyl)-,                                       methyl ester                                                          80       3,5-pyridinedicarboxylic acid, 2-                                              (cyanomethoxy)-4-(2-methylpropyl)-6-                                           (trifluoromethyl)-, dimethyl ester                                    81       3,5-pyridinedicarboxylic acid, 2-methoxy-4-(2-                                 methylpropyl)-6-(trifluoromethyl)-, 5-(2-                                      fluoroethyl) 3-methyl ester                                           82       3,5-pyridinedicarboxylic acid, 2-methoxy-4-(2-                                 methylpropyl)-6-(trifluoromethyl)-, 3-methyl 5-                                (2-propynyl)ester                                                     83       3,5-pyridinedicarboxylic acid, 4-(2-                                           methylpropyl)-2-(2-propynyloxy)-6-                                             (trifluoromethyl)-, dimethyl ester                                    84       3-pyridinecarboxylic acid, 5-(chlorocarbonyl)-                                 2-methoxy-4-(2-methylpropyl)-6-                                                (trifluoromethyl)-, methyl ester                                      85       3-pyridinecarboxylic acid, 2-(cyanomethyl)-4-                                  (2-methylpropyl)-5-(1H-pyrazol-1-ylcarbonyl)-                                  6-(trifluoromethyl)-, methyl ester                                    86       3,5-pyridinedicarboxylic acid, 2-methoxy-4-                                    methyl-6-(trifluoromethyl)-, dimethyl ester                           87       3,5-pyridinedicarboxylic acid, 4-(bromomethyl)-                                2-methoxy-6-(trifluoromethyl)-, dimethyl ester                        88       3,5-pyridinedicarboxylic acid, 2-methoxy-4-                                    (methoxymethyl)-6-(trifluoromethyl)-,                                          dimethyl ester                                                        89       3,5-pyridinedicarboxylic acid, 2-methoxy-4-                                    [(methylthio)methyl]-6-(trifluoromethyl)-,                                     dimethyl ester                                                        90       3-pyridinecarboxylic acid, 5-(tetrahydro-4-                                    methylene-5-oxo-2-furanyl)-2-methoxy-4-(2-                                     methylpropyl)-6-(trifluoromethyl)-,                                            methyl ester                                                          91       3,5-pyridinedicarboxylic acid, 2-methoxy-4-                                    propyl-6-(trifluoromethyl)-, dimethyl ester                           92       3,5-pyridinedicarboxylic acid, 4-                                              (cyclopropylmethyl)-2-methoxy-6-                                               (trifluoromethyl)-, dimethyl ester                                    93       3-pyridinecarboxylic acid, 5-(1,3-dithiolan-2-                                 yl)-2-methoxy-4-(2-methylpropyl)-6-                                            (trifluoromethyl)-, methyl ester                                      94       3-pyridinecarboxylic acid, 5-(1,3-dithian-2-                                   yl)-2-methoxy-4-(2-methylpropyl)-6-                                            (trifluoromethyl)-, methyl ester                                      95       3-pyridinecarboxylic acid, 5-[(chloro[2-                                       chloroethyl)imino]methyl]-2-methoxy-4-(2-                                      methylpropyl)-6-(trifluoromethyl)-,                                            methyl ester                                                          96       3,5-pyridinedicarboxylic acid, 4-(2-                                           methylpropyl)-2-(trichloromethoxy)-6-                                          (trifluoromethyl)-, dimethyl ester                                    97       3-pyridinecarboxylic acid, 5-[[(3-                                             bromopropyl)amino]carbonyl]-2-methoxy-4-(2-                                    methylpropyl)-6-(trifluoromethyl)-,                                            methyl ester                                                          98       3-pyridinecarboxylic acid, 5-(5,6-dihydro-4H-                                  1,3-thiazin-2-yl)-2-methoxy-4-(2-                                              methylpropyl)-6-(trifluoromethyl)-,                                            methyl ester                                                          99       3-pyridinecarboxylic acid, 5-(5,6-dihydro-4H-                                  1,2-oxazin-2-yl)-2-methoxy-4-(2-methylpropyl)-                                 6-(trifluoromethyl)-, methyl ester                                    100      3,5-pyridinedicarboxylic acid, 2-methoxy-4-(2-                                 methylpropyl)-6-(trifluoromethyl)-, 3-methyl                                   ester 5-(2-acetylhydrazide)                                           101      3-pyridinecarboxylic acid, 2-methoxy-4-(2-                                     methylpropyl)-5-[(4-nitro-1H-pyrazol-1-                                        yl)carbonyl]-6-(trifluoromethyl)-, methyl ester                       102      3-pyridinecarboxylic acid, 5-[(3-fluoro-1H-                                    pyrazol-1-yl)carbonyl]-2-methoxy-4-(2-                                         methylpropyl)-6-(trifluoromethyl)-,                                            methyl ester                                                          103      3-pyridinecarboxylic acid, 2-methoxy-5-(5-                                     methyl-1,3,4-oxadiazol-2-yl)-4-(2-                                             methylpropyl)-6-(trifluoromethyl)-,                                            methyl ester                                                          104      3-pyridinecarboxylic acid, 5-[(4-chloro-1H-                                    pyrazol-1-yl)]carbonyl]-2-methoxy-4-(2-                                        methylpropyl)-6-(trifluoromethyl)-,                                            methyl ester                                                          105      3-pyridinecarboxylic acid, 5-(aminocarbonyl)-                                  2-methoxy-4-(2-methylpropyl)-6-                                                (trifluoromethyl)-, methyl ester                                      106      3-pyridinecarboxylic acid, 5-cyano-2-methoxy-                                  4-(2-methylpropyl)-6-(trifluoromethyl)-,                                       methyl ester                                                          107      3-pyridinecarboxylic acid, 5-[[4-(acetylamino)-                                1H-pyrazol-1-yl]carbonyl]-2-methoxy-4-(2-                                      methylpropyl)-6-(trifluoromethyl)-,                                            methyl ester                                                          108      3-pyridinecarboxylic acid, 5-[(4-amino-1H-                                     pyrazol-1-yl)carbonyl]-2-methoxy-4-(2-                                         methylpropyl)-6-(trifluoromethyl)-,                                            methyl ester                                                          109      3-pyridinecarboxylic acid, 5-(1,3-dioxolan-2-                                  yl)-2-methoxy-4-(2-methylpropyl)-6-                                            (trifluoromethyl)-, methyl ester                                      110      3-pyridinecarboxylic acid, 5-(1,3-dioxan-2-                                    yl)-2-methoxy-4-(2-methylpropyl)-6-                                            (trifluoromethyl)-, methyl ester                                      111      3-pyridinecarboxylic acid, 5-[(4-cyano-1H-                                     pyrazol-1-yl)carbonyl]-2-methoxy-4-(2-                                         methylpropyl)-6-(trifluoromethyl)-,                                            methyl ester                                                          112      3,5-pyridinedicarboxylic acid, 2-methoxy-4-(2-                                 methylpropyl)-6-(trifluoromethyl)-, 3-methyl 5-                                (2,2,2-trifluoroethyl) ester                                          113      3-pyridinecarboxylic acid, 5-(chlorocarbonyl)-                                 4-(cyclopropylmethyl)-2-methoxy-6-                                             (trifluoromethyl)-, methyl ester                                      114      3-pyridinecarboxylic acid, 2-methoxy-4-(2-                                     methylpropyl)-5-(5-oxazolyl)-6-                                                (trifluoromethyl)-, methyl ester                                      115      3-pyridinecarboxylic acid, 4-                                                  (cyclopropylmethyl)-5-formyl-2-methoxy-6-                                      (trifluoromethyl)-, methyl ester                                      116      3-pyridinecarboxylic acid, 4-                                                  (cyclopropylmethyl)-2-methoxy-5-(1H-pyrazol-1-                                 ylcarbonyl)-6-(trifluoromethyl)-, methyl ester                        117      3-pyridinecarboxylic acid, 4-                                                  (cyclopropylmethyl)-5-(hydroxymethyl)-2-                                       methoxy-6-(trifluoromethyl)-, methyl ester                            118      3-pyridinecarboxylic acid, 4-                                                  (cyclopropylmethyl)-5-(1,3-dioxolan-2-yl)-2-                                   methoxy-6-(trifluoromethyl)-, methyl ester                            119      3-pyridinecarboxylic acid, 4-                                                  (cyclopropylmethyl)-2-methoxy-5-                                               [(methylthio)carbonyl]-6-(trifluoromethyl)-,                                   methyl ester                                                          120      3-pyridinecarboxylic acid, 5-[(4-bromo-1-                                      oxobutyl)amino]-2-methoxy-4-(2-methylpropyl)-                                  6-(trifluoromethyl)-, methyl ester                                    121      3-pyridinecarboxylic acid, 5-[(dihydro-2(3H)-                                  furanylidene)amino]-2-methoxy-4-(2-                                            methylpropyl)-6-(trifluoromethyl)-,                                            methyl ester                                                          122      3-pyridinecarboxylic acid, 2-methoxy-4-(2-                                     methylpropyl)-5-(1,3-oxathiolan-2-yl)-6-                                       (trifluoromethyl)-, methyl ester                                      123      3-pyridinecarboxylic acid, 2-methoxy-4-(2-                                     methylpropyl)-5-(4-oxo-1,3-dioxolan-2-yl)-6-                                   (trifluoromethyl)-, methyl ester                                      124      3,5-pyridinedicarboxylic acid, 2-methoxy-4-(2-                                 methylpropyl)-6-(trifluoromethyl)-, 3-methyl                                   ester, 5-(ethoxymethylene)hydrazide                                   125      3-pyridinecarboxylic acid, 2-methoxy-4-(2-                                     methylpropyl)-5-(1,3,4-oxadiazol-2-yl)-6-                                      (trifluoromethyl)-, methyl ester                                      126      3-pyridinecarboxylic acid, 2-methoxy-4-(2-                                     methylpropyl)-5-(1,3-oxathiolan-2-yl)-6-                                       (trifluoromethyl)-, methyl ester, S-oxide                             127      3-pyridinecarboxylic acid, 2-methoxy-4-(2-                                     methylpropyl)-5-(3,3-dioxo-1,3-oxathiolan-2-                                   yl)-6-(trifluoromethyl)-, methyl ester                                128      3-pyridinecarboxylic acid, 5-[[2-                                              hydroxyethyl)imino]methyl]-2-methoxy-4-(2-                                     methylpropyl)-6-(trifluoromethyl)-,                                            methyl ester                                                          129      3-pyridinecarboxylic acid, 2-methoxy-4-(2-                                     methylpropyl)-5-(2-thiazolyl)-6-                                               (trifluoromethyl)-, methyl ester                                      130      3-pyridinecarboxylic acid, 2-methoxy-4-(2-                                     methylpropyl)-5-(2-oxazolyl)-6-                                                (trifluoromethyl)-, methyl ester                                      131      3-pyridinecarbothioic acid, 2-methoxy-4-(2-                                    methylpropyl)-5-(1H-pyrazol-1-ylcarbonyl)-6-                                   (trifluoromethyl)-, S-methyl ester                                    132      3-pyridinecarboxylic acid, 5-(2-                                               isoxazolidinecarbonyl)-2-methoxy-4-(2-                                         methylpropyl)-6-(trifluoromethyl)-,                                            methyl ester                                                          133      3-pyridinecarbothioic acid, 5-(chlorocarbonyl)-                                2-methoxy-4-(2-methylpropyl)-6-                                                (trifluoromethyl)-, S-methyl ester                                    134      3-pyridinecarbothioic acid, 5-(hydroxymethyl)-                                 2-methoxy-4-(2-methylpropyl)-6-                                                (trifluoromethyl)-, S-methyl ester                                    135      3-pyridinecarbothioic acid, 5-formyl-2-                                        methoxy-4-(2-methylpropyl)-6-                                                  (trifluoromethyl)-, S-methyl ester                                    136      3-pyridinecarbothioic acid, 5-(1,3-dioxan-2-                                   yl)-2-methoxy-4-(2-methylpropyl)-6-                                            (trifluoromethyl)-, S-methyl ester                                    137      3-pyridinecarboxylic acid, 4-cyclobutyl-2-                                     methoxy-5-[(methylthio)carbonyl]-6-                                            (trifluoromethyl)-, methyl ester                                      138      3-pyridinecarboxylic acid, 5-(chlorocarbonyl)-                                 4-cyclobutyl-2-methoxy-6-(trifluoromethyl)-,                                   methyl ester                                                          139      3-pyridinecarboxylic acid, 4-cyclobutyl-5-                                     formyl-2-methoxy-6-(trifluoromethyl)-,                                         methyl ester                                                          140      3-pyridinecarboxylic acid, 4-cyclobutyl-5-[(3-                                 fluoro-1H-pyrazol-1-yl)carbonyl]-2-methoxy-6-                                  (trifluoromethyl)-, methyl ester                                      141      3-pyridinecarboxylic acid, 4-cyclobutyl-2-                                     methoxy-5-(1H-1,2,4-triazol-1-ylcarbonyl-6-                                    (trifluoromethyl)-, methyl ester                                      ______________________________________                                    

PRE-EMERGENT ACTIVITY ON PLANTS

As noted above, compounds of this invention have been found to be effective as herbicides, particularly pre-emergent herbicides. Tables A and B summarize results of tests conducted to determine the pre-emergent herbicidal activity of the compounds of this invention. The herbicidal ratings used in Tables A and B were assigned according to a scale based on the percent inhibition of each plant species. The herbicide rating symbols in Tables A and S are defined as follows:

    ______________________________________                                         % Inhibition      Rating                                                       ______________________________________                                          0-24             0                                                            25-49             1                                                            50-74             2                                                            75-100            3                                                            Not planted       -- or a blank                                                Species planted, no data                                                                         N                                                            ______________________________________                                    

One set of pre-emergent tests was conducted as follows:

Topsoil was placed in a pan and compacted to a depth of 0.95 to 1.27 cm. from the top of the pan. A predetermined number of seeds of each of several monocotyledonous and dicotyledonous annual plant species and/or vegetative propagules of various perennial plant species were placed on top of the soil. The soil required to level fill a pan after seeding or adding vegetative propagules was weighed into another pan. A known amount of the test compound dissolved or suspended in an organic solvent or water and applied in acetone or water as a carrier was thoroughly mixed with this cover soil, and the herbicide/soil mixture was used as a cover layer for the previously prepared pan. In Table A below the amounts of active ingredient were all equivalent to an application rate of 11.2 kilograms/hectare (kg/ha). After treatment, the pans were moved to a greenhouse bench where they were watered as needed to give adequate moisture for germination and growth.

Approximately 10-14 days (usually 11 days) after planting and treating, the plants were observed and the results recorded.

The plant species usually regarded as weeds which were utilized in one set of pre-emergent activity tests, the data for which are shown in Table A, are identified by letter headings printed vertically above the columns according to the following legend:

CATH--Canada thistle*

RHQG--Quackgrass*

COBU--Cocklebur*

RHJG--Rhizome Johnsongrass*

VELE--Velvetleaf

DOBR--Downy Brome

MOGL--Morningglory

BYGR--Barnyardgrass

COLQ--Common Lambsquarters

ANBG--Annual Bluegrass

PESW--Pennsylvania Smartweed

SEJG--Seedling Johnsongrass

YENS--Yellow Nutsedge*

INMU--Indian Mustard

WIBW--Wild Buckwheat

                                      TABLE A                                      __________________________________________________________________________            Y A S D B M C V I W C C P R R                                                  e n e o y o o e n i a o e h h                                           Compound                                                                              n b j b g g b l m b t l s q j                                           No.    s g g r r l u e u w h q w g g                                           __________________________________________________________________________     1      0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           2      3 --                                                                               --                                                                               3 3 3 3 3 --                                                                               --                                                                               3 3 3 3 3                                           3      1 --                                                                               --                                                                               3 3 2 0 0 --                                                                               --                                                                               3 3 2 3 0                                           4      1 --                                                                               --                                                                               3 3 3 0 3 --                                                                               --                                                                               3 3 3 3 3                                           5      0 --                                                                               --                                                                               3 3 0 0 0 --                                                                               --                                                                               0 3 1 2 3                                           6      1 --                                                                               --                                                                               --                                                                               3 3 1 3 --                                                                               --                                                                               3 3 3 3 3                                           7      0 --                                                                               --                                                                               --                                                                               3 0 0 0 --                                                                               --                                                                               0 3 1 0 0                                           8      0 --                                                                               --                                                                               --                                                                               3 3 0 3 --                                                                               --                                                                               0 3 3 3 0                                           9      3 --                                                                               --                                                                               3 3 3 0 3 --                                                                               --                                                                               3 3 3 3 3                                           10     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           11     3 --                                                                               --                                                                               3 3 2 0 1 --                                                                               --                                                                               1 3 3 3 0                                           12     1 --                                                                               --                                                                               3 3 3 1 3 --                                                                               --                                                                               1 3 3 3 0                                           13     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 N 0 0                                           14     0 --                                                                               --                                                                               3 3 3 0 3 --                                                                               --                                                                               3 3 3 2 3                                           15     1 --                                                                               --                                                                               3 3 3 0 3 --                                                                               --                                                                               3 3 3 3 3                                           16     0 --                                                                               --                                                                               3 3 3 0 3 --                                                                               --                                                                               2 3 3 3 0                                           17     0 --                                                                               --                                                                               --                                                                               3 0 0 0 --                                                                               --                                                                               0 2 0 0 0                                           18     0 --                                                                               --                                                                               --                                                                               0 0 1 0 --                                                                               --                                                                               0 2 0 0 0                                           19     0 --                                                                               --                                                                               --                                                                               3 2 1 3 --                                                                               --                                                                               1 3 3 3 0                                           20     0 --                                                                               --                                                                               3 3 2 0 0 --                                                                               --                                                                               0 3 1 3 3                                           21     0 --                                                                               --                                                                               3 3 0 0 0 --                                                                               --                                                                               0 3 0 3 0                                           22     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           23     0 --                                                                               --                                                                               3 3 1 0 1 --                                                                               --                                                                               0 3 3 1 3                                           24     0 --                                                                               --                                                                               3 3 3 0 3 --                                                                               --                                                                               1 3 3 3 3                                           25     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           26     0 --                                                                               --                                                                               3 3 3 0 3 --                                                                               --                                                                               3 3 3 3 3                                           27     2 --                                                                               --                                                                               3 3 3 1 3 --                                                                               --                                                                               3 3 3 3 0                                           28     0 --                                                                               --                                                                               3 3 2 3 1 --                                                                               --                                                                               0 3 2 0 0                                           29     1 --                                                                               --                                                                               3 3 3 0 3 --                                                                               --                                                                               0 3 3 3 1                                           30     2 --                                                                               --                                                                               3 3 3 1 3 --                                                                               --                                                                               3 3 3 3 3                                           31     2 --                                                                               --                                                                               3 3 3 0 3 --                                                                               --                                                                               0 3 3 3 3                                           32     0 --                                                                               --                                                                               0 3 0 0 0 --                                                                               --                                                                               0 3 2 0 N                                           33     2 --                                                                               --                                                                               3 3 3 1 3 --                                                                               --                                                                               2 3 3 3 3                                           34     3 --                                                                               --                                                                               3 3 3 3 2 --                                                                               --                                                                               3 3 3 3 3                                           35     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           36     0 --                                                                               --                                                                               3 3 2 0 2 --                                                                               --                                                                               1 3 3 3 3                                           37     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 3 0 0 0                                           38     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           39     0 --                                                                               --                                                                               3 3 1 0 2 --                                                                               --                                                                               0 3 3 0 0                                           40     0 --                                                                               --                                                                               3 3 0 0 1 --                                                                               --                                                                               0 3 3 3 0                                           41     0 --                                                                               --                                                                               3 3 3 1 3 --                                                                               --                                                                               3 3 3 3 0                                           42     2 --                                                                               --                                                                               3 3 3 3 3 --                                                                               --                                                                               3 3 3 3 2                                           43     3 --                                                                               --                                                                               3 3 3 2 3 --                                                                               --                                                                               3 3 3 3 3                                           44     3 --                                                                               --                                                                               3 3 3 1 3 --                                                                               --                                                                               3 3 3 3 3                                           45     3 --                                                                               --                                                                               3 3 3 0 3 --                                                                               --                                                                               3 3 3 3 3                                           46     0 --                                                                               --                                                                               3 3 3 0 2 --                                                                               --                                                                               3 3 3 3 0                                           47     3 --                                                                               --                                                                               3 3 3 1 3 --                                                                               --                                                                               3 3 3 3 3                                           48     3 --                                                                               --                                                                               3 3 3 3 3 --                                                                               --                                                                               3 3 3 3 3                                           49     3 --                                                                               --                                                                               3 3 3 1 3 --                                                                               --                                                                               3 3 3 3 2                                           50     3 --                                                                               --                                                                               3 3 3 3 3 --                                                                               --                                                                               3 3 3 3 3                                           51     1 --                                                                               --                                                                               3 3 3 1 3 --                                                                               --                                                                               3 3 3 3 3                                           52     3 --                                                                               --                                                                               3 3 3 3 3 --                                                                               --                                                                               3 3 3 3 0                                           53     0 --                                                                               --                                                                               3 3 3 3 3 --                                                                               --                                                                               0 3 3 3 0                                           54     0 --                                                                               --                                                                               3 3 3 1 3 --                                                                               --                                                                               3 3 3 3 0                                           55     0 --                                                                               --                                                                               3 3 1 0 1 --                                                                               --                                                                               0 3 3 3 0                                           56     0 --                                                                               --                                                                               3 3 0 0 0 --                                                                               --                                                                               0 3 0 0 0                                           57     0 --                                                                               --                                                                               3 3 2 0 2 --                                                                               --                                                                               0 3 0 3 3                                           58     0 --                                                                               --                                                                               3 3 1 0 1 --                                                                               --                                                                               0 3 3 3 0                                           59     0 --                                                                               --                                                                               3 3 3 0 2 --                                                                               --                                                                               0 3 3 3 0                                           60     0 --                                                                               --                                                                               3 3 3 1 3 --                                                                               --                                                                               3 3 3 3 3                                           61     0 --                                                                               --                                                                               3 3 3 1 3 --                                                                               --                                                                               2 3 3 3 3                                           62     1 --                                                                               --                                                                               3 3 3 1 3 --                                                                               --                                                                               3 3 3 3 2                                           63     3 --                                                                               --                                                                               3 3 3 0 3 --                                                                               --                                                                               2 3 3 3 3                                           64     0 --                                                                               --                                                                               3 3 3 3 3 --                                                                               --                                                                               3 3 3 2 0                                           65     1 --                                                                               --                                                                               3 3 3 1 3 --                                                                               --                                                                               3 3 3 2 0                                           66     0 --                                                                               --                                                                               3 3 2 0 1 --                                                                               --                                                                               3 3 1 3 0                                           67     0 --                                                                               --                                                                               3 3 3 0 2 --                                                                               --                                                                               3 3 3 3 0                                           68     0 --                                                                               --                                                                               3 3 2 0 0 --                                                                               --                                                                               1 3 1 3 1                                           69     0 --                                                                               --                                                                               1 3 1 0 0 --                                                                               --                                                                               2 3 0 3 2                                           70     1 --                                                                               --                                                                               2 3 2 0 0 --                                                                               --                                                                               2 3 0 2 0                                           71     0 --                                                                               --                                                                               3 3 2 0 1 --                                                                               --                                                                               1 3 2 2 0                                           72     0 --                                                                               --                                                                               3 3 1 0 1 --                                                                               --                                                                               0 3 1 0 0                                           73     0 --                                                                               --                                                                               3 3 2 0 1 --                                                                               --                                                                               3 3 3 3 3                                           74     1 --                                                                               --                                                                               3 3 3 3 3 --                                                                               --                                                                               3 3 3 3 3                                           75     3 --                                                                               --                                                                               3 3 3 2 3 --                                                                               --                                                                               3 3 3 3 1                                           76     2 --                                                                               --                                                                               3 3 3 0 3 --                                                                               --                                                                               3 3 3 3 2                                           77     3 --                                                                               --                                                                               3 3 3 2 3 --                                                                               --                                                                               3 3 3 3 3                                           78     0 --                                                                               --                                                                               3 3 3 0 3 --                                                                               --                                                                               3 3 3 2 0                                           79     0 --                                                                               --                                                                               3 3 2 0 2 --                                                                               --                                                                               3 3 3 3 --                                          80     2 --                                                                               --                                                                               3 3 3 1 3 --                                                                               --                                                                               3 3 3 1 --                                          81     3 --                                                                               --                                                                               3 3 3 3 3 --                                                                               --                                                                               3 3 3 3 --                                          82     1 --                                                                               --                                                                               3 3 3 2 3 --                                                                               --                                                                               3 3 3 2 --                                          83     0 --                                                                               --                                                                               3 3 3 0 3 --                                                                               --                                                                               1 3 3 3 1                                           84     0 --                                                                               --                                                                               3 3 1 0 0 --                                                                               --                                                                               3 3 N 0 0                                           85     0 3 3 3 3 3 0 3 3 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          86     0 --                                                                               --                                                                               3 3 3 0 2 --                                                                               --                                                                               0 3 2 3 3                                           87     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 2 N 0 0                                           88     0 --                                                                               --                                                                               1 3 1 0 1 --                                                                               --                                                                               0 2 N 0 0                                           89     0 --                                                                               --                                                                               1 3 3 1 3 --                                                                               --                                                                               3 3 3 1 0                                           90     0 3 1 2 2 0 0 0 0 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                          91     3 --                                                                               --                                                                               3 3 3 1 3 --                                                                               --                                                                               3 3 3 3 3                                           92     3 --                                                                               --                                                                               3 3 3 2 3 --                                                                               --                                                                               3 3 3 3 0                                           93     0 3 3 3 3 3 0 3 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          94     0 3 3 2 3 3 1 3 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          95     0 3 3 1 3 0 0 2 2 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          96     0 3 3 2 3 3 0 3 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          97     0 3 3 2 3 2 0 2 3 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          98     0 3 3 3 3 3 0 3 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          99     0 3 3 3 3 2 0 3 3 1 --                                                                               --                                                                               --                                                                               --                                                                               --                                          100    0 3 0 0 0 0 0 0 0 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                          101    0 3 3 2 3 2 1 2 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          102    3 3 3 3 3 3 3 3 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          103    0 3 3 2 3 3 0 3 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          104    0 3 3 2 3 2 0 2 3 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          105    0 3 3 0 3 0 0 0 0 1 --                                                                               --                                                                               --                                                                               --                                                                               --                                          106    0 3 0 3 3 2 0 0 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          107    0 3 3 0 3 3 0 3 3 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          108    0 3 2 0 3 0 0 2 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          109    3 3 3 3 3 3 3 3 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          110    2 3 3 3 3 3 3 3 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          111    0 3 3 2 3 3 0 3 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          112    0 3 3 3 3 2 0 3 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          113    0 3 3 3 3 1 0 1 0 1 --                                                                               --                                                                               --                                                                               --                                                                               --                                          114    1 3 3 3 3 2 0 3 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          115    1 3 3 3 3 2 0 2 3 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          116    3 3 3 3 3 3 2 3 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          117    0 3 3 0 3 0 0 1 2 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          118    3 3 3 3 3 3 0 3 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          119    3 3 3 3 3 3 2 3 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          120    2 3 3 3 3 3 3 3 N N --                                                                               --                                                                               --                                                                               --                                                                               --                                          121    2 3 3 3 3 2 3 3 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          122    2 3 3 3 3 3 0 3 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          123    0 3 3 3 3 1 0 1 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          124    0 0 0 0 0 0 0 0 0 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                          125    0 3 3 3 3 3 0 3 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          126    0 3 3 3 3 3 1 3 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          127    0 3 3 3 3 1 0 1 2 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          128    0 3 3 3 3 2 0 1 3 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          129    3 3 3 3 3 3 2 3 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          130    3 3 3 3 3 3 1 3 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          131    3 3 3 3 3 3 2 3 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          132    0 3 3 3 3 2 0 3 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          133    0 0 0 0 0 0 0 0 1 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                          134    0 3 0 0 3 0 0 2 1 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                          135    0 3 2 3 3 0 0 2 3 1 --                                                                               --                                                                               --                                                                               --                                                                               --                                          136    1 3 3 3 3 2 2 2 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          137    3 3 3 3 3 3 3 3 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          138    0 0 0 0 0 0 0 0 0 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                          139    0 3 3 3 3 2 0 3 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          140    0 3 3 3 3 3 0 3 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          141    2 3 3 3 3 3 0 3 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                          __________________________________________________________________________

In another set of tests, the pre-emergence activity of compounds of this invention was tested on weeds in the presence of crop plants. In these tests the following procedure was used:

Topsoil was sieved to pass through a 1.27 cm screen. Fertilizer was added to the topsoil in some of the tests, while in testing other compounds the fertilizer was omitted. The mixture was then sterilized by exposure to methyl bromide or by heating.

The topsoil mixture was placed in individual aluminum pans and compacted to a depth of about 1.27 cm. from the top of the pan. A predetermined number of seeds of each of several monocotyledonous and dicotyledonous plant species and, where noted, vegetative propagules of various perennial plant species were slanted in the pans. The soil required to level fill a pan after seeding or adding vegetative propagules was weighed into another pan. A known amount of the test compound was dissolved or suspended in acetone or a suitable organic solvent as a 1% solution or suspension and applied to the cover soil using a sprayer at the desired rate. The spray was thoroughly mixed with this cover soil, and the herbicide/soil mixture was used as a cover layer for the previously prepared pan. Untreated soil was used as a cover layer for control pans. In Table B below the amount of active ingredient applied is shown. After treatment, the pans were moved to a greenhouse bench. Moisture was supplied to each pan as needed for germination and growth. Growth of each species was observed and corrective measures (greenhouse fumigation, insecticide treatment, and the like) were applied as needed. Approximately 10-14 days (usually 11 days) after planting and treating, the plants were observed and the results recorded.

The pre-emergence data for weeds in the presence of crop plants are shown in the following Table B. In these tests, the plants are identified according to the following column headings.

    ______________________________________                                         SOBE -- Soybean   VELE -- Velvetleaf                                           SUBE -- Sugarbeet DOBR -- Downy Brome                                          WHEZ -- Wheat     PRMI -- Proso Millet                                         RICE -- Rice      BYGR -- Barnyardgrass                                        GRSO -- Grain Sorghum                                                                            LACG -- Large Crabgrass                                      COBU -- Cocklebur GRFT -- Green Foxtail                                        WIBW -- Wild Buckwheat                                                                           CORN -- Corn                                                 MOGL -- Morningglory                                                                             COTZ -- Cotton                                               HESE -- Hemp Sesbania                                                                            RAPE -- Oilseed Rape                                         COLQ -- Common    JIWE -- Jimsonweed                                           Lambsquarters     COCW -- Common                                               PESW -- Pennsylvania                                                                             Chickweed                                                    Smartweed         RUTH -- Russian Thistle                                      ANBG -- Annual Bluegrass                                                                         SEJG -- Seedling                                             BARZ -- Barley    Johnsongrass                                                 WIOA -- Wild Oats                                                              ______________________________________                                    

                                      TABLE B                                      __________________________________________________________________________             S C R C W M H J V W R G C D P B L G S C P C A B R S W                  Com-    o o a o i o e i e h i r o o r y a       r                                                                              u                                                                              o                                                                              e o n a u    e                                                                         i                      pound                                                                              Rate                                                                               b t p b b g s w l e c s r b m g c       f                                                                              b                                                                              l                                                                              s c b r t    j                                                                         o                      No. kg/ha                                                                              e z e u w l e e e z e o n r i r g       t                                                                              e                                                                              q                                                                              w w g z h    g                                                                         a                      __________________________________________________________________________     2   5.6050                                                                             3 --                                                                               --                                                                               2 3 3 3 --                                                                               3 3 3 3 --                                                                               3 3 3 3 --                                                                               3 3 3 --                                                                               --                                                                               --                                                                               --                                                                               --                                                                               --                     5.6050                                                                             3 2 3 0 3 3 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             2 0 2 N 3 2 1 2 2 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 --                                                                               --                                                                               1 3 3 2 --                                                                               2 3 3 3 --                                                                               3 3 3 3       --                                                                             3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             1 --                                                                               --                                                                               0 2 2 2 --                                                                               1 3 2 3 --                                                                               3 3 3 3       --                                                                             3                                                                              1                                                                              3 --                        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--                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 0 0 0 1 1 1 1 1 3 3 3 1 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                               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                                                          --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               1 0 0 --                                                                               0 2 0 0 --                                                                               1 2 3 3 --      2                                                                              0                                                                              2                                                                              --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 0 0 0 1 0 0 0 0 1 1 3 1 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 1 0 0 --                                                                               0 1 3 2       --                                                                             1                                                                              0                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               1 1 0 0 --                                                                               0 0 1 1       --                                                                             1                                                                              1                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 0 0 0 0 0 0 0 0 0 2 0 1 1 2 0 2       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 1 0 0 --                                                                               0 0 0 2       --                                                                             1                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     3   5.6050                                                                             0 --                                                                               --                                                                               0 3 3 2 --                                                                               1 3 3 3 1 3 3 3 3       3                                                                              1                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 1 0 0 0 1 3 3 3       3                                                                              0                                                                              0                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       1                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     4   5.6050                                                                             2 --                                                                               --                                                                               0 3 3 3 --                                                                               3 3 3 3 3 --                                                                               3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 1 0 1 --                                                                               1 3 2 3 1 --                                                                               3 3 3       3                                                                              2                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               1 3 2 3 1 --                                                                               3 3 3       3                                                                              1                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 1 1 1 0 --                                                                               3 1 3       3                                                                              0                                                                              0                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 1 0 --                                                                               2 2 1       3                                                                              0                                                                              0                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 --                                                                               0 0 0       1                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 --                                                                               0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 --                                                                               0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     5   5.6050                                                                             0 --                                                                               --                                                                               0 3 0 0 --                                                                               1 2 0 2 0 2 2 3 3       3                                                                              0                                                                              3                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 2 0 0 --                                                                               0 0 0 0 0 0 0 0 2       1                                                                              0                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 1 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     6   5.6050                                                                             0 --                                                                               --                                                                               0 3 1 2 --                                                                               1 3 2 3 2 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 3 0 0 0 3 3 3 3       3                                                                              2                                                                              2                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 1 2 2 3       3                                                                              1                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 3       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 1       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 1       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 2       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 1       0                                                                              0                                                                              N                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     7   5.6050                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 1 1 1 3       3                                                                              1                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 2       2                                                                              1                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 2       1                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 1       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     8   5.6050                                                                             1 --                                                                               --                                                                               0 3 2 3 --                                                                               3 3 3 3 2 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 0 0 1 --                                                                               0 2 2 2 0 3 3 3 3       3                                                                              0                                                                              1                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 1 0 2 0 2 3 3 3       3                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 1 0 0 2 2 2       2                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 2       1                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     9   5.6050                                                                             3 --                                                                               --                                                                               0 3 2 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         5.6050                                                                             3 --                                                                               --                                                                               1 2 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             2 --                                                                               --                                                                               1 3 2 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             1 --                                                                               --                                                                               0 1 2 2 --                                                                               3 2 3 3 2 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             N --                                                                               --                                                                               2 1 1 0 --                                                                               0 0 3 3 0 3 3 3 3       3                                                                              0                                                                              2                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             1 --                                                                               --                                                                               1 3 2 2 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              2                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 1 1 0 --                                                                               0 1 3 3 0 1 0 3 3       3                                                                              0                                                                              1                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             1 --                                                                               --                                                                               0 0 1 0 --                                                                               2 1 3 3 2 3 3 3 3       3                                                                              1                                                                              3                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 N 0 0 --                                                                               1 0 3 3 0 2 3 3 3       3                                                                              0                                                                              3                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             N --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 3 0 0 1 2 2 3       3                                                                              N                                                                              0                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 2 3 0 3 1 3 3       3                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             N --                                                                               --                                                                               1 0 0 0 --                                                                               0 0 1 0 0 0 0 1 3       3                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 02                                                                               0 N 0 0 0 1 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 2 1       3                                                                              0                                                                              N                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 2 0 0 1       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 1 1       2                                                                              0                                                                              N                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 1 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     11  5.6050                                                                             0 --                                                                               --                                                                               1 3 0 1 --                                                                               0 3 2 1 1 3 3 3 3       3                                                                              1                                                                              3                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 3 0 0 --                                                                               0 1 1 0 0 3 3 3 3       3                                                                              N                                                                              3                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 2 0 0 --                                                                               0 0 1 0 0 0 0 0 3       0                                                                              0                                                                              3                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 3 0 1 --                                                                               0 0 0 0 0 N 0 0 N       N                                                                              N                                                                              3                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 0 0 0 N 0 0 N       0                                                                              0                                                                              3                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               N N 0 N --                                                                               0 0 0 0 0 1 0 0 N       0                                                                              N                                                                              N                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               1 N 0 0 --                                                                               0 0 0 0 0 0 0 0 2       0                                                                              N                                                                              N                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 1 0 0 0 0 0 0       0                                                                              0                                                                              2                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     12  5.6050                                                                             0 --                                                                               --                                                                               0 3 2 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         5.6050                                                                             3 --                                                                               --                                                                               2 3 3 3 --                                                                               3 2 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 0 3 0 --                                                                               0 2 3 3 0 3 3 3 3       3                                                                              3                                                                              2                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               1 0 3 3 --                                                                               3 2 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               1 1 1 0 --                                                                               0 0 3 1 0 2 3 3 2       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 2 3 1 --                                                                               2 3 3 3 1 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 1 1 0 --                                                                               0 0 3 1 0 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             N --                                                                               --                                                                               0 1 1 1 --                                                                               0 1 3 3 0 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             1 --                                                                               --                                                                               0 1 2 0 --                                                                               0 0 0 1 0 3 0 1 3       2                                                                              3                                                                              3                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             N --                                                                               --                                                                               0 2 0 1 --                                                                               0 2 3 3 1 1 3 3 3       3                                                                              0                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 1 0 0 1 0 1 3       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 1 2 0 0 1 3 2       0                                                                              0                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             N --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              1                                                                              1                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 0 0 1 --                                                                               0 0 N 2 0 1 1 1 N       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             1 --                                                                               --                                                                               0 0 0 1 --                                                                               0 0 1 0 0 0 0 0 3       0                                                                              N                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              2                                                                              1                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     14  5.6050                                                                             3 --                                                                               --                                                                               0 0 3 2 --                                                                               0 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             1 --                                                                               --                                                                               N N 3 N --                                                                               1 2 3 3 2 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               N 0 3 0 --                                                                               1 1 3 3 0 1 3 3 2       3                                                                              0                                                                              1                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               N 0 N 1 --                                                                               0 0 0 1 0 0 3 0 2       1                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             1 --                                                                               --                                                                               N 1 N 0 --                                                                               0 0 0 1 0 0 0 0 1       0                                                                              0                                                                              0                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             1 --                                                                               --                                                                               N 0 N 0 --                                                                               0 0 0 1 1 0 0 1 0       1                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               N 0 N 0 --                                                                               0 0 0 1 1 0 0 0 0       0                                                                              0                                                                              0                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             N --                                                                               --                                                                               N 1 N 1 --                                                                               0 0 0 N N 0 0 N 0       N                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     15  5.6050                                                                             3 --                                                                               --                                                                               1 1 3 1 --                                                                               1 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             2 --                                                                               --                                                                               N 0 3 3 --                                                                               0 3 3 3 2 3 N 3 3       3                                                                              0                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               2 0 3 1 --                                                                               0 3 3 3 2 3 3 3 3       3                                                                              1                                                                              1                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             1 --                                                                               --                                                                               1 0 3 2 --                                                                               0 1 3 3 1 2 3 3 3       3                                                                              1                                                                              2                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               N 1 N 0 --                                                                               1 0 1 1 1 0 0 3 3       3                                                                              N                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             N --                                                                               --                                                                               N 0 N 2 --                                                                               1 0 0 2 1 0 1 1 3       1                                                                              1                                                                              0                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               N 0 N 1 --                                                                               0 0 0 1 0 0 0 0 2       3                                                                              N                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             1 --                                                                               --                                                                               N 0 N 1 --                                                                               0 0 0 1 0 0 1 0 1       0                                                                              N                                                                              N                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               N 1 N 0 --                                                                               0 0 0 0 0 0 0 0 3       0                                                                              1                                                                              N                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     16  5.6050                                                                             1 --                                                                               --                                                                               0 0 0 1 --                                                                               0 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               N 0 N 1 --                                                                               0 0 1 1 0 0 1 3 1       3                                                                              3                                                                              0                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               N 0 N 2 --                                                                               0 0 N 2 0 1 N 3 1       3                                                                              1                                                                              1                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             1 --                                                                               --                                                                               N 0 N 1 --                                                                               1 0 0 2 1 0 1 3 2       3                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               N 0 N 1 --                                                                               0 0 0 1 0 1 1 0 2       1                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               N 0 N 1 --                                                                               1 0 0 1 0 0 1 1 0       1                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             N --                                                                               --                                                                               N 0 N N --                                                                               N 0 0 1 0 0 1 0 1       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             N --                                                                               --                                                                               N 0 N N --                                                                               0 0 N N 1 0 N N 1       N                                                                              N                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     17  5.6050                                                                             0 --                                                                               --                                                                               0 2 0 0 --                                                                               1 2 2 2 0 0 3 3 3       3                                                                              2                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 0 0 0 0 0 0 1       0                                                                              0                                                                              1                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     19  5.6050                                                                             1 --                                                                               --                                                                               1 3 3 3 --                                                                               3 3 3 3 2 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               1 3 2 2 --                                                                               2 3 3 3 1 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 2 1 2 --                                                                               1 2 1 3 1 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 1 1 1 --                                                                               0 1 0 1 1 3 3 2 3       3                                                                              2                                                                              3                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 1 1 0 --                                                                               0 0 0 0 0 2 2 2 3       3                                                                              1                                                                              2                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 1 1 1 3       3                                                                              0                                                                              2                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 2       1                                                                              0                                                                              2                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     20  5.6050                                                                             0 --                                                                               --                                                                               1 1 1 1 --                                                                               2 2 0 2 0 2 2 3 3       3                                                                              1                                                                              3                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 0 1 0 0 1 0 1       2                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              N                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     21  5.6050                                                                             0 --                                                                               --                                                                               0 2 0 0 --                                                                               0 1 1 1 0 0 2 1 3       2                                                                              0                                                                              3                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              N                                                                              N                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     23  5.6050                                                                             0 --                                                                               --                                                                               0 2 1 1 --                                                                               0 2 0 1 1 3 3 2 3       3                                                                              1                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 3 0 1 --                                                                               3 2 2 3 0 3 3 3 3       3                                                                              1                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 1 N 0 2       3                                                                              0                                                                              0                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 N 0 0 --                                                                               0 0 0 0 0 1 N 0 0       1                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     24  5.6050                                                                             2 --                                                                               --                                                                               0 3 3 3 --                                                                               3 3 3 3 2 3 3 3 3       3                                                                              2                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 3 0 0 --                                                                               2 2 2 3 1 3 3 3 3       3                                                                              2                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             N --                                                                               --                                                                               0 3 0 0 --                                                                               1 1 1 2 1 2 3 3 3       3                                                                              N                                                                              N                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 1 0 0 2 3 1 2       2                                                                              0                                                                              3                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 0 0 0 1 N 2 2       3                                                                              0                                                                              N                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 1 0 0 0       0                                                                              0                                                                              2                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 1 N 0 0       0                                                                              0                                                                              0                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 N 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               0 N 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              N                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     25  11.2100                                                                            --                                                                               --                                                                               0 --                                                                               0 --                                                                               --                                                                               --                                                                               --                                                                               0 --                                                                               --                                                                               --                                                                               0 --                                                                               --                                                                               --      0                                                                              --                                                                             --                                                                             --                                                                               0 0 0 0    --                                                                        0                          11.2100                                                                            0 0 --                                                                               0 --                                                                               0 --                                                                               --                                                                               0 --                                                                               0 --                                                                               0 --                                                                               --                                                                               1 0       --                                                                             --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   0                                                                         --                         5.6050                                                                             0 0 --                                                                               0 --                                                                               0 --                                                                               --                                                                               0 --                                                                               0 --                                                                               0 --                                                                               --                                                                               1 0       --                                                                             --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   0                                                                         --                         5.6050                                                                             --                                                                               --                                                                               0 --                                                                               0 --                                                                               --                                                                               --                                                                               --                                                                               0 --                                                                               --                                                                               --                                                                               0 --                                                                               --                                                                               --      0                                                                              --                                                                             --                                                                             --                                                                               0 0 0 0    --                                                                        0                          1.1210                                                                             0 0 --                                                                               0 --                                                                               0 --                                                                               --                                                                               0 --                                                                               0 --                                                                               0 --                                                                               --                                                                               0 0       --                                                                             --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   0                                                                         --                         1.1210                                                                             --                                                                               --                                                                               0 --                                                                               0 --                                                                               --                                                                               --                                                                               --                                                                               0 --                                                                               --                                                                               --                                                                               0 --                                                                               --                                                                               --      0                                                                              --                                                                             --                                                                             --                                                                               0 0 0 0    --                                                                        0                          0.2803                                                                             --                                                                               --                                                                               0 --                                                                               0 --                                                                               --                                                                               --                                                                               --                                                                               0 --                                                                               --                                                                               --                                                                               0 --                                                                               --                                                                               --      0                                                                              --                                                                             --                                                                             --                                                                               0 0 0 0    --                                                                        0                          0.2803                                                                             0 0 --                                                                               0 --                                                                               0 --                                                                               --                                                                               0 --                                                                               0 --                                                                               0 --                                                                               --                                                                               0 0       --                                                                             --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   0                                                                         --                         0.0701                                                                             --                                                                               --                                                                               0 --                                                                               0 --                                                                               --                                                                               --                                                                               --                                                                               0 --                                                                               --                                                                               --                                                                               0 --                                                                               --                                                                               --      0                                                                              --                                                                             --                                                                             --                                                                               0 0 0 0    --                                                                        0                          0.0701                                                                             0 0 --                                                                               0 --                                                                               0 --                                                                               --                                                                               0 --                                                                               0 --                                                                               0 --                                                                               --                                                                               0 0       --                                                                             --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   0                                                                         --                     26  5.6050                                                                             2 --                                                                               --                                                                               0 3 3 3 3 --                                                                               3 2 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 3 --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 1 1 0 --                                                                               1 1 3 3 1 1 3 3 3       3                                                                              N                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               1 0 2 3 0 1 3 3 3       3                                                                              0                                                                              2                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 N 0 0 --                                                                               0 0 0 0 0 0 1 0 1       1                                                                              N                                                                              1                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 N N 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     27  5.6050                                                                             3 --                                                                               --                                                                               1 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             1 --                                                                               --                                                                               0 3 1 3 --                                                                               3 3 3 3 2 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 2 2 1 --                                                                               2 1 3 3 1 2 3 3 3       3                                                                              2                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2603                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               1 0 3 1 0 3 2 2 3       1                                                                              0                                                                              2                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 N 0 1 --                                                                               2 0 3 3 0 2 3 3 3       3                                                                              0                                                                              N                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               1 0 2 0 0 0 1 1 3       1                                                                              0                                                                              0                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 N 0 1       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              N                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     28  5.6050                                                                             0 --                                                                               --                                                                               0 3 1 2 --                                                                               2 0 2 3 1 2 3 3 3       3                                                                              2                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 2 0 0 --                                                                               0 0 1 1 0 0 0 0 2       2                                                                              0                                                                              1                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     29  5.6050                                                                             1 --                                                                               --                                                                               0 3 2 3 --                                                                               3 3 3 3 2 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 3 0 2 --                                                                               2 2 1 3 1 3 3 3 3       3                                                                              1                                                                              3                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5606                                                                             0 --                                                                               --                                                                               0 3 0 0 --                                                                               0 2 2 1 0 3 3 3 3       3                                                                              0                                                                              2                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 1 0 3 1 3 3       3                                                                              0                                                                              0                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 1 1       1                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 N 0 0 --                                                                               0 0 0 0 0 0 0 0 0       1                                                                              0                                                                              N                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 N 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              N                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     30  5.6050                                                                             3 --                                                                               --                                                                               1 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             1 --                                                                               --                                                                               0 3 1 3 --                                                                               3 3 3 3 2 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             1 --                                                                               --                                                                               0 3 2 3 --                                                                               3 3 3 2 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 2 0 1 --                                                                               2 3 2 3 1 3 3 3 3       3                                                                              N                                                                              3                                                                              3 --                                                                               -- 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                         --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 0 3 0 3 2 2 3       3                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 0 1 0 0 0 1 1       3                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     31  5.6050                                                                             3 --                                                                               --                                                                               0 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 3 2 2 --                                                                               3 2 3 3 2 3 3 3 3       3                                                                              2                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 3 2 2 --                                                                               2 1 2 3 2 3 3 3 3       3                                                                              1                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 1 1 0 --                                                                               1 1 2 3 1 2 3 3 3       3                                                                              0                                                                              1                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               1 0 2 2 0 2 3 2 3       3                                                                              0                                                                              N                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 1 0 0 0 0 2       2                                                                              0                                                                              0                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     32  5.6050                                                                             0 --                                                                               --                                                                               0 0 1 0 --                                                                               0 0 0 0 1 1 1 1 3       3                                                                              0                                                                              1                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       1                                                                              0                                                                              0                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     33  5.6050                                                                             2 --                                                                               --                                                                               0 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --       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                   --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 3 1 3 --                                                                               2 2 3 3 1 3 3 3 3       3                                                                              1                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 1 0 1 --                                                                               2 2 3 3 0 3 3 3 3       3                                                                              1                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 1 3 0 2 3 3 3       3                                                                              0                                                                              1                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               1 0 1 1 0 3 3 1 3       3                                                                              0                                                                              N                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 N 0 0 1 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 N 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 N 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     34  5.6050                                                                             3 --                                                                               --                                                                               3 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 --                                                                               --                                                                               1 3 2 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             2 --                                                                               --                                                                               0 3 2 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               1 3 3 3 --                                                                               3 3 3 3 1 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 0 1 3 --                                                                               3 3 2 3 1 3 3 3 3       3                                                                              1                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               1 0 1 0 --                                                                               1 3 1 1 0 3 3 3 3       3                                                                              1                                                                              3                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               1 0 0 0 --                                                                               0 1 1 1 0 3 3 3 3       3                                                                              0                                                                              3                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 1 1 2 1       3                                                                              0                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 1 0 1 0 0 0       1                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     36  5.6050                                                                             0 --                                                                               --                                                                               0 1 1 0 --                                                                               1 3 3 3 1 3 3 3 3       3                                                                              1                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               1 1 0 0 --                                                                               1 1 1 1 0 1 3 3 3       3                                                                              0                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 0 1 0 --                                                                               0 0 0 0 0 0 0 1 2       3                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 1 0       0                                                                              0                                                                              0                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     39  5.6050                                                                             0 --                                                                               --                                                                               1 1 1 1 --                                                                               2 2 1 2 0 3 2 3 3       3                                                                              2                                                                              3                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         2.8025                                                                             0 --                                                                               --                                                                               0 1 1 1 --                                                                               1 1 0 1 0 3 3 3 3       3                                                                              0                                                                              2                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 1 0 1 0 1 1       2                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 0 0 0 1 0 0 1       2                                                                              1                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     40  5.6050                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               1 1 1 2 0 0 3 3 0       1                                                                              3                                                                              0                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               1 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              3                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5805                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              3                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 2 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              N                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               1 N 0 0 --                                                                               0 0 0 0 0 0 0 0 N       0                                                                              0                                                                              3                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     41  5.6050                                                                             2 --                                                                               --                                                                               0 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             1 --                                                                               --                                                                               0 3 2 1 --                                                                               3 3 2 3 3 3 3 3 3       3                                                                              2                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 2 2 2 --                                                                               2 2 2 3 1 3 3 3 3       3                                                                              2                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 2 2 1 --                                                                               2 0 2 2 1 2 3 3 3       3                                                                              0                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 2 0 0 --                                                                               0 1 2 2 0 2 2 3 3       3                                                                              0                                                                              2                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             1 --                                                                               --                                                                               0 2 0 0 --                                                                               0 0 0 2 0 0 3 3 3       3                                                                              1                                                                              2                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 2 1 0 --                                                                               0 0 0 1 0 1 2 0 2       1                                                                              2                                                                              1                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 2 0 N --                                                                               1 0 0 1 0 1 1 1 0       1                                                                              0                                                                              N                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     42  5.6050                                                                             3 --                                                                               --                                                                               2 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 --                                                                               --                                                                               0 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             3 --                                                                               --                                                                               1 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             2 --                                                                               --                                                                               0 3 2 3 --                                                                               3 3 3 3 1 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 2 2 3 --                                                                               2 3 3 3 2 3 3 3 3       3                                                                              2                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 2 1 2 --                                                                               2 1 1 2 0 3 3 3 3       3                                                                              2                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 1 0 1 --                                                                               2 0 1 0 0 2 3 3 3       3                                                                              1                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 0 2 0 1 3 3 3       3                                                                              0                                                                              3                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 2 3 2 3       3                                                                              0                                                                              1                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     43  5.6050                                                                             3 --                                                                               --                                                                               2 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             2 --                                                                               --                                                                               0 3 2 3 --                                                                               3 3 3 3 1 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             2 --                                                                               --                                                                               0 3 0 2 --                                                                               3 3 3 3 1 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 1 0 1 --                                                                               2 2 1 2 1 3 3 3 3       3                                                                              2                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               2 2 1 2 0 2 3 3 3       3                                                                              2                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               1 1 1 1 0 2 3 3 3       3                                                                              1                                                                              2                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               1 0 0 0 0 0 2 1 3       3                                                                              0                                                                              1                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 1 0 1 1 2 2 3 3       3                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 2 0 1       2                                                                              0                                                                              0                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     44  5.6050                                                                             3 --                                                                               --                                                                               1 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             1 --                                                                               --                                                                               0 3 2 2 --                                                                               3 3 3 3 2 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 1 1 1 --                                                                               2 3 2 2 1 3 3 3 3       3                                                                              2                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 0 1 1 --                                                                               2 3 2 3 1 3 3 3 3       3                                                                              1                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 1 1 0 0 3 3 3 3       3                                                                              0                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 3 3 3 3       3                                                                              1                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               1 0 0 0 --                                                                               0 0 0 0 0 2 2 1 1       2                                                                              1                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 2 0 1 0       0                                                                              1                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              N                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     45  5.6050                                                                             1 --                                                                               --                                                                               1 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3          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               3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 3 1 1 --                                                                               2 3 1 0 0 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               1 1 0 1 --                                                                               2 1 0 0 0 3 3 3 3       3                                                                              2                                                                              2                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 3 3 2 1       3                                                                              0                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 N 1 1 0       3                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 1 0 0 0       2                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 2 0 0 0       1                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 2 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     46  5.6050                                                                             0 --                                                                               --                                                                               0 1 1 2 --                                                                               3 3 3 3 1 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 0 1 0 --                                                                               2 1 0 0 0 3 3 3 3       3                                                                              0                                                                              2                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 1 1 0 --                                                                               1 2 0 0 0 3 2 3 3       3                                                                              1                                                                              2                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 1 1 1 --                                                                               1 1 0 0 0 2 1 1 1       3                                                                              0                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 0 0 0 2 0 0 0       2                                                                              0                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 1 0 0 0 2 0 0 0       2                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               1 2 1 1 --                                                                               1 1 0 0 0 2 0 0 0       2                                                                              1                                                                              2                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 2 1 0 --                                                                               0 1 0 0 0 1 0 1 0       0                                                                              1                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     47  5.6050                                                                             3 --                                                                               --                                                                               2 3 2 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         5.6050                                                                             3 1 3 2 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             2 1 3 0 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             1 --                                                                               --                                                                               1 3 1 3 --                                                                               3 3 3 3 2 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             1 --                                                                               --                                                                               0 2 1 2 --                                                                               2 3 2 3 2 3 3 3 3       3                                                                              2                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 1 0 2 --                                                                               2 2 2 3 1 3 3 3 3       3                                                                              2                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 0 3 0 3 2 2 --                                                                               2 3 2 3 1 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 1 0 1 --                                                                               --                                                                               2 2 0 1 0 3 3 3       3                                                                              2                                                                              3                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 1 0 1 --                                                                               1 1 0 0 0 3 3 2 3       3                                                                              2                                                                              2                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             1 0 0 0 1 0 0 --                                                                               0 2 0 2 0 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               2 --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 0 0 0 3 2 1 3       3                                                                              1                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 2 1 1 0       1                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 N 0 0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 1       0                                                                              --                                                                             --                                                                             --                                                                               2 --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 1 0 1 1       1                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     48  5.6050                                                                             3 --                                                                               --                                                                               1 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                  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                                                                         --   --                                                                        --                         1.1210                                                                             2 --                                                                               --                                                                               1 3 2 1 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             2 --                                                                               --                                                                               0 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 3 2 2 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             1 --                                                                               --                                                                               0 1 1 2 --                                                                               2 2 3 2 2 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               N 2 1 3 --                                                                               3 1 3 3 1 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 3 2 2 --                                                                               3 3 3 3 --                                                                               1 3 3 3       3                                                                              N                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 2 0 1 --                                                                               2 1 1 3 1 3 3 3 3       3                                                                              1                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 N 3 0 2 N 3 3       3                                                                              0                                                                              N                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 3 0 0 3 3 2 3       2                                                                              1                                                                              3                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 0 0 2 --                                                                               0 0 1 3 0 2 3 3 3       3                                                                              0                                                                              1                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 1 0 2 0 3 3 3 3       3                                                                              N                                                                              N                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 3 0 0 1 2 0 3       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 2 0 --                                                                               1 0 2 0 0 0 1 0 3       1                                                                              N                                                                              1                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 2 0 1 2       3                                                                              0                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 1 0 0 1       1                                                                              0                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               0 1 1 N --                                                                               0 0 1 0 0 0 0 0 2       0                                                                              1                                                                              0                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0044                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     49  5.6050                                                                             3 --                                                                               --                                                                               0 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.12101                                                                            0 --                                                                               --                                                                               0 3 1 2 --                                                                               2 3 3 3 1 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 3 2 2 --                                                                               2 2 1 1 1 3 3 3 3       3                                                                              2                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 3 1 2 --                                                                               2 0 0 0 0 3 3 3 3       3                                                                              0                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 0 1 1 --                                                                               1 1 0 0 0 1 3 3 3       3                                                                              0                                                                              2                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               1 0 0 0 0 1 3 2 3       3                                                                              0                                                                              1                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 1 1 2 2       3                                                                              0                                                                              1                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 1 0 0 2       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     50  5.6050                                                                             3 --                                                                               --                                                                               2 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             2 --                                                                               --                                                                               1 3 2 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             1 --                                                                               --                                                                               0 3 1 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 3 2 2 --                                                                               3 3 0 2 1 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               1 2 1 1 --                                                                               2 2 2 1 1 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 2 1 1 --                                                                               2 1 2 1 0 1 3 3 3       3                                                                              N                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 3 0 1 --                                                                               2 1 2 0 0 N 3 3 3       3                                                                              N                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 2 0 0 --                                                                               1 0 0 0 0 1 1 3 3       3                                                                              N                                                                              3                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 0 0 0 0 0 2 3       2                                                                              0                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0044                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               1 0 0 0 0 0 1 2 1       1                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     51  5.6050                                                                             3 --                                                                               --                                                                               3 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             2 --                                                                               --                                                                               0 3 3 3 --                                                                               3 3 3 3 2 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             1 --                                                                               --                                                                               0 3 2 2 --                                                                               3 3 3 3 2 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 3 2 1 --                                                                               3 1 3 3 0 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 3 0 0 --                                                                               2 3 3 3 0 3 3 3 3       3                                                                              2                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 N 0 0 --                                                                               0 3 3 2 0 3 3 3 3       3                                                                              N                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 3 0 0 --                                                                               0 0 1 0 0 3 3 2 3       3                                                                              1                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 N 0 0 3       2                                                                              0                                                                              N                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 3 0 0 2       0                                                                              0                                                                              3                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     52  5.6050                                                                             3 --                                                                               --                                                                               2 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 --                                                                               --                                                                               1 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             3 --                                                                               --                                                                               0 3 2 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             1 --                                                                               --                                                                               0 3 2 2 --                                                                               3 3 3 3 1 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             1 --                                                                               --                                                                               3 3 2 1 --                                                                               3 2 3 3 1 3 3 3 3       3                                                                              2                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             1 --                                                                               --                                                                               0 2 2 1 --                                                                               3 1 3 2 0 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 N 0 1 --                                                                               1 0 2 0 0 3 3 3 3       3                                                                              2                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 N 0 0 --                                                                               0 0 1 0 0 2 3 2 3       3                                                                              1                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 0 0 0 2 0 0 3       2                                                                              0                                                                              N                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     53  5.6050                                                                             3 --                                                                               --                                                                               1 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             1 --                                                                               --                                                                               0 3 2 2 --                                                                               3 3 3 3 2 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 3 1 1 --                                                                               3 3 3 3 1 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                       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   --                                                                               --   --                                                                        --                         0.1401                                                                             1 --                                                                               --                                                                               0 2 0 0 --                                                                               0 1 0 1 0 3 3 3 3       3                                                                              1                                                                              3                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 0 0 0 3 0 0 3       3                                                                              1                                                                              2                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 2 0 0 2       1                                                                              0                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 N 0 0 --                                                                               0 0 0 0 0 2 0 0 1       0                                                                              0                                                                              N                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     54  5.6050                                                                             3 --                                                                               --                                                                               1 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             1 --                                                                               --                                                                               0 3 3 3 --                                                                               3 3 3 3 1 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 3 2 3 --                                                                               2 3 3 3 1 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 3 1 1 --                                                                               1 2 3 1 0 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               1 1 0 1 --                                                                               1 1 2 1 0 2 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 0 0 0 2 2 3 3       3                                                                              1                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 1 1 2 3       3                                                                              0                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 2 0 0 3       0                                                                              0                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     55  5.6050                                                                             1 --                                                                               --                                                                               0 3 2 2 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 2 1 0 2 3 3 3       3                                                                              1                                                                              2                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 0 0 0 1 1 3 3       3                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 N 0 0 0 N 1 3 3       3                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 1 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     56  11.2100                                                                            0 --                                                                               --                                                                               0 3 0 0 --                                                                               1 1 0 1 0 3 3 3 3       3                                                                              3                                                                              3                                                                              2 --                                                                               --                                                                               -- 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                         --   --                                                                        --                         2.8025                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 2 2 0 2       0                                                                              0                                                                              2                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 1 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     57  5.6050                                                                             0 --                                                                               --                                                                               0 3 1 0 --                                                                               2 2 3 1 0 3 3 3 3       3                                                                              3                                                                              3                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 1 0 0 0 3 3 0 3       1                                                                              2                                                                              3                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 1 0 0 3       0                                                                              0                                                                              3                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 1 0 0 3       0                                                                              1                                                                              3                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               1 N 0 0 --                                                                               0 0 0 0 0 N 0 0 3       0                                                                              N                                                                              N                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 3       0                                                                              0                                                                              3                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               1 0 0 0 --                                                                               0 0 0 0 0 0 0 0 1       0                                                                              0                                                                              3                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     58  5.60                                                                               0 --                                                                               --                                                                               0 3 2 2 --                                                                               3 3 2 3 2 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.12                                                                               0 --                                                                               --                                                                               0 0 0 0 --                                                                               1 1 0 0 0 1 3 3 2       3                                                                              2                                                                              2                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.56                                                                               0 --                                                                               --                                                                               0 N 0 0 --                                                                               0 0 0 0 0 0 2 1 N       3                                                                              1                                                                              N                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.28                                                                               0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 2       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.14                                                                               0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 N 0 0 N       0                                                                              0                                                                              N                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.07                                                                               0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 a 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     59  5.60                                                                               3 --                                                                               --                                                                               0 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.12                                                                               0 --                                                                               --                                                                               0 N 1 0 --                                                                               2 1 3 1 0 2 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.56                                                                               0 --                                                                               --                                                                               0 3 0 0 --                                                                               0 0 1 1 0 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.28                                                                               0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 0 0 0 2 2 2 3       0                                                                              1                                                                              3                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.14                                                                               0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 1 0 3       0                                                                              0                                                                              N                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     60  5.60                                                                               3 --                                                                               --                                                                               2 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.12                                                                               3 --                                                                               --                                                                               0 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.56                                                                               3 --                                                                               --                                                                               0 3 2 2 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.28                                                                               1 --                                                                               --                                                                               0 3 1 1 --                                                                               2 3 3 3 2 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.14                                                                               0 --                                                                               --                                                                               0 3 0 2 --                                                                               2 2 2 1 0 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.07                                                                               N --                                                                               --                                                                               0 3 1 1 --                                                                               1 0 1 0 0 3 3 3 3       3                                                                              3                                                                              2                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.35                                                                               0 --                                                                               --                                                                               0 N 0 0 --                                                                               0 0 1 0 0 3 1 3 3       3                                                                              1                                                                              N                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.018                                                                              0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              2                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.009                                                                              0 --                                                                               --                                                                               0 N 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              N                                                                              N                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                     61  5.60                                                                               3 --                                                                               --                                                                               0 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.12                                                                               3 --                                                                               --                                                                               0 3 3 3 --                                                                               3 3 2 3 3 3 3 3 3       3                                                                              3                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         3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.28                                                                               0 --                                                                               --                                                                               0 3 1 1 --                                                                               1 3 0 3 3 3 3 3 3       3                                                                              2                                                                              3                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.14                                                                               0 --                                                                               --                                                                               0 3 0 1 --                                                                               0 2 0 3 1 3 3 3 3       3                                                                              1                                                                              3                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.07                                                                               0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 1 3 0 3 0 3 3       3                                                                              0                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.035                                                                              0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 0 0 0 3 N 3 3       3                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.08                                                                               0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 N 0 0 2 0 0 3       3                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.009                                                                              0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 2 0 0 3       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     62  5.6 3 --                                                                               --                                                                               2 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.12                                                                               2 --                                                                               --                                                                               0 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.56                                                                               0 --                                                                               --                                                                               0 0 2 1 --                                                                               2 3 3 3 3 3 3 3 3       3                                                                              2                                                                              3                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.28                                                                               0 --                                                                               --                                                                               0 N 0 2 --                                                                               2 1 1 3 1 3 3 3 3       3                                                                              3                                                                              3                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.14                                                                               0 --                                                                               --                                                                               0 0 2 0 --                                                                               1 0 0 1 0 3 3 3 3       3                                                                              1                                                                              3                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.07                                                                               0 --                                                                               --                                                                               0 N 0 0 --                                                                               1 0 0 0 0 3 3 2 3       2                                                                              1                                                                              3                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.035                                                                              0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 0 0 0 3 2 0 3       0                                                                              1                                                                              3                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.018                                                                              0 --                                                                               --                                                                               0 N 1 1 --                                                                               0 0 0 0 0 1 0 0 3       0                                                                              N                                                                              3                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.009                                                                              0 --                                                                               --                                                                               0 N 0 0 --                                                                               0 0 0 0 0 3 0 0 3       0                                                                              N                                                                              3                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     63  5.60                                                                               3 --                                                                               --                                                                               1 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.12                                                                               2 --                                                                               --                                                                               0 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                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   2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.14                                                                               0 --                                                                               --                                                                               N 0 0 0 --                                                                               0 0 0 3 1 3 3 3 1       3                                                                              0                                                                              2                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.07                                                                               0 --                                                                               --                                                                               0 N 0 1 --                                                                               0 0 2 3 0 1 3 3 N       3                                                                              N                                                                              N                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.035                                                                              0 --                                                                               --                                                                               0 0 0 1 --                                                                               0 0 1 2 0 0 0 2 0       2                                                                              0                                                                              N                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.18                                                                               0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 N       0                                                                              0                                                                              N                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.009                                                                              0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     64  5.60                                                                               1 --                                                                               --                                                                               1 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.12                                                                               1 --                                                                               --                                                                               0 1 3 3 --                                                                               1 3 3 3 2 3 3 3 3       3                                                                              3                                                                              0                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.56                                                                               0 --                                                                               --                                                                               0 1 3 1 --                                                                               1 3 3 3 2 3 3 3 3       3                                                                              0                                                                              0                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.28                                                                               0 --                                                                               --                                                                               0 2 1 2 --                                                                               0 0 3 2 0 3 3 3 3       3                                                                              0                                                                              0                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.14                                                                               0 --                                                                               --                                                                               0 2 0 0 --                                                                               0 1 1 0 0 2 3 3 3       3                                                                              0                                                                              0                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.07                                                                               0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 1 1 1 0 1 0 2 3       3                                                                              0                                                                              N                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.035                                                                              0 --                                                                               --                                                                               0 1 0 1 --                                                                               0 0 2 0 0 2 1 0 3       0                                                                              0                                                                              N                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.018                                                                              0 --                                                                               --                                                                               0 N 0 N --                                                                               0 0 1 0 0 1 0 0 3       0                                                                              0                                                                              1                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.009                                                                              0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 0 0 0 0 N 0 0       0                                                                              0                                                                              0                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     65  5.6050                                                                             2 --                                                                               --                                                                               2 3 2 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         5.6050                                                                             3 --                                                                               --                                                                               2 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             2 --                                                                               --                                                                               2 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.12                                                                               0 --                                                                               --                                                                               0 3 2 3 --                                                                               3 2 3 1 1 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.56                                                                               0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 1 N 0 1 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.56                                                                               1 --                                                                               --                                                                               2 2 1 3 --                                                                               3 2 3 3 2 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.28                                                                               0 --                                                                               --                                                                               1 3 0 2 --                                                                               2 2 3 3 1 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                       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   --                                                                               --   --                                                                        --                         0.14                                                                               0 --                                                                               --                                                                               N 3 1 2 --                                                                               0 0 3 3 1 1 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.14                                                                               0 --                                                                               --                                                                               0 N N 1 --                                                                               0 0 1 0 0 2 1 3 3       3                                                                              2                                                                              N                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.07                                                                               0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 1 0 3       1                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.07                                                                               0 --                                                                               --                                                                               N 1 1 1 --                                                                               1 0 1 2 1 2 2 3 3       3                                                                              1                                                                              0                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.35                                                                               0 --                                                                               --                                                                               N 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.35                                                                               N --                                                                               --                                                                               1 1 0 N --                                                                               1 0 N 1 1 1 1 1 3       2                                                                              N                                                                              N                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.018                                                                              N --                                                                               --                                                                               N 0 0 1 --                                                                               0 0 0 1 0 0 0 0 0       0                                                                              0                                                                              0                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.018                                                                              0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.009                                                                              0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 1 0 0 1       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     66  5.6 0 --                                                                               --                                                                               0 3 1 1 --                                                                               2 2 3 3 2 3 3 3 3       3                                                                              2                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.12                                                                               0 --                                                                               --                                                                               0 3 0 1 --                                                                               2 0 3 1 3 0 3 3 2       3                                                                              3                                                                              3                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.56                                                                               0 --                                                                               --                                                                               0 2 0 0 --                                                                               1 0 2 1 1 0 3 3 3       3                                                                              1                                                                              3                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.28                                                                               0 --                                                                               --                                                                               0 2 0 1 --                                                                               0 0 0 1 1 N 3 3 3       3                                                                              0                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.14                                                                               0 --                                                                               --                                                                               0 2 0 1 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              N                                                                              2                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.07                                                                               0 --                                                                               --                                                                               0 3 0 N --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              N                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     67  5.6 0 --                                                                               --                                                                               0 3 2 3 --                                                                               3 3 3 1 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.12                                                                               0 --                                                                               --                                                                               0 3 0 3 --                                                                               3 2 3 3 2 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               1 3 N 1 --                                                                               0 2 2 2 0 1 3 3 3       3                                                                              2                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 3 0 1 --                                                                               0 0 0 0 0 0 3 3 2       2                                                                              3                                                                              3                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 3 0 N --                                                                               1 0 0 0 0 0 1 1 0       3                                                                              3                                                                              3                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               N 1 0 0 --                                                                               0 0 0 0 0 N 0 2 N       3                                                                              0                                                                              3                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 2 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              N                                                                              3                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 N 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              2                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                     68  5.6050                                                                             3 --                                                                               --                                                                               1 3 3 2 --                                                                               3 1 3 3 2 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 1 2 1 --                                                                               0 0 2 2 0 2 3 3 1       3                                                                              0                                                                              N                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 N 0 0 --                                                                               0 1 2 1 0 0 3 1 0       3                                                                              N                                                                              3                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               1 0 1 0 --                                                                               0 0 0 0 0 2 0 0 1       0                                                                              0                                                                              3                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 N 0 0 --                                                                               0 0 0 0 0 0 0 0 0       1                                                                              0                                                                              3                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 N 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     69  5.6050                                                                             0 --                                                                               --                                                                               0 3 1 1 --                                                                               1 2 3 1 2 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 3 0 0 --                                                                               0 0 2 0 0 2 3 2 3       3                                                                              1                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 3 0 0 --                                                                               0 0 0 0 0 0 1 1 0       1                                                                              0                                                                              3                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 1 0 N --                                                                               0 0 0 1 0 0 0 0 0       0                                                                              1                                                                              3                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               1 2 0 0 --                                                                               0 0 1 0 0 N 1 0 N       0                                                                              0                                                                              1                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 N 0 0 --                                                                               N 0 0 0 0 N 0 0 N       0                                                                              0                                                                              N                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     70  5.6050                                                                             0 --                                                                               --                                                                               0 3 2 1 --                                                                               0 0 3 0 1 2 3 3 3       3                                                                              1                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 3 1 0 --                                                                               0 0 2 0 0 0 2 3 0       1                                                                              0                                                                              3                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 2 1 0 --                                                                               0 0 0 0 0 N 0 1 0       0                                                                              0                                                                              3                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               1 N 0 0 --                                                                               0 0 N 0 0 1 N 0 0       0                                                                              0                                                                              3                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             1 --                                                                               --                                                                               0 N 0 N --                                                                               0 0 1 0 0 1 0 0 0       0                                                                              N                                                                              N                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 N 0 0 --                                                                               0 0 0 0 0 N N 0 N       0                                                                              1                                                                              3                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     71  5.6050                                                                             1 --                                                                               --                                                                               0 3 1 2 --                                                                               2 1 3 2 1 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 1 0 1 --                                                                               2 0 2 1 0 3 3 3 3       3                                                                              1                                                                              3                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 N 0 0 --                                                                               0 0 0 0 0 0 0 3 0       3                                                                              1                                                                              2                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             N --                                                                               --                                                                               0 2 0 0 --                                                                               0 0 0 0 0 2 0 1 3       0                                                                              1                                                                              3                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 N 0 0 --                                                                               0 0 0 0 0 0 0 0 3       0                                                                              0                                                                              3                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 N 0 0 --                                                                               0 0 N 0 0 1 0 0 1       0                                                                              N                                                                              3                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     72  11.2100                                                                            2 --                                                                               --                                                                               3 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         5.6050                                                                             0 --                                                                               --                                                                               0 3 2 2 --                                                                               1 1 3 3 1 3 3 3 3       3                                                                              1                                                                              2                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         2.8025                                                                             0 --                                                                               --                                                                               1 3 1 1 --                                                                               2 1 3 3 0 1 3 3 3       3                                                                              N                                                                              N                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               1 2 0 0 --                                                                               0 0 0 1 0 0 0 2 0       3                                                                              0                                                                              2                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               1 2 0 N --                                                                               1 0 0 0 0 1 0 0 0       0                                                                              2                                                                              3                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                     73  5.6050                                                                             0 --                                                                               --                                                                               0 3 3 1 --                                                                               0 2 3 3 1 3 3 3 3       3                                                                              2                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             1 --                                                                               --                                                                               0 3 1 1 --                                                                               0 0 1 0 1 3 2 3 3       3                                                                              1                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             N --                                                                               --                                                                               N 3 2 0 --                                                                               0 0 0 1 0 1 1 2 1       3                                                                              3                                                                              0                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 N 0 N --                                                                               N 0 N 0 0 N 1 0 1       0                                                                              N                                                                              N                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 3 0 0 --                                                                               0 0 0 N 0 0 0 0 0       1                                                                              1                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 0 0 N --                                                                               0 0 1 0 0 1 0 0 0       0                                                                              0                                                                              0                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     74  5.6050                                                                             3 --                                                                               --                                                                               3 0 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             1 --                                                                               --                                                                               0 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             1 --                                                                               --                                                                               0 3 3 3 --                                                                               3 3 3 3 2 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               1 3 3 2 --                                                                               3 2 3 2 0 3 3 3 3       3                                                                              1                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               N 3 3 1 --                                                                               0 2 3 3 0 3 3 3 3       3                                                                              1                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             1 --                                                                               --                                                                               0 3 0 0 --                                                                               0 2 3 1 0 3 3 3 3       3                                                                              2                                                                              3                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 2 0 2 3       3                                                                              1                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 0 0 0 1 0 0 2       2                                                                              0                                                                              0                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               0 N 0 0 --                                                                               0 0 0 0 0 0 0 0 1       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     75  5.6050                                                                             3 --                                                                               --                                                                               1 3 3 2 --                                                                               3 3 3 1 1 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 1 0 3 --                                                                               3 1 3 0 1 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             1 --                                                                               --                                                                               1 0 2 0 --                                                                               0 2 3 0 1 3 3 3 3       3                                                                              3                                                                              1                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             1 --                                                                               --                                                                               N 0 0 0 --                                                                               0 1 3 0 0 3 3 1 3       3                                                                              1                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 3 0 0 3 3 1 3       3                                                                              1                                                                              0                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 0 0 0 1 1 0 1       1                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 1 0 0 N       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     76  5.6050                                                                             1 --                                                                               --                                                                               0 0 0 0 --                                                                               0 3 3 3 3 3 3 3 3       3                                                                              2                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 N N 0 --                                                                               0 N 0 1 0 3 2 3 N       3                                                                              0                                                                              0                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 N N 0 --                                                                               0 N 0 1 0 3 2 3 N       3                                                                              0                                                                              0                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             N --                                                                               --                                                                               N 1 1 0 --                                                                               0 0 0 1 0 1 0 0 0       0                                                                              0                                                                              0                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               N 0 2 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              N                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               N 0 N 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               1 0 N 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 N 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               N 0 1 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     77  5.6050                                                                             3 --                                                                               --                                                                               0 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             2 --                                                                               --                                                                               0 0 3 0 --                                                                               0 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             2 --                                                                               --                                                                               1 N 3 N --                                                                               N 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 0 2 0 --                                                                               0 3 0 3 3 3 3 3 3       3                                                                              3                                                                              1                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             N --                                                                               --                                                                               0 0 1 0 --                                                                               0 0 0 3 1 3 3 3 3       3                                                                              3                                                                              1                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 0 N 0 --                                                                               0 1 0 3 0 3 0 3 3       3                                                                              3                                                                              0                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               N 0 N 0 --                                                                               0 0 0 0 0 3 1 3 3       3                                                                              1                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 1 0 3 3       3                                                                              0                                                                              0                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               0 N 0 0 --                                                                               0 0 0 0 0 0 0 0 0       3                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     78  5.6050                                                                             2 --                                                                               --                                                                               0 0 3 0 --                                                                               0 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             1 --                                                                               --                                                                               N 1 3 N --                                                                               N 2 3 3 1 3 3 3 3       3                                                                              3                                                                              3                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 0 2 0 --                                                                               0 N 2 3 0 3 3 3 3       3                                                                              2                                                                              1                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 3 3 3 3       0                                                                              3                                                                              0                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               1 0 1 0 --                                                                               0 0 0 0 0 1 0 3 3       N                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 2 0 0 3       1                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 2       1                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 N 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              N                                                                              0                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                     79  5.6050                                                                             3 --                                                                               --                                                                               0 0 3 1 --                                                                               1 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             1 --                                                                               --                                                                               N 1 0 0 --                                                                               0 0 0 1 1 3 3 1 3       1                                                                              0                                                                              2                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             2 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 N 0 2 3 2 3       0                                                                              0                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             2 --                                                                               --                                                                               0 N 0 0 --                                                                               0 0 0 0 0 1 1 0 2       0                                                                              N                                                                              N                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 1 0 N --                                                                               1 0 0 0 0 1 1 0 1       1                                                                              1                                                                              N                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             N --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 1 0 0 0 0 1       N                                                                              1                                                                              1                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              1                                                                              N                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                     80  11.2100                                                                            --                                                                               --                                                                               3 --                                                                               3 --                                                                               --                                                                               --                                                                               --                                                                               3 --                                                                               --                                                                               --                                                                               3 --                                                                               --                                                                               --      3                                                                              --                                                                             --                                                                             --                                                                               3 3 3 3    --                                                                        3                          11.2100                                                                            3 0 --                                                                               0 --                                                                               3 --                                                                               --                                                                               3 --                                                                               3 --                                                                               3 --                                                                               --                                                                               3 3       --                                                                             --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   3                                                                         --                         5.6050                                                                             --                                                                               --                                                                               3 --                                                                               3 --                                                                               --                                                                               --                                                                               --                                                                               3 --                                                                               --                                                                               --                                                                               3 --                                                                               --                                                                               --      3                                                                              --                                                                             --                                                                             --                                                                               3 3 1 2    --                                                                        3                          5.6050                                                                             3 0 --                                                                               0 --                                                                               3 --                                                                               --                                                                               3 --                                                                               3 --                                                                               3 --                                                                               --                                                                               3 3       --                                                                             --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   3                                                                         --                         5.6050                                                                             0 --                                                                               --                                                                               0 3 3 2 --                                                                               1 3 3 N 3 3 3 3 3       3                                                                              3                                                                              3                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 0 3 0 --                                                                               1 2 3 3 2 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 0 --                                                                               0 --                                                                               0 --                                                                               --                                                                               2 --                                                                               3 --                                                                               1 --                                                                               --                                                                               3 3       --                                                                             --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   3                                                                         --                         1.1210                                                                             --                                                                               --                                                                               3 --                                                                               3 --                                                                               --                                                                               --                                                                               --                                                                               2 --                                                                               --                                                                               --                                                                               3 --                                                                               --                                                                               --      3                                                                              --                                                                             --                                                                             --                                                                               3 3 0 0    --                                                                        3                          0.5605                                                                             0 --                                                                               --                                                                               0 1 3 0 --                                                                               1 3 3 3 1 1 3 3 3       3                                                                              2                                                                              1                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 N 2 0 --                                                                               0 2 3 3 1 3 3 3 3       3                                                                              1                                                                              2                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 0 --                                                                               0 --                                                                               0 --                                                                               --                                                                               0 --                                                                               1 --                                                                               0 --                                                                               --                                                                               3 3       --                                                                             --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   3                                                                         --                         0.2803                                                                             --                                                                               --                                                                               1 --                                                                               0 --                                                                               --                                                                               --                                                                               --                                                                               0 --                                                                               --                                                                               --                                                                               2 --                                                                               --                                                                               --      3                                                                              --                                                                             --                                                                             --                                                                               2 3 0 0    --                                                                        2                          0.1401                                                                             0 --                                                                               --                                                                               0 0 2 0 --                                                                               0 2 1 0 0 2 0 0 3       3                                                                              1                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 2 0 0 --                                                                               0 0 1 1 0 1 0 1 3       3                                                                              0                                                                              3                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             --                                                                               --                                                                               0 --                                                                               0 --                                                                               --       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                                                     0                          0.0701                                                                             0 0 --                                                                               0 --                                                                               0 --                                                                               --                                                                               0 --                                                                               0 --                                                                               0 --                                                                               --                                                                               2 3       --                                                                             --                                                                             --      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                  3                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               1 1 0 0 --                                                                               0 0 0 0 0 2 0 0 0       0                                                                              0                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               0 N 1 0 --                                                                               0 N 0 0 0 N N 0 N       1                                                                              0                                                                              N                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     81  5.6050                                                                             3 --                                                                               --                                                                               2 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                          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                                                 --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 N 3 2 --                                                                               1 3 3 3 3 3 3 3 3       3                                                                              3                                                                              N                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 1 3 2 1 3 3 3 3       3                                                                              1                                                                              1                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 N 0 1 --                                                                               0 3 3 2 0 3 3 3 3       3                                                                              2                                                                              N                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 1 0 1 --                                                                               0 3 2 0 0 3 3 3 3       3                                                                              N                                                                              N                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 3 0 0 0 0 0 1 0       3                                                                              0                                                                              0                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 3 1 0 0 0 0 0 N       2                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 2 0 0 0 0 0 0 0       0                                                                              0                                                                              N                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0044                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 3 0 0 0 0 0 0 N       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     82  5.6050                                                                             0 --                                                                               --                                                                               0 3 3 1 --                                                                               2 3 3 3 1 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               0 2 N 3 --                                                                               2 3 3 1 1 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 1 3 1 --                                                                               0 3 3 1 0 3 3 3 3       3                                                                              1                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 3 0 2 1 2 2 3 3       3                                                                              N                                                                              2                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 2 0 0 0 1 2 1 3       3                                                                              0                                                                              3                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 1 0 0 0 1 0 0 0       1                                                                              0                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 N 0 0 0 2 0 0 2       0                                                                              N                                                                              1                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 N 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               N 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     83  5.6050                                                                             1 --                                                                               --                                                                               1 3 0 2 --                                                                               2 3 3 2 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             1 --                                                                               --                                                                               0 2 0 2 --                                                                               1 1 3 3 1 3 3 3 3       3                                                                              1                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             1 --                                                                               --                                                                               0 3 1 1 --                                                                               0 1 2 1 0 1 1 2 3       3                                                                              1                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 1 N 1 --                                                                               0 0 0 0 0 0 0 1 0       1                                                                              0                                                                              1                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 0 1 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 N 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                     84  11.2100                                                                            1 0 2 N 3 0 2 0 0 3 3 3 2 3 3 3 N       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         11.2100                                                                            3 0 2 2 3 1 0 1 0 3 3 3 1 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         11.2100                                                                            0 0 2 1 1 2 1 0 0 3 3 3 3 1 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         5.6050                                                                             0 2 0 0 N 0 0 N 1 1 1 3 0 0 1 3 0       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 0 0 N 1 0 0 0 0 0 0 2 0 0 0 1 0       2                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     85  5.6050                                                                             3 3 3 0 3 3 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             2 0 3 0 3 0 3 3 3 2 3 2 1 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 1 3 0 3 0 2 2 2 1 2 1 0 3 3 2 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 0 0 0 2 0 0 0 0 0 1 0 0 3 1 0 3       2                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0351                                                                             0 0 0 0 N 0 0 1 0 0 2 0 0 1 0 0 2       1                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 N 0 0 1 0 1 N 1 0 N 0 0 N 0 0 N       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     86  5.6050                                                                             1 --                                                                               --                                                                               0 3 2 2 --                                                                               0 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               N 0 0 1 --                                                                               0 0 0 3 0 0 0 3 0       3                                                                              0                                                                              0                                                                              2 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               N 0 0 0 --                                                                               0 0 0 2 0 0 2 3 0       3                                                                              0                                                                              N                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               1 0 0 0 --                                                                               0 0 0 1 0 0 0 0 0       0                                                                              0                                                                              0                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             1 --                                                                               --                                                                               N 0 0 1 --                                                                               1 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               1 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              1 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               1 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              0 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               N 0 0 1 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              N                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                     88  11.2100                                                                            2 --                                                                               --                                                                               1 1 3 3 --                                                                               3 2 3 3 3 3 3 3 3       3                                                                              1                                                                              2                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         5.6050                                                                             0 --                                                                               --                                                                               0 0 1 1 --                                                                               1 0 3 3 3 3 3 3 3       3                                                                              0                                                                              0                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               1 0 0 0 --                                                                               0 0 0 0 0 0 3 0 0       0                                                                              1                                                                              0                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                     89  5.6050                                                                             3 --                                                                               --                                                                               0 1 3 3 --                                                                               3 2 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               N 0 N 3 --                                                                               3 0 2 1 0 2 3 3 3       3                                                                              3                                                                              3                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 1 3 1 --                                                                               1 0 0 3 0 0 3 3 3       0                                                                              0                                                                              0                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 1 0 0 --                                                                               0 0 1 2 0 N 0 0 2       0                                                                              N                                                                              0                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 1 0 0 0 0       0                                                                              1                                                                              0                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               N 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              0                                                                              0                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                     90  5.6050                                                                             0 1 1 2 2 1 0 1 1 1 0 1 2 1 2 1 3       1                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             N 0 1 0 0 0 1 1 0 0 1 0 0 0 1 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 N 0 0 N 0 0 1 0 0 1 N 0 0 N 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     91  5.6050                                                                             3 --                                                                               --                                                                               1 2 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 --                                                                               --                                                                               1 1 3 0 --                                                                               0 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 0 0 1 --                                                                               2 0 3 2 3 3 3 3 3       3                                                                              3                                                                              3                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 3 0 0 3 1 3 3       3                                                                              1                                                                              1                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               1 0 0 0 --                                                                               0 0 3 N 0 3 3 1 3       1                                                                              0                                                                              1                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               0 N 0 1 --                                                                               1 0 0 0 0 1 0 0 0       1                                                                              N                                                                              N                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0350                                                                             0 --                                                                               --                                                                               0 0 0 0 --                                                                               0 0 1 1 0 0 0 0 2       0                                                                              0                                                                              0                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               N 0 0 0 --                                                                               0 0 0 0 1 0 0 0 1       0                                                                              0                                                                              0                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 --                                                                               --                                                                               0 N 0 0 --                                                                               0 0 0 0 0 N 0 0 0       0                                                                              N                                                                              N                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                     92  5.6050                                                                             3 --                                                                               --                                                                               3 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             1 --                                                                               --                                                                               0 3 3 0 --                                                                               1 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.5605                                                                             0 --                                                                               --                                                                               0 2 3 0 --                                                                               1 3 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             2 --                                                                               --                                                                               0 1 3 N --                                                                               N 0 3 3 3 3 3 3 3       3                                                                              3                                                                              3                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.1401                                                                             0 --                                                                               --                                                                               N 1 2 2 --                                                                               1 2 3 3 3 3 3 3 3       3                                                                              2                                                                              3                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 --                                                                               --                                                                               1 1 3 1 --                                                                               0 0 3 3 3 3 2 3 3       3                                                                              1                                                                              3                                                                              N --                       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   --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 --                                                                               --                                                                               N 0 0 1 --                                                                               1 0 3 2 0 0 1 0 3       3                                                                              0                                                                              2                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             1 --                                                                               --                                                                               N 0 1 0 --                                                                               0 0 1 1 1 0 0 1 0       1                                                                              0                                                                              1                                                                              N --                                                                               --                                                                               --                                                                               --   --                                                                        --                     93  5.6050                                                                             3 1 3 0 3 3 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             2 0 3 0 3 3 3 3 3 3 3 3 2 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 0 1 0 3 0 1 3 0 1 3 1 0 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 1 0 N 1 0 0 2 0 0 1 0 0 2 1 0 3       1                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 0 0 0 0 N N N N 0 0 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     94  5.6050                                                                             2 0 3 0 3 3 2 2 3 2 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 0 1 0 1 3 2 2 0 1 3 3 1 2 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             N 1 1 N 0 1 0 1 0 0 2 0 0 2 1 0 3       1                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 0 0 N 0 1 0 0 0 0 0 0 0 0 N 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     95  5.6050                                                                             3 0 3 0 3 3 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 0 3 0 3 3 3 3 3 3 3 3 2 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 0 0 0 3 0 0 2 1 3 3 1 0 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             N 1 0 0 3 1 0 1 1 3 1 1 0 3 2 3 2       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0351                                                                             0 0 0 0 0 0 0 0 0 1 0 0 0 1 0 0 3       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             N 0 1 0 1 0 0 N 0 0 0 0 0 N 0 0 N       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             N N 0 N N 1 N 1 N 0 N 0 0 N 1 0 N       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     96  5.6050                                                                             0 0 0 0 2 0 0 0 0 2 N 1 0 1 0 3 N       2                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             1 N 0 N 1 0 0 0 1 0 1 0 0 N 1 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 0 0 0 2 0 0 1 1 0 0 0 0 2 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             1 0 0 N 0 0 0 1 0 0 N 0 0 N 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     97  5.6050                                                                             1 1 2 0 3 1 1 2 1 2 3 2 1 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 1 1 0 1 0 1 3 1 1 3 1 0 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 1 0 0 0 0 0 2 0 0 0 0 0 1 0 0 3       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 1 0 0 0 0 0 1 0 0 0 0 0 1 0 0 2       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     98  5.6050                                                                             3 2 3 0 3 3 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             1 2 3 1 3 3 2 2 3 3 3 3 2 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             1 1 1 N 3 1 1 3 0 1 3 0 0 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             1 0 0 0 3 0 0 1 0 1 0 1 0 2 0 1 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     99  5.6050                                                                             2 1 2 1 3 1 3 3 3 3 3 3 2 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 1 1 1 1 0 1 1 1 1 3 0 0 3 3 3 3       2                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 1 0 0 1 0 0 0 1 0 1 0 0 1 1 1 3       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             N N N N N N N N N N N N N N N N 1       N                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     100 11.2100                                                                            2 2 0 1 0 1 1 0 1 1 0 1 1 2 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         5.6050                                                                             1 1 1 1 0 1 1 0 3 0 0 0 0 1 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     101 5.6050                                                                             2 3 3 1 3 2 3 3 1 3 3 3 1 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             1 1 1 N 3 1 1 3 0 1 2 1 0 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 0 0 0 1 0 0 1 0 0 0 0 0 3 2 0 3       1                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 1 0 0 N 0 0 1 0 0 0 0 0 0 3 0 2       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     102 5.6050                                                                             3 3 3 N 3 3 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 2 3 N 3 3 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             2 3 3 N 3 1 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             2 2 2 N 3 1 3 1 3 3 2 3 0 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 2 0 N 1 0 0 1 0 1 1 1 0 2 1 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 0 0 N 0 0 0 0 0 0 0 0 0 0 0 0 2       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     103 5.6050                                                                             3 1 2 N 3 3 2 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 2 0 N 3 0 1 3 1 0 3 1 2 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             1 1 0 N 1 0 0 1 0 0 1 0 0 3 0 1 3       2                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 N 0 N 0 0 0 0 0 0 0 0 1 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     104 5.6050                                                                             0 0 3 N 3 2 2 3 3 3 3 3 2 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 1 1 N 0 0 1 1 1 3 0 2 2 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 1 0 N 1 1 1 1 1 0 1 0 0 2 1 0 2       1                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 1 0 N 1 1 0 0 0 1 0 1 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     105 5.6050                                                                             0 1 0 N 0 0 0 1 0 0 0 0 0 3 0 0 3       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 N 0 N 0 0 1 0 1 0 0 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 0 0 N 0 0 0 1 0 0 1 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     106 5.6050                                                                             2 2 0 N 3 1 1 1 0 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 0 0 N 3 0 0 1 0 1 0 1 0 3 1 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 1 0 N 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             N 0 0 N N 0 0 N 0 0 0 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     107 5.6050                                                                             1 1 1 N 3 2 3 3 3 2 1 2 1 3 2 2 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 1 0 N 2 1 1 2 3 0 0 1 0 2 1 0 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 0 0 N 1 0 0 1 0 0 0 0 0 0 0 0 3       1                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 0 0 N 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     108 5.6050                                                                             0 0 0 N 0 1 0 1 0 0 0 0 0 1 1 0 2       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 1 0 N 1 1 1 0 1 1 N 0 0 1 1 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 1 0 N 0 0 0 0 0 0 1 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 1 0 N 0 0 0 N N 0 0 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     109 5.6050                                                                             3 1 3 N 3 3 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             1 0 3 0 3 2 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 1 3 0 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 0 3 0 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 1 3 2 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 1 3 0 3 2 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 0 3 0 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 0 3 1 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 0 2 1 3 1 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 1 3 N 3 3 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 1 3 0 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 2 3 1 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 2 3 1 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             --                                                                               --                                                                               3 --                                                                               3 --                                                                               --                                                                               --                                                                               --                                                                               3 --                                                                               --                                                                               --                                                                               3 --                                                                               --                                                                               --      3                                                                              --                                                                             --                                                                             --                                                                               3 3 3 2    --                                                                        3                          1.1210                                                                             2 0 2 0 3 3 2 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 2 --                                                                               0 --                                                                               3 --                                                                               --                                                                               3 --                                                                               3 --                                                                               3 --                                                                               --                                                                               3 3       --                                                                             --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   3                                                                         --                         0.2803                                                                             0 1 2 0 3 1 0 --                                                                               1 3 1 3 1 2 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 0 --                                                                               0 --                                                                               2 --                                                                               --                                                                               3 --                                                                               3 --                                                                               2 --                                                                               --                                                                               3 3       --                                                                             --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   3                                                                         --                         0.2803                                                                             --                                                                               --                                                                               3 --                                                                               3 --                                                                               --                                                                               --                                                                               --                                                                               3 --                                                                               --                                                                               --                                                                               2 --                                                                               --                                                                               --      3                                                                              --                                                                             --                                                                             --                                                                               3 3 2 0    --                                                                        3                          0.2803                                                                             1 0 2 0 2 2 1 --                                                                               2 3 3 3   3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             2 0 0 0 3 0 0 --                                                                               2 3 3 3 2 3 3 3 3       3                                                                              --                                                                             --                                                                             3 --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             1 0 --                                                                               0 --                                                                               2 --                                                                               --                                                                               3 --                                                                               3 --                                                                               3 --                                                                               --                                                                               3 3       --                                                                             --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   3                                                                         --                         0.2803                                                                             0 0 0 0 3 0 0 --                                                                               2 3 2 3 0 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             --                                                                               --                                                                               3 --                                                                               3 --                                                                               --                                                                               --                                                                               --                                                                               3 --                                                                               --                                                                               --                                                                               3 --                                                                               --                                                                               --      3                                                                              --                                                                             --                                                                             --                                                                               3 3 0 0    --                                                                        3                          0.2803                                                                             1 N --                                                                               0 --                                                                               2 --                                                                               --                                                                               2 --                                                                               3 --                                                                               0 --                                                                               --                                                                               3 3       --                                                                             --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   3                                                                         --                         0.2803                                                                             --                                                                               --                                                                               3 --                                                                               3 --                                                                               --                                                                               --                                                                               --                                                                               3 --                                                                               --                                                                               --                                                                               3 --                                                                               --                                                                               --      3                                                                              --                                                                             --                                                                             --                                                                               3 3 1 2    --                                                                        2                          0.2803                                                                             2 0 2 N 3 2 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             2 1 1 0 2 1 2 --                                                                               1 3 3 3 2 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             1 0 3 0 2 2 3 --                                                                               2 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 N 0 0 3 0 3 --                                                                               3 3 3 3 2 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             3 0 3 0 3 0 2 --                                                                               1 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             2 0 3 0 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             1 1 0 0 3 1 2 --                                                                               3 3 3 3 2 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 0 0 0 3 0 1 --                                                                               1 3 1 3 1 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 0 3 0 3 0 2 --                                                                               2 3 3 3 1 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 0 3 0 3 2 2 --                                                                               3 3 3 3 2 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             1 1 3 1 3 3 3 --                                                                               2 3 3 3 1 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             1 1 3 0 3 2 2 --                                                                               1 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             2 1 2 0 3 3 2 --                                                                               2 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             2 2 1 1 3 2 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             1 0 1 1 3 0 0 --                                                                               1 3 2 3 2 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 1 1 0 3 0 2 --                                                                               2 3 3 3 2 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 0 3 0 3 2 3 --                                                                               2 3 2 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 1 1 0 3 0 2 --                                                                               2 3 3 3 1 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             2 0 1 0 3 3 2 --                                                                               2 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 0 0 0 0 0 0 --                                                                               0 3 3 3 1 2 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               1 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 0 1 0 2 0 2 --                                                                               1 2 3 3 1 3 2 3 3       3                                                                              --                                                                             --                                                                             --                                                                               2 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 0 0 0 2 0 0 --                                                                               0 3 1 2 0 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               2 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             1 N 0 0 2 1 1 --                                                                               2 2 3 2 1 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               2 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 0 0 0 2 0 0 --                                                                               1 1 2 3 0 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 0 0 0 2 0 0 --                                                                               0 3 1 2 0 2 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 0 0 0 1 0 2 --                                                                               1 0 0 3 1 2 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 1 1 0 0 3 1 --                                                                               1 2 1 2 0 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 N 0 0 3 0 N --                                                                               2 1 2 1 0 2 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               2 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 1 0 0 3 1 3 --                                                                               1 1 3 3 1 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               1 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             N 0 1 0 1 0 2 --                                                                               2 3 1 2 0 2 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               2 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 1 0 N 2 0 2 1 1 1 3 2 0 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             1 2 0 0 2 1 n --                                                                               1 3 3 3 0 2 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 1 0 0 1 0 0 --                                                                               1 2 2 3 1 2 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             1 0 1 1 1 3 1 --                                                                               2 3 3 3 2 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 1 0 0 3 0 0 --                                                                               1 1 2 3 0 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             1 0 0 0 0 0 1 --                                                                               1 3 1 3 1 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             1 1 0 0 3 0 1 --                                                                               1 3 3 3 2 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 1 0 1 3 1 0 --                                                                               1 1 3 3 1 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             --                                                                               --                                                                               1 --                                                                               1 --                                                                               --                                                                               --                                                                               --                                                                               3 --                                                                               --                                                                               --                                                                               3 --                                                                               --                                                                               --      3                                                                              --                                                                             --                                                                             --                                                                               3 3 0 0    --                                                                        3                          0.0701                                                                             --                                                                               --                                                                               2 --                                                                               3 --                                                                               --                                                                               --                                                                               --                                                                               3 --                                                                               --                                                                               --                                                                               3 --                                                                               --                                                                               --      3                                                                              --                                                                             --                                                                             --                                                                               3 3 0 0    --                                                                        3                          0.0701                                                                             --                                                                               --                                                                               2 --                                                                               3 --                                                                               --                                                                               --                                                                               --                                                                               3 --                                                                               --                                                                               --                                                                               3 --                                                                               --                                                                               --      3                                                                              --                                                                             --                                                                             --                                                                               3 3 1 0    --                                                                        3                          0.0701                                                                             0 0 0 0 2 0 1 --                                                                               0 0 0 2 0 3 3 3 3       2                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 0 0 0 0 0 0 --                                                                               0 1 1 1 0 1 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               2 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 0 0 0 1 0 0 --                                                                               0 0 2 0 0 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             N N --                                                                               0 --                                                                               0 --                                                                               --                                                                               0 --                                                                               1 --                                                                               0 --                                                                               --                                                                               3 3       --                                                                             --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   3                                                                         --                         0.0701                                                                             0 0 0 0 0 0 0 --                                                                               0 3 0 2 1 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 0 --                                                                               0 --                                                                               0 --                                                                               --                                                                               2 --                                                                               3 --                                                                               2 --                                                                               --                                                                               3 3       --                                                                             --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   3                                                                         --                         0.0701                                                                             0 N --                                                                               0 --                                                                               1 --                                                                               --                                                                               1 --                                                                               3 --                                                                               1 --                                                                               --                                                                               3 3       --                                                                             --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   3                                                                         --                         0.0175                                                                             0 1 0 0 0 0 0 --                                                                               0 1 0 1 0 0 1 2 3       1                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 0 0 0 0 0 0 --                                                                               0 1 0 0 0 1 3 1 3       2                                                                              --                                                                             --                                                                             --                                                                               2 --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 0 0 0 0 0 0 --                                                                               0 2 2 1 0 2 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             1 0 --                                                                               0 --                                                                               0 --                                                                               --                                                                               0 --                                                                               2 --                                                                               1 --                                                                               --                                                                               3 3       --                                                                             --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   3                                                                         --                         0.0175                                                                             0 N 0 0 0 0 1 --                                                                               1 0 1 0 0 0 1 0 3       0                                                                              --                                                                             --                                                                             --                                                                               2 --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             --                                                                               --                                                                               0 --                                                                               0 --                                                                               --                                                                               --                                                                               --                                                                               1 --                                                                               --                                                                               --                                                                               0 --                                                                               --                                                                               --      3                                                                              --                                                                             --                                                                             --                                                                               3 3 0 0    --                                                                        3                          0.0175                                                                             0 0 0 0 0 0 0 --                                                                               0 1 0 0 0 0 1 1 2       2                                                                              --                                                                             --                                                                             --                                                                               2 --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 0 --                                                                               0 --                                                                               0 --                                                                               --                                                                               0 --                                                                               0 --                                                                               0 --                                                                               --                                                                               3 2       --                                                                             --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   1                                                                         --                         0.0175                                                                             0 1 0 0 0 0 0 --                                                                               0 1 0 1 1 2 1 3 3       3                                                                              --                                                                             --                                                                             --                                                                               1 --                                                                               --                                                                               --   --                    0.0175                                                                             0 N --                                                                               0 --                                                                               1 --                                                                               --                                                                               0 --                                                                               1 --                                                                               0 --                                                                               --                                                                               2 3       --                                                                             --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   2                                                                         --                         0.0175                                                                             0 0 0 0 0 0 0 --                                                                               0 0 0 2 0 1 1 1 2       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 0 0 0 0 0 0 --                                                                               0 1 0 1 0 3 1 3 3       2                                                                              --                                                                             --                                                                             --                                                                               1 --                                                                               --                                                                               --   --                    0.0175                                                                             1 0 0 0 0 0 0 --                                                                               0 2 1 3 1 2 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             1 N 0 0 3 0 1 --                                                                               1 0 2 3 1 2 2 2 3       2                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 0 0 0 1 0 0 --                                                                               0 0 1 0 N 2 2 2 3       2                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 1 0 N 0 0 0 0 0 0 2 1 0 0 0 3 3       2                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 0 0 0 0 0 0 --                                                                               0 0 1 0 0 2 3 1 3       0                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 N 0 0 1 0 0 --                                                                               0 0 2 0 1 2 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               N --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             1 0 0 0 0 0 0 --                                                                               0 0 0 0 0 0 2 3 3       2                                                                              --                                                                             --                                                                             --                                                                               1 --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 N 0 0 N 0 2 --                                                                               2 0 1 0 0 2 3 1 3       1                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 0 0 0 0 0 0 --                                                                               0 1 0 2 0 2 1 2 3       2                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             N 0 0 0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 1       0                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 1 0 0 1 0 0 --                                                                               0 0 2 0 1 3 1 3 3       2                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 1 0 0 1 0 0 --                                                                               0 0 2 0 0 1 3 2 3       3                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             --                                                                               --                                                                               1 --                                                                               2 --                                                                               --                                                                               --                                                                               --                                                                               1 --                                                                               --                                                                               --                                                                               2 --                                                                               --                                                                               --      3                                                                              --                                                                             --                                                                             --                                                                               3 3 0 0    --                                                                        1                          0.0175                                                                             0 0 0 0 0 0 0 --                                                                               0 2 0 1 0 1 2 3 3       2                                                                              --                                                                             --                                                                             --                                                                               N --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 0 0 0 0 0 0 --                                                                               0 0 0 0 0 0 0 2 3       2                                                                              --                                                                             --                                                                             --                                                                               2 --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             --                                                                               --                                                                               0 --                                                                               0 --                                                                               --                                                                               --                                                                               --                                                                               0 --                                                                               --                                                                               --                                                                               0 --                                                                               --                                                                               --      3                                                                              --                                                                             --                                                                             --                                                                               0 3 0 0    --                                                                        0                          0.0175                                                                             0 0 0 0 0 0 0 --                                                                               1 0 0 0 0 2 1 1 3       1                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 0 0 0 0 0 0 --                                                                               0 0 0 0 0 0 0 1 2       1                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 N --                                                                               0 --                                                                               0 --                                                                               --                                                                               0 --                                                                               1 --                                                                               0 --                                                                               --                                                                               0 2       --                                                                             --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   1                                                                         --                         0.0087                                                                             0 1 0 0 0 0 1 --                                                                               2 0 0 0 0 1 0 0 2       0                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 0 --                                                                               0 --                                                                               0 --                                                                               --                                                                               0 --                                                                               0 --                                                                               0 --                                                                               --                                                                               0 2       --                                                                             --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   1                                                                         --                         0.0087                                                                             --                                                                               --                                                                               0 --                                                                               0 --                                                                               --                                                                               --                                                                               --                                                                               1 --                                                                               --                                                                               --                                                                               1 --                                                                               --                                                                               --      3                                                                              --                                                                             --                                                                             --                                                                               1 3 0 0    --                                                                        3                          0.0087                                                                             0 0 0 0 0 0 0 --                                                                               2 0 0 1 0 0 0 1 3       2                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             --                                                                               --                                                                               0 --                                                                               0 --                                                                               --                                                                               --                                                                               --                                                                               0 --                                                                               --                                                                               --                                                                               0 --                                                                               --                                                                               --      3                                                                              --                                                                             --                                                                             --                                                                               0 3 0 0    --                                                                        0                          0.0087                                                                             0 0 0 0 0 0 0 --                                                                               0 0 0 0 0 0 1 0 3       1                                                                              --                                                                             --                                                                             --                                                                               1 --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 0 0 0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 3       0                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             N 1 0 0 N 0 1 --                                                                               N N N 0 0 0 0 0 2       0                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 0 0 0 1 0 0 --                                                                               0 0 1 1 0 0 1 2 2       2                                                                              --                                                                             --                                                                             --                                                                               1 --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 0 0 N 0 0 0 0 0 0 0 0 0 0 0 1 3       2                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 0 0 0 N 0 0 --                                                                               0 0 0 2 0 1 0 0 3       1                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 0 0 0 0 0 0 --                                                                               0 0 0 1 0 0 0 2 3       0                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 0 0 0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 1       0                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 1 0 0 0 0 1 --                                                                               N 0 1 0 0 1 2 0 3       1                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0044                                                                             0 0 0 0 1 0 0 --                                                                               0 0 0 0 0 0 0 0 1       0                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0044                                                                             0 0 0 0 N 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0044                                                                             0 1 0 0 1 0 0 --                                                                               0 0 0 0 0 1 0 1 1       3                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0044                                                                             0 0 0 0 1 0 0 --                                                                               0 0 0 0 0 0 0 0 1       0                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0044                                                                             0 0 0 0 0 0 N --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0044                                                                             1 0 0 0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 3       1                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0044                                                                             --                                                                               --                                                                               0 --                                                                               1 --                                                                               --                                                                               --                                                                               --                                                                               0 --                                                                               --                                                                               --                                                                               0 --                                                                               --                                                                               --      2                                                                              --                                                                             --                                                                             --                                                                               2 0 0 0    --                                                                        0                          0.0044                                                                             0 0 --                                                                               0 --                                                                               0 --                                                                               --                                                                               0 --                                                                               0 --                                                                               0 --                                                                               --                                                                               3 2       --                                                                             --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   1                                                                         --                     110 5.6050                                                                             3 3 3 N 3 3 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             2 2 3 N 3 3 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             3 1 2 N 3 3 1 3 2 3 3 3 2 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             1 2 0 N 1 0 1 1 2 0 3 2 1 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 2 0 N 0 0 1 0 0 0 1 1 1 0 1 1 2       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 1 0 N 0 0 0 1 0 0 1 1 0 0 1 1 1       1                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     111 5.6050                                                                             3 2 3 N 3 3 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             2 1 3 N 3 2 2 3 3 3 3 3 2 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             1 0 3 N 2 1 2 2 0 1 3 2 0 1 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 N 0 N 0 0 0 0 0 0 0 0 0 0 0 1 3       1                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     112 5.6050                                                                             3 0 3 0 3 1 2 2 1 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             2 0 0 0 3 0 0 3 0 2 3 3 2 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 0 0 N 1 0 0 1 0 0 2 2 0 1 0 3 3       2                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 0 0 0 2 0 0 1 0 0 0 0 0 0 0 0 1       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 0 0 0 N 0 0 N 0 0 0 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     113 5.6050                                                                             0 2 1 0 3 0 0 --                                                                               1 3 2 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             1 0 0 0 0 0 0 --                                                                               0 0 1 3 0 0 0 2 3       3                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 0 0 0 0 0 0 --                                                                               0 0 0 1 0 0 0 0 1       0                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 1 0 0 0 0 0 --                                                                               0 0 0 1 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                     114 5.6050                                                                             3 0 3 N 3 3 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 0 3 N 3 1 1 3 1 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 0 0 N 1 0 0 1 0 2 3 1 0 3 3 3 3       2                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 0 0 N 0 0 0 1 1 0 1 1 1 0 1 0 2       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             1 0 0 N 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     115 5.6050                                                                             3 3 3 1 2 3 2 2 1 1 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             1 1 2 0 1 1 0 1 1 0 2 3 3 3 3 3 3       2                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 1 0 0 0 0 0 0 0 0 1 0 0 0 1 0 1       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 N 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 N 0 0 0 0 N 0 N 0 0 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     116 5.6050                                                                             3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 3 3 1 3 3 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             3 1 3 0 3 3 3 2 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             2 N 3 0 3 2 2 2 1 2 3 3 1 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 N 2 0 2 1 1 2 1 1 1 1 0 2 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 0 2 0 0 0 0 0 0 1 0 1 0 0 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     117 5.6050                                                                             3 2 3 2 3 3 3 2 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             1 0 1 0 2 1 1 2 0 2 2 3 3 3 3 1 3       1                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             1 1 0 0 0 0 0 0 0 0 0 1 0 0 0 0 2       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     118 5.6050                                                                             3 2 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 3 3 1 3 3 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 0 3 0 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             3 N 3 0 3 1 3 --                                                                               3 3 2 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             2 3 2 1 3 3 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             1 0 0 0 2 0 3 --                                                                               1 1 2 3 1 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             2 0 0 1 1 2 2 2 1 2 2 3 1 2 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 0 0 0 1 0 1 --                                                                               0 0 0 3 0 2 3 3 2       3                                                                              --                                                                             --                                                                             --                                                                               2 --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 N 0 0 1 0 0 1 0 1 1 1 0 1 2 2 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 0 0 0 0 0 0 1 0 0 1 0 0 1 0 0 1       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     119 5.6050                                                                             3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 2 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             3 1 3 0 3 3 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             1 N 3 0 2 1 3 3 2 3 1 3 2 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             1 1 2 0 2 0 1 1 1 1 1 3 0 3 2 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     120 5.6050                                                                             3 0 3 0 3 2 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 0 2 0 3 2 2 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 0 2 0 3 0 2 --                                                                               2 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 0 0 0 2 1 0 --                                                                               1 1 0 3 0 2 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 0 0 0 2 0 0 --                                                                               0 2 0 2 1 1 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               1 --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 0 0 0 1 0 0 --                                                                               0 0 0 1 0 1 1 3 3       2                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                     121 5.6050                                                                             3 2 3 3 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 1 3 1 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             2 0 3 0 3 2 2 --                                                                               2 3 3 3 2 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 1 3 0 3 2 2 --                                                                               1 3 2 3 0 2 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 1 1 0 2 0 0 --                                                                               1 0 1 1 1 1 2 2 3       1                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             1 1 0 0 1 0 1 --                                                                               0 0 1 0 0 1 0 0 3       0                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                     122 5.6050                                                                             3 2 3 1 3 3 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 0 3 0 3 3 3 3 2 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 0 2 0 3 1 1 3 2 3 3 3 2 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             1 0 0 0 0 0 1 1 0 1 3 3 1 2 2 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 0 0 0 1 0 0 2 0 0 1 0 0 0 2 0 3       1                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     123 5.6050                                                                             2 2 3 0 2 2 1 2 0 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             1 1 0 0 0 0 0 0 0 0 0 1 2 0 3 1 1       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 N 0 0 0 0 0 0 0 0 0 0 1 0 N 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     125 5.6050                                                                             2 0 3 0 3 3 2 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             1 1 3 0 2 1 2 2 2 2 2 3 1 1 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 1 2 N 2 1 2 1 1 2 3 1 1 2 3 2 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 0 1 0 0 0 0 0 0 1 0 0 0 0 0 0 2       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     126 5.6050                                                                             3 0 3 0 3 3 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 0 3 0 3 1 2 2 2 3 2 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             1 1 1 0 0 0 0 0 0 0 0 0 0 1 3 1 3       2                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             1 1 1 N 0 1 1 0 0 1 0 1 1 0 0 1 1       1                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     127 5.6050                                                                             2 0 1 1 1 1 0 1 0 2 3 3 3 3 3 3 3       1                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             1 N 0 0 0 0 0 0 1 0 1 1 1 2 2 0 2       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             N 0 0 0 0 0 0 0 N 0 0 0 1 0 1 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     128 5.6050                                                                             3 2 0 1 0 1 1 1 0 1 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             1 1 0 0 1 0 1 1 0 0 2 3 1 3 3 2 3       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 0 0 0 0 0 0 0 N 0 1 0 0 1 1 0 1       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 N 0 0 N 0 0 N 0 0 N 0 0 N 0 0 1       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 0 0 0 0 0 0 0 N 0 N 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     129 5.6050                                                                             3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 3 3 1 3 3 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             3 1 3 1 1 3 2 0 2 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             2 1 1 0 2 0 1 2 0 2 3 3 1 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0176                                                                             0 N 0 N 1 0 0 0 0 2 1 2 0 1 2 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             1 1 0 0 0 0 0 0 0 0 0 0 0 1 1 2 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     130 5.6050                                                                             3 2 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 1 3 0 3 3 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             2 2 3 1 3 3 3 3 3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 1 1 1 1 0 0 2 1 1 1 3 1 2 2 3 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 N 0 0 0 0 0 0 0 0 0 0 0 1 0 1 3       3                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 1       0                                                                              --                                                                             --                                                                             --                                                                               --                                                                               --                                                                               --                                                                               --   --                                                                        --                     131 5.6050                                                                             3 3 3 1 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 3 3 1 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             1 0 3 0 3 3 3 --                                                                               3 3 3 3 2 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             1 0 1 1 2 1 1 --                                                                               1 1 2 1 0 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               2 --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 0 N 0 N 0 0 --                                                                               2 0 0 1 0 2 1 3 3       3                                                                              --                                                                             --                                                                             --                                                                               N --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             0 0 0 0 0 0 0 --                                                                               0 0 1 0 0 1 0 0 2       2                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                     132 5.6050                                                                             3 3 3 2 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 0 3 1 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             1 0 3 0 3 2 2 --                                                                               2 1 3 2 1 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             1 0 0 0 1 3 1 --                                                                               1 0 1 1 0 2 3 3 3       1                                                                              --                                                                             --                                                                             --                                                                               2 --                                                                               --                                                                               --   --                                                                        --                     133 5.6050                                                                             3 1 3 1 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             2 0 3 0 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 1 1 0 0 1 0 --                                                                               0 2 2 3 0 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             N 1 0 0 0 0 0 --                                                                               0 0 1 2 0 1 1 0 3       1                                                                              --                                                                             --                                                                             --                                                                               2 --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 0 0 0 0 1 0 --                                                                               0 0 0 1 1 1 0 0 2       0                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0087                                                                             1 0 0 0 N N 0 --                                                                               0 0 0 0 0 0 0 0 1       0                                                                              --                                                                             --                                                                             --                                                                               N --                                                                               --                                                                               --   --                                                                        --                     134 5.6050                                                                             1 0 3 0 3 2 3 --                                                                               3 2 3 1 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 0 1 0 0 0 0 --                                                                               0 0 0 0 0 2 3 3 3       1                                                                              --                                                                             --                                                                             --                                                                               2 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 0 0 0 0 0 0 --                                                                               0 0 0 0 1 1 1 0 0       0                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                     135 5.6050                                                                             0 1 3 0 2 1 2 --                                                                               2 1 2 0 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 0 1 0 0 0 0 --                                                                               0 0 0 0 0 2 3 3 3       0                                                                              --                                                                             --                                                                             --                                                                               2 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 0 0 0 0 0 0 --                                                                               0 0 0 0 0 0 0 2 0       0                                                                              --                                                                             --                                                                             --                                                                               2 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 0 0 0 1 0 1 --                                                                               N 0 0 0 0 0 0 0 N       N                                                                              --                                                                             --                                                                             --                                                                               2 --                                                                               --                                                                               --   --                                                                        --                     136 5.6050                                                                             3 2 3 2 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             2 0 3 1 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             1 0 2 1 2 3 3 --                                                                               2 3 1 3 1 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 1 0 0 2 0 0 --                                                                               0 1 0 1 1 1 2 3 3       3                                                                              --                                                                             --                                                                             --                                                                               2 --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 0 1 N 0 0 0 --                                                                               0 1 0 1 0 0 0 0 3       1                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                     137 5.6050                                                                             3 3 3 3 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 2 3 1 3 2 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             3 1 3 0 3 1 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 0 3 0 1 0 1 --                                                                               2 3 3 3 1 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 0 2 0 0 0 0 --                                                                               1 2 3 2 0 3 2 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.0044                                                                             0 0 0 0 1 0 0 --                                                                               0 0 1 1 0 0 0 0 1       0                                                                              --                                                                             --                                                                             --                                                                               1 --                                                                               --                                                                               --   --                                                                        --                     139 5.6050                                                                             2 0 3 0 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             0 N 1 0 1 0 0 --                                                                               1 1 3 3 3 1 3 3 3       1                                                                              --                                                                             --                                                                             --                                                                               1 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             0 1 0 0 0 0 0 --                                                                               0 0 1 2 1 0 3 0 2       0                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 1 0 0 0 0 0 --                                                                               0 0 0 0 1 0 2 0 0       0                                                                              --                                                                             --                                                                             --                                                                               1 --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 0 0 0 0 1 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                     140 5.6050                                                                             3 1 3 1 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             3 2 3 1 3 3 3 --                                                                               3 3 3 3 3 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             2 2 3 0 3 3 3 --                                                                               3 3 3 3 3 2 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             3 2 2 0 3 1 2 --                                                                               1 2 3 3 1 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             1 1 1 0 2 0 0 --                                                                               0 1 2 1 0 1 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               2 --                                                                               --                                                                               --   --                                                                        --                     141 5.6050                                                                             3 2 3 0 3 3 3 --                                                                               3 3 3 3 2 3 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         1.1210                                                                             2 2 3 0 3 3 0 --                                                                               0 3 3 3 0 2 3 3 3       3                                                                              --                                                                             --                                                                             --                                                                               3 --                                                                               --                                                                               --   --                                                                        --                         0.2803                                                                             1 1 0 0 1 0 0 --                                                                               0 1 3 2 1 1 1 3 3       2                                                                              --                                                                             --                                                                             --                                                                               2 --                                                                               --                                                                               --   --                                                                        --                         0.0701                                                                             0 1 0 0 2 0 0 --                                                                               0 0 0 0 0 1 0 0 3       0                                                                              --                                                                             --                                                                             --                                                                               1 --                                                                               --                                                                               --   --                                                                        --                         0.0175                                                                             0 1 0 0 0 0 0 --                                                                               0 0 0 0 1 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               0 --                                                                               --                                                                               --   --                                                                        --                     __________________________________________________________________________

POST-EMERGENT HERBICIDE ACTIVITY ON PLANTS

Although, as has been stated above, the compounds of this invention exhibit predominantly pre-emergence activity in greenhouse testing, nevertheless many of these compounds are active post-emergent herbicides. The post-emergent activity is best seen on younger plants treated at the 11/2 to 2 leaf stage. In the tests which follow, larger and more developed plants were used.

The post-emergence herbicidal activity of compounds of this invention was demonstrated by greenhouse testing, and the results are shown in the following Table C. The post-emergent herbicidal activity index used in Table C is as follows:

    ______________________________________                                         Plant Response    Index                                                        ______________________________________                                          0-24% inhibition 0                                                            25-49% inhibition 1                                                            50-74% inhibition 2                                                            75-99% inhibition 3                                                            100% inhibition   4                                                            Species not planted                                                                              -- or a blank                                                Species planted, no data                                                                         N                                                            ______________________________________                                    

Top soil was placed in pans having holes in the bottom and compacted to a depth of 0.95 to 1.27 cm. from the top of the pan. A predetermined number of seeds of each of several dicotyledonous and monocotyledonous annual plant species and/or vegetative propagules for the perennial plant species were placed on the soil and pressed into the soil surface. The seeds and/or vegetative propagules were covered with soil and leveled. The pans were then placed on a bench in the greenhouse and watered as needed for germination and growth. After the plants reached the desired age (two to three weeks), each pan (except the control pans) was moved to a spraying chamber and sprayed by means of an atomizer. The spray solution or suspension contained about 0.4% by volume of an emulsifying agent and a sufficient amount of the candidate chemical to give an application rate of the active ingredient of 11.2 kg/ha while applying a total amount of solution or suspension equivalent to 1870 L/ha. The pans were returned to the greenhouse and watered as before and the injury to the plants as compared to those in control pans was observed at approximately 10-14 days (usually 11 days). The plant identifying codes in Table C are the same as above defined.

                                      TABLE C                                      __________________________________________________________________________     Herbicide Primary Postemergence                                                       Y A S D B M C V I W C C P R R                                                  e n e o y o o e n i a o e h h                                                  n b j b g g b l m b t l s q j                                           Compound                                                                              s g g r r l u e u w h q w g g                                           __________________________________________________________________________     1      0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           2      0 --                                                                               --                                                                               0 0 1 0 0 --                                                                               --                                                                               0 1 1 0 0                                           3      0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 2 0 0 0                                           4      0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           5      0 --                                                                               --                                                                               --                                                                               0 0 1 0 --                                                                               --                                                                               0 0 0 0 0                                           6      0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           7      0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           8      0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 N                                           9      0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           10     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           11     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           12     0 --                                                                               --                                                                               0 1 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           13     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 2 0 0 0                                           14     0 --                                                                               --                                                                               0 2 0 0 0 --                                                                               --                                                                               --                                                                               1 0 0 0                                           15     0 --                                                                               --                                                                               0 0 0 0 1 --                                                                               --                                                                               --                                                                               1 0 0 0                                           16     0 --                                                                               --                                                                               0 0 0 1 1 --                                                                               --                                                                               --                                                                               1 0 0 0                                           17     0 --                                                                               --                                                                               0 0 1 0 0 --                                                                               --                                                                               0 0 0 0 N                                           18     0 --                                                                               --                                                                               --                                                                               0 1 1 0 --                                                                               --                                                                               0 N 0 2 1                                           19     0 --                                                                               --                                                                               --                                                                               0 0 0 0 --                                                                               --                                                                               0 1 0 0 0                                           20     0 --                                                                               --                                                                               --                                                                               1 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           21     0 --                                                                               --                                                                               --                                                                               0 0 0 0 --                                                                               --                                                                               N 0 0 0 0                                           22     0 --                                                                               --                                                                               --                                                                               0 0 0 0 --                                                                               --                                                                               0 1 N 0 0                                           23     0 --                                                                               --                                                                               --                                                                               0 0 0 0 --                                                                               --                                                                               0 1 0 0 N                                           24     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 1 0 0 0                                           25     0 --                                                                               --                                                                               0 1 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           26     0 --                                                                               --                                                                               0 0 1 0 0 --                                                                               --                                                                               N 0 0 0 0                                           27     0 --                                                                               --                                                                               0 0 1 0 0 --                                                                               --                                                                               0 0 0 0 0                                           28     0 --                                                                               --                                                                               0 0 0 N 0 --                                                                               --                                                                               0 0 0 0 0                                           29     0 --                                                                               --                                                                               0 N 1 1 0 --                                                                               --                                                                               0 1 1 0 0                                           30     0 --                                                                               --                                                                               0 N 3 3 1 --                                                                               --                                                                               3 3 2 0 0                                           31     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               1 0 0 0 0                                           32     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               N 0 0 0 N                                           33     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           34     0 --                                                                               --                                                                               0 1 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           35     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           36     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 1 0 0 0                                           37     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           38     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           39     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 1 0 0 0                                           40     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           41     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 2 0 0 0                                           42     0 --                                                                               --                                                                               0 1 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           43     0 --                                                                               --                                                                               0 1 1 1 0 --                                                                               --                                                                               0 2 2 0 0                                           44     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           45     0 --                                                                               --                                                                               0 1 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           46     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           47     0 --                                                                               --                                                                               0 0 0 0 1 --                                                                               --                                                                               0 1 0 0 0                                           48     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           49     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           50     0 --                                                                               --                                                                               0 2 0 1 0 --                                                                               --                                                                               0 1 1 0 0                                           51     0 --                                                                               --                                                                               0 1 1 1 0 --                                                                               --                                                                               0 0 0 0 0                                           52     0 --                                                                               --                                                                               0 1 1 0 0 --                                                                               --                                                                               0 N 0 0 0                                           53     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           54     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           55     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           56     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           57     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           58     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           59     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           60     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           61     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 1 0 0 0                                           62     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 N 0 0 0                                           63     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           64     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           65     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           66     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 N 0 0 0                                           67     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           68     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           69     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 3 0 0 0                                           70     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           71     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           72     0 --                                                                               --                                                                               0 0 1 0 1 --                                                                               --                                                                               0 0 0 0 0                                           73     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           74     0 --                                                                               --                                                                               0 1 0 1 1 --                                                                               --                                                                               0 N 0 0 0                                           75     0 --                                                                               --                                                                               0 2 2 1 2 --                                                                               --                                                                               --                                                                               2 1 0 N                                           76     0 --                                                                               --                                                                               0 2 0 1 0 --                                                                               --                                                                               --                                                                               1 0 0 0                                           77     0 --                                                                               --                                                                               0 3 2 0 1 --                                                                               --                                                                               0 N N 0 0                                           78     0 --                                                                               --                                                                               0 0 1 1 2 --                                                                               --                                                                               0 N N 0 0                                           79     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 1 0 0 0                                           80     0 --                                                                               --                                                                               0 1 2 0 1 --                                                                               --                                                                               0 0 N 0 0                                           81     0 --                                                                               --                                                                               0 1 1 2 2 --                                                                               --                                                                               0 2 N 0 0                                           82     0 --                                                                               --                                                                               0 0 1 1 1 --                                                                               --                                                                               0 N N 0 0                                           83     0 --                                                                               --                                                                               0 0 0 1 1 --                                                                               --                                                                               2 0 0 0 --                                          84     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 N 0 0                                           85     0 0 0 0 0 0 0 1 1 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                          86     0 --                                                                               --                                                                               0 1 0 0 0 --                                                                               --                                                                               0 1 0 0 0                                           87     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           88     0 --                                                                               --                                                                               0 0 0 0 0 --                                                                               --                                                                               0 0 0 0 0                                           89     0 --                                                                               --                                                                               0 0 1 0 0 --                                                                               --                                                                               0 3 0 0 0                                           90     0 0 1 0 0 0 0 0 1 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                          91     0 --                                                                               --                                                                               0 0 1 0 0 --                                                                               --                                                                               0 3 0 0 0                                           92     0 --                                                                               --                                                                               0 1 2 0 1 --                                                                               --                                                                               0 3 0 0 0                                           93     0 0 2 0 2 2 1 2 2 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          94     0 2 1 0 2 2 2 2 2 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          95     0 0 0 0 0 0 0 0 0 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                          96     0 0 0 0 0 1 0 0 2 1 --                                                                               --                                                                               --                                                                               --                                                                               --                                          97     0 0 2 0 2 2 1 2 2 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          98     0 0 3 0 2 1 1 2 3 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          99     0 0 2 0 1 2 0 2 1 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          100    0 0 0 0 0 0 0 1 0 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                          101    0 0 2 0 0 0 0 0 2 1 --                                                                               --                                                                               --                                                                               --                                                                               --                                          102    0 0 2 0 2 2 2 2 2 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          103    0 0 2 0 2 2 2 2 2 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          104    0 0 1 0 2 2 2 2 1 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          105    0 0 0 0 0 0 0 0 0 1 --                                                                               --                                                                               --                                                                               --                                                                               --                                          106    0 0 2 0 0 0 0 0 0 1 --                                                                               --                                                                               --                                                                               --                                                                               --                                          107    0 0 0 0 0 0 1 2 0 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          108    0 0 0 0 0 0 0 0 0 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                          109    0 0 2 0 2 2 2 2 2 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          110    0 0 2 0 2 2 2 2 2 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          111    0 0 2 0 2 2 2 2 2 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          112    0 0 1 0 0 0 0 1 2 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          113    0 1 3 0 0 0 0 0 1 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          114    0 0 2 0 2 2 0 2 1 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          115    0 0 0 0 0 1 1 1 1 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                          116    0 0 2 0 2 1 0 1 2 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                          117    0 0 0 0 0 0 0 2 2 1 --                                                                               --                                                                               --                                                                               --                                                                               --                                          118    0 0 0 0 1 0 0 0 1 1 --                                                                               --                                                                               --                                                                               --                                                                               --                                          119    0 0 1 0 2 0 1 1 2 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          120    0 0 2 0 2 1 1 0 1 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          121    0 0 2 1 2 2 N 1 0 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          122    0 0 0 0 0 0 0 0 0 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                          123    0 0 0 0 0 0 0 0 0 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                          124    0 0 0 0 0 0 0 0 0 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                          125    0 0 1 0 1 0 0 0 0 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                          126    0 0 0 0 0 0 0 0 0 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                          127    0 0 0 0 0 0 0 0 0 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                          128    0 0 0 0 0 1 0 0 0 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                          129    0 0 2 0 2 0 2 1 2 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          130    0 1 0 0 2 1 1 0 2 1 --                                                                               --                                                                               --                                                                               --                                                                               --                                          131    0 0 0 0 0 0 0 0 0 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                          132    0 0 0 0 0 0 0 0 0 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                          133    0 0 0 0 0 0 0 0 0 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                          134    0 0 0 0 0 0 0 0 0 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                          135    0 0 0 0 0 0 0 0 0 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                          136    0 0 0 0 0 0 0 0 0 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                          137    0 1 2 0 2 1 2 1 0 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          138    0 0 0 0 0 1 1 2 2 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          139    0 0 1 0 0 2 0 1 2 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          140    0 0 2 0 1 2 2 2 2 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          141    0 0 2 0 0 1 1 2 2 2 --                                                                               --                                                                               --                                                                               --                                                                               --                                          __________________________________________________________________________

Compounds of this invention were also tested for herbicidal activity on weed plants in the presence of crop plants according to the following procedure:

Topsoil (silt loam) is sieved through a screen having 1.27 cm openings. In some of the tests the soil was mixed with fertilizer (1225 g/cu. m of 12/5/9 containing isobutylidene diurea), while in other tests the fertilizer was omitted. This mixture is steam sterilized and then placed in aluminum pans 6.985 cm deep having ten holes in the bottom each 0.635 cm in diameter. The soil mixture is compacted to a depth of 1.27 cm. from the top of the pan. A predetermined number of seeds of each of several dicotyledonous and monocotyledonous annual plant species and/or vegetative propagules for the perennial plant species are placed on the soil and pressed into the soil surface. The seeds and/or vegetative propagules are covered with 1.27 cm of a mixture of 50% topsoil and 50% of a mixture of Canadian sphagnum peat moss, vermiculite and a wetting agent. The pans are then placed on a capillary mat on a greenhouse bench and subirrigated as needed. After the plants reach the desired stage (9 to 14 days, 1 to 3 true leaf stage), each pan (except the control pans) is removed to a spraying chamber and sprayed by means of an atomizer, operating at a spray pressure of 170.3 kPa (10 psig) at the application rates noted in Table D. In the spray solution is an amount of an emulsifying agent mixture (35% butylamine salt of dodecylbenzenesulfonic acid and 65% tall oil condensed with ethylene oxide in the ratio of 11 mols of ethylene oxide/mol of tall oil) to give a spray solution or suspension. The spray solution or suspension contains a sufficient amount of the candidate chemical in order to give application rates of the active ingredient corresponding to those shown in Table D below while applying a total amount of solution or suspension equivalent to 1870 L/Ha (200 gallons/acre). The pans are returned to the greenhouse and watered as before and the injury to the plants as compared to the control pans is observed at approximately 10-14 days (usually 11 days).

In the following Table D the legends used to identify the plant species are the same as those used in the preceding Table B.

                                      TABLE D                                      __________________________________________________________________________               S C R C W M H J V W R G C D P B L G S C P C                                    o o a o i o e i e h i r o o r y a       r                                                                              u                                                                              o                                                                              e o                                Rate                                                                               b t p b b g s w l e c s r b m g c       f                                                                              b                                                                              l                                                                              s c                          Compound                                                                             kg/ha                                                                              e z e u w l e e e z e o n r i r g       t                                                                              e                                                                              q                                                                              w w                          __________________________________________________________________________     2     5.3808                                                                             3 3 3 4 3 2 4 4 4 0 1 2 2 0 3 3 3 3 --                                                                               --                                                                               --                                                                               --                               5.3808                                                                             3 2 2 4 2 1 3 3 2 0 0 1 2 0 3 2 3       2                                                                              --                                                                             --                                                                             --                                                                               --                               1.1210                                                                             1 2 0 0 2 1 2 2 2 0 0 0 2 0 2 1 3       2                                                                              --                                                                             --                                                                             --                                                                               --                               1.1210                                                                             1 1 1 0 2 1 2 2 2 0 0 0 2 0 2 1 3       1                                                                              --                                                                             --                                                                             --                                                                               --                               0.2803                                                                             2 1 1 0 1 2 2 2 2 0 0 0 0 0 0 0 3       0                                                                              --                                                                             --                                                                             --                                                                               --                               0.2803                                                                             2 2 2 0 1 1 2 1 2 0 0 0 0   0 0 3       0                                                                              --                                                                             --                                                                             --                                                                               --                               0.0701                                                                             0 0 1 0 0 1 1 0 1 0 0 0 0 0 0 0 3       0                                                                              --                                                                             --                                                                             --                                                                               --                               0.0701                                                                             1 0 1 0 0 2 1 0 1 0 0 0 0 0 0 0 3       0                                                                              --                                                                             --                                                                             --                                                                               --                         30    11.2100                                                                            1 --                                                                               --                                                                               2 2 2 1 --                                                                               1 0 0 1 2 0 0 1 1       1                                                                              1                                                                              2                                                                              1 --                               8.4075                                                                             1 --                                                                               --                                                                               2 1 1 2 --                                                                               2 0 0 1 1 0 0 1 1       1                                                                              1                                                                              1                                                                              1 --                               5.6050                                                                             1 --                                                                               --                                                                               1 1 1 1 --                                                                               1 0 0 1 1 0 0 1 2       2                                                                              1                                                                              1                                                                              1 --                               2.8025                                                                             1 --                                                                               --                                                                               1 1 1 1 --                                                                               1 0 0 1 2 0 1 2 2       2                                                                              1                                                                              1                                                                              1 --                               1.1210                                                                             1 --                                                                               --                                                                               0 1 1 1 --                                                                               1 0 0 0 1 0 0 0 0       0                                                                              1                                                                              0                                                                              0 --                               0.5605                                                                             0 --                                                                               --                                                                               0 1 1 1 --                                                                               1 0 0 0 1 0 0 0 1       1                                                                              0                                                                              0                                                                              0 --                         50    5.3808                                                                             3 3 3 3 3 3 3 3 3 0 0 1 2 0 2 2 3       2                                                                              --                                                                             --                                                                             --                                                                               --                               5.3808                                                                             3 3 3 3 3 3 3 3 3 0 0 2 1 0 1 3 3       2                                                                              --                                                                             --                                                                             --                                                                               --                               1.1210                                                                             2 2 3 2 2 2 2 2 2 0 1 0 2 0 1 1 3       1                                                                              --                                                                             --                                                                             --                                                                               --                               1.1210                                                                             2 3 3 2 3 2 3 3 3 0 1 0 1 0 2 1 3       1                                                                              --                                                                             --                                                                             --                                                                               --                               0.2803                                                                             1 2 2 1 3 2 2 2 2 0 0 0 0 0 1 0 3       1                                                                              --                                                                             --                                                                             --                                                                               --                               0.2803                                                                             1 2 3 1 3 2 3 2 3 0 0 0 0 1 1 0 3       1                                                                              --                                                                             --                                                                             --                                                                               --                               0.0701                                                                             0 1 1 0 1 1 2 2 2 0 0 0 0 0 0 0 3       0                                                                              --                                                                             --                                                                             --                                                                               --                               0.0701                                                                             0 1 2 0 1 1 2 2 2 0 0 0 0 0 0 0 2       0                                                                              --                                                                             --                                                                             --                                                                               --                         77    11.2100                                                                            2 --                                                                               --                                                                               3 3 3 1 --                                                                               2 1 0 1 3 0 1 3 3       2                                                                              2                                                                              2                                                                              2 --                               11.2100                                                                            3 --                                                                               --                                                                               3 2 3 3 --                                                                               3 0 0 1 3 0 2 3 3       3                                                                              2                                                                              3                                                                              1 --                               5.6050                                                                             2 --                                                                               --                                                                               2 2 2 0 --                                                                               2 0 0 1 2 0 0 2 3       1                                                                              2                                                                              2                                                                              0 --                               5.6050                                                                             3 --                                                                               --                                                                               0 3 2 3 --                                                                               3 0 0 0 2 1 0 2 3       2                                                                              1                                                                              3                                                                              0 --                               2.8025                                                                             1 --                                                                               --                                                                               1 2 2 3 --                                                                               3 0 0 1 2 0 0 1 3       1                                                                              2                                                                              3                                                                              0 --                               2.8025                                                                             1 --                                                                               --                                                                               1 1 2 1 --                                                                               2 0 0 1 2 0 0 2 3       1                                                                              2                                                                              2                                                                              0 --                               1.1210                                                                             1 --                                                                               --                                                                               1 0 1 2 --                                                                               3 0 0 0 0 0 0 0 2       0                                                                              1                                                                              3                                                                              0 --                               1.1210                                                                             1 --                                                                               --                                                                               0 1 1 0 --                                                                               1 0 0 1 1 0 0 0 2       0                                                                              1                                                                              2                                                                              0 --                         93    5.6050                                                                             3 2 3 3 0 3 3 3 3 0 0 2 3 0 0 2 3       1                                                                              --                                                                             --                                                                             --                                                                               --                               1.1210                                                                             2 0 3 2 0 2 3 3 2 0 0 0 3 0 0 0 3       0                                                                              --                                                                             --                                                                             --                                                                               --                               0.2803                                                                             1 0 2 0 0 2 3 2 0 0 0 0 3 0 0 0 2       0                                                                              --                                                                             --                                                                             --                                                                               --                               0.0701                                                                             0 0 0 0 0 0 1 2 0 0 0 0 0 0 0 0 N       0                                                                              --                                                                             --                                                                             --                                                                               --                         97    5.6050                                                                             0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                               1.1210                                                                             0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2       0                                                                              --                                                                             --                                                                             --                                                                               --                               0.2803                                                                             0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                               0.0701                                                                             0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                         98    5.6050                                                                             2 2 3 2 3 2 3 3 3 0 0 1 2 0 2 0 3       1                                                                              --                                                                             --                                                                             --                                                                               --                               1.1210                                                                             0 1 1 1 1 1 2 3 2 0 0 0 0 0 N 0 3       0                                                                              --                                                                             --                                                                             --                                                                               --                               0.2803                                                                             0 0 0 1 0 0 2 2 2 0 0 0 0 0 1 0 2       0                                                                              --                                                                             --                                                                             --                                                                               --                               0.0701                                                                             0 0 0 0 0 0 1 2 1 0 0 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                         103   5.6050                                                                             2 0 3 0 2 2 3 2 2 0 0 2 3 0 0 0 2       0                                                                              --                                                                             --                                                                             --                                                                               --                               1.1219                                                                             0 0 1 0 1 1 1 2 0 0 0 0 3 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                               0.2803                                                                             0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                               0.0701                                                                             0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               --                         113   5.6050                                                                             1 0 1 0 1 1 1 --                                                                               1 0 0 0 0 0 0 0 2       0                                                                              --                                                                             --                                                                             --                                                                               0                                1.1210                                                                             0 0 0 0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               N                                0.2803                                                                             0 0 0 0 0 0 0 --                                                                               0 0 0 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               0                          116   5.6050                                                                             2 1 3 2 2 2 2 --                                                                               2 0 0 1 2 0 0 1 2       1                                                                              --                                                                             --                                                                             --                                                                               2                                1.1210                                                                             2 1 3 2 2 2 2 --                                                                               3 0 0 0 2 0 0 0 2       0                                                                              --                                                                             --                                                                             --                                                                               2                                0.2803                                                                             1 0 2 1 1 1 1 --                                                                               2 0 0 0 0 0 0 0 2       0                                                                              --                                                                             --                                                                             --                                                                               1                                0.0701                                                                             1 0 1 0 1 2 1 --                                                                               1 0 0 N 0 0 0 0 2       0                                                                              --                                                                             --                                                                             --                                                                               0                          137   5.6050                                                                             2 2 3 3 2 2 3 --                                                                               2 0 1 2 1 1 1 2 3       2                                                                              --                                                                             --                                                                             --                                                                               3                                1.1210                                                                             2 2 3 1 3 1 3 --                                                                               3 0 1 0 0 1 0 2 3       2                                                                              --                                                                             --                                                                             --                                                                               3                                0.2803                                                                             0 1 3 0 0 1 1 --                                                                               3 0 0 0 0 0 0 1 3       2                                                                              --                                                                             --                                                                             --                                                                               2                          140   5.6050                                                                             2 1 3 3 1 2 3 --                                                                               3 0 0 0 2 0 0 0 3       0                                                                              --                                                                             --                                                                             --                                                                               3                                1.1210                                                                             2 1 3 3 31                                                                               2 3 --                                                                               2 0 0 0 1 0 0 0 2       0                                                                              --                                                                             --                                                                             --                                                                               2                                0.2803                                                                             1 1 3 1 0 2 3 --                                                                               3 0 0 0 2 0 0 0 2       0                                                                              --                                                                             --                                                                             --                                                                               2                          151   5.6050                                                                             2 1 3 2 1 2 1 --                                                                               2 0 0 0 2 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               1                                1.1210                                                                             1 1 3 2 0 1 2 --                                                                               2 0 0 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               0                                0.2803                                                                             0 1 2 1 0 1 1 --                                                                               1 0 0 0 0 0 0 0 0       0                                                                              --                                                                             --                                                                             --                                                                               0                          __________________________________________________________________________

As can be seen from the data above, some of the compounds appear to be quite safe on certain crops and can thus be used for selective control of weeds in these crops.

The herbicidal compositions of this invention, including concentrates which require dilution prior to application, may contain at least one active ingredient and an adjuvant in liquid or solid form. The compositions are prepared by admixing the active ingredient with an adjuvant including diluents, extenders, carriers, and conditioning agents to provide compositions in the form of finely-divided particulate solids, granules, pellets, solutions, dispersions or emulsions. Thus, it is believed that the active ingredient could be used with an adjuvant such as a finely-divided solid, a liquid of organic origin, water, a wetting agent, a dispersing agent, an emulsifying agent or any suitable combination of these.

Suitable wetting agents are believed to include alkyl benzene and alkyl naphthalene sulfonates, sulfated fatty alcohols, amines or acid amides, long chain acid esters of sodium isothionate, esters of sodium sulfosuccinate, sulfated or sulfonated fatty acid esters, petroleum sulfonates, sulfonated vegetable oils, ditertiary acetylenic glycols, polyoxyethylene derivatives of alkylphenols (particularly isooctylphenol and nonylphenol) and polyoxyethylene derivatives of the mono-higher fatty acid esters of hexitol anhydrides (e.g., sorbitan). Preferred dispersants are methyl, cellulose, polyvinyl alcohol, sodium lignin sulfonates, polymeric alkyl naphthalene sulfonates, sodium naphthalene sulfonate, and polymethylene bisnaphthalene sulfonate.

Wettable powders are water-dispersible compositions containing one or more active ingredients, an inert solid extender and one or more wetting and dispersing agents. The inert solid extenders are usually of mineral origin such as the natural clays, diatomaceous earth and synthetic minerals derived from silica and the like. Examples of such extenders include kaolinites, attapulgite clay and synthetic magnesium silicate. The wettable powders compositions of this invention usually contain from above 0.5 to 60 parts (preferably from 5-20 parts) of active ingredient, from about 0.25 to 25 parts (preferably 1-15 parts) of wetting agent, from about 0.25 to 25 parts (preferably 1.0-15 parts) of dispersant and from 5 to about 95 parts (preferably 5-50 parts) of inert solid extender, all parts being by weight of the total composition. Where required, from about 0.1 to 2.0 parts of the solid inert extender can be replaced by a corrosion inhibitor or anti-foaming agent or both.

Other formulations include dust concentrates comprising from 0.1 to 60% by weight of the active ingredient on a suitable extender; these dusts may be diluted for application at concentrations within the range of from about 0.1-10% by weight.

Aqueous suspensions or emulsions may be prepared by stirring a nonaqueous solution of a water-insoluble active ingredient and an emulsification agent with water until uniform and then homogenizing to give stable emulsion of very finely-divided particles. The resulting concentrated aqueous suspension is characterized by its extremely small particle size, so that when diluted and sprayed, coverage is very uniform. Suitable concentrations of these formulations contain from about 0.1-60% preferably 5-50% by weight of active ingredient, the upper limit being determined by the solubility limit of active ingredient in the solvent.

Concentrates are usually solutions of active ingredient in water-immiscible or partially water-immiscible solvents together with a surface active agent. Suitable solvents for the active ingredient of this invention include N,-N-dimethylformamide, dimethylsulfoxide, N-methyl-pyrrolidone, hydrocarbons, and water-immiscible ethers, esters, or ketones. However, other high strength liquid concentrates may be formulated by dissolving the active ingredient in a solvent then diluting, e.g., with kerosene, to spray concentration.

The concentrate compositions herein generally contain from about 0.1 to 95 parts (preferably 5-60 parts) active ingredient, about 0.25 to 50 parts (preferably 1-25 parts) surface active agent and where required about 4 to 94 parts solvent, all parts being by weight based on the total weight of emulsifiable oil.

Granules are physically stable particulate compositions comprising at least one active ingredient adhered to or distributed through a basic matrix of an inert, finely-divided particulate extender. In order to aid leaching of the active ingredient from the particulate, a surface active agent such as those listed hereinbefore can be present in the composition. Natural clays, pyrophyllites, illite, and vermiculite are examples of operable classes of particulate mineral extenders. The preferred extenders are the porous, absorptive, preformed particules such as preformed and screened particulate attapulgite or heat expanded, particulate vermiculite and the finely-divided clays such as kaolin clays, hydrated attapulgite or bentonitic clays. These extenders are sprayed or blended with the active ingredient to form the herbicidal granules.

The granular compositions of this invention may contain from about 0.1 to about 30 parts by weight of active ingredient per 100 parts by weight of clay and 0 to about 5 parts by weight of surface active agent per 100 parts by weight of particulate clay.

The compositions of this invention can also contain other additaments, for example, fertilizers, other herbicides, other pesticides, safeners and the like used as adjuvants or in combination with any of the above-described adjuvants. Chemicals useful in combination with the active ingredients of this invention included, for example, triazines, ureas, carbamates, acetamides, acetanilides, uracils, acetic acid or phenol derivatives, thiolcarbamates, triazoles, benzoic acids, nitriles, biphenyl ethers and the like, such as:

HETEROCYCLIC NITROGEN/SULFUR DERIVATIVES

2-Chloro-4-ethylamino-6-isopropylamino-s-triazine

2-Chloro-4,6-bis(isopropylamino)-s-triazine

2-Chloro-4,6-bis(ethylamino)-s-triazine

3-Isopropyl-1H-2,1,3-benzothiadiazin-4-(3H)-one 2,2 dioxide

3-Amino-1,2,4-triazole

6,7-Dihydrodipyrido(1,2-d:α',1'-c)-pyrazidiinium salt

5-Bromo-3-isopropyl-6-methyluracil 1,1'-dimethyl-4,4'-bipyridinium

2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-3-quinolinecarboxylic acid

Isopropylamine salt of 2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinic acid

Methyl 6-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-m-toluate and methyl 2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-p-toluate

Ureas

N-(4-chlorophenoxy) phenyl-N,N-dimethylurea

N,N-dimethyl-N'-(3-chloro-4-methylphenyl)urea

3-(3,4-Dichlorophenyl)-1,1-dimethylurea

1,3-Dimethyl-3-(2-benzothiazolyl)urea

3-(p-Chlorophenyl)-1,1-dimethylurea

1-Butyl-3-(3,4-dichlorophenyl)-1-methylurea

2-Chloro-N[(4-methoxy-6-methyl-3,5-triazin-2-yl)aminocarbonyl]-benzenesulfonamide

Methyl 2-(((((4,6-dimethyl-2-pyrimidinyl)amino)carbonyl)amino)sulfonyl)benzoate

Ethyl 2-[methyl 2-(((((4,6-dimethyl-2-pyrimidinyl)amino)carbonyl)amino)sulfonyl)]benzoate

Methyl-2((4,6-dimethoxy pyrimidin-2-yl)aminocarbonyl)amino sulfonyl methyl)benzoate

Methyl 2-(((((4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino)carbonyl)amino)sulfonyl)benzoate

Carbamates/Thiolcarbamates

2-Chloroallyl diethyldithiocarbamate

S-(4-chlorobenzyl)N,N-diethylthiolcarbamate

Isopropyl N-(3-chlorophenyl)carbamate

S-2,3-dichloroallyl N,N-diisopropylthiolcarbamate

S-N,N-dipropylthiolcarbamate

S-propyl N,N-dipropylthiolcarbamate

S-2,3,3-trichloroallyl N,N-diisopropylthiolcarbamate

Acetamides/Acetanilides/Anilines/Amides

2-Chloro-N,N-diallylacetamide

N,N-dimethyl-2,2-diphenylacetamide

N-(2,4-dimethyl-5-[[(trifluoromethyl)sulfonyl]amino]phenyl]acetamide N-Isopropyl-2-chloroacetanilide

2',6'-Diethyl-N-methoxymethyl-2-chloroacetanilide

2'-Methyl-6'-ethyl-N-(2-methoxypropyl-2-yl)-2-chloroacetanilide

α,α,α-Trifluoro-2,6-dinitro-N,N-dipropyl-p-toluidine

N-(1,1-dimethylpropynyl)-3,5-dichlorobenzamide

Acids/Esters/Alcohols

2,2-Dichloropropionic acid

2-Methyl-4-chlorophenoxyacetic acid

2,4-Dichlorophenoxyacetic acid

Methyl-2-[4-(2,4-dichlorophenoxy)phenoxy]propionate

3-Amino-2,5-dichlorobenzoic acid

2-Methoxy-3,6-dichlorobenzoic acid

2,3,6-Trichlorophenylacetic acid

N-1-naphthylphthalamic acid

Sodium 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoate

4,6-Dinitro-o-sec-butylphenol N-(phosphonomethyl)glycine and its salts.

Butyl 2-[4-[(5-(trifluoromethyl)-2-pyridinyl)oxy]-phenoxy]-propanoate

Ethers

2,4-Dichlorophenyl-4-nitrophenyl ether

-Chloro-α,α,α-trifluoro-p-tolyl-3-ethoxy-4-nitrodiphenyl ether

5-(2-chloro-4-trifluoromethylphenoxy)-N-methyl sulfonyl 2-nitrobenzamide

1'-(Carboethoxy)ethyl 5-[2-chloro-4-(trifluoro methyl)phenoxy]-2-nitrobenzoate

Miscellaneous

2,6-Dichlorobenzonitrile

Monosodium acid methanearsonate

Disodium methanearsonate

2-(2-chlorophenyl)methyl-4,4-dimethyl-3-isoxazolidinone

7-oxabicyclo(2.2.1)heptane, 1-methyl-4-(1-methyl ethyl)-2-(2-methylphenylmethoxy)-,exo- Fertilizers

useful in combination with the active ingredients include, for example ammonium nitrate, urea, potash and superphosphate. Other useful additaments include materials in which plant organisms take root and grow such as compost, manure, humus, sand and the like.

Herbicidal formulations of the types described above are exemplified in several illustrative embodiments below.

    ______________________________________                                                              Weight Percent                                            ______________________________________                                               I. Emulsifiable Concentrates                                             A.    Compound of Example No. 2                                                                           11.0                                                      Free acid of complex organic                                                                        5.59                                                      phosphate or aromatic or                                                       aliphatic hydrophobe base                                                      (e.g., GAFAC RE-610, registered                                                trademark of GAF Corp                                                          Polyoxyethylene/polyoxypropylene                                                                    1.11                                                      block copolymer with butanol                                                   (e.g., Tergitol XH, registered                                                 trademark of Union Carbide Corp.)                                              Phenol               5.34                                                      Monochlorobenzene    76.96                                                                          100.00                                              B.    Compound of Example No. 13                                                                          25.00                                                     Free acid of complex organic                                                                        5.00                                                      phosphate of aromatic or                                                       aliphatic hydrophobe base                                                      (e.g., GAFAC RE-610)                                                           Polyoxyethylene/polyoxypropylene                                                                    1.60                                                      block copolymer with butanol                                                   (e.g., Tergitol XH)                                                            Phenol               4.75                                                      Monochlorobenzene    63.65                                                                          100.00                                                    II. Flowables                                                            A.    Compound of Example No. 23                                                                          25.00                                                     Methyl cellulose     0.3                                                       Silica Aerogel       1.5                                                       Sodium lignosulfonate                                                                               3.5                                                       Sodium N-methyl-N-oleyl taurate                                                                     2.0                                                       Water                67.7                                                                           100.00                                              B.    Compound of Example No. 17                                                                          45.0                                                      Methyl cellulose     .3                                                        Silica aerogel       1.5                                                       Sodium lignosulfonate                                                                               3.5                                                       Sodium N-methyl-N-oleyl taurate                                                                     2.10                                                      Water                47.7                                                                           100.00                                                    III. Wettable Powders                                                    A.    Compound of Example No. 4                                                                           25.0                                                      Sodium lignosulfonate                                                                               3.0                                                       Sodium N-methyl-N-oleyl-taurate                                                                     1.0                                                       Amorphous silica (synthetic)                                                                        71.0                                                                           100.00                                              B.    Compound of Example 20                                                                              80.00                                                     Sodium dioctyl sulfosuccinate                                                                       1.25                                                      Calcium lignosulfonate                                                                              2.75                                                      Amorphous silica (synthetic)                                                                        16.00                                                                          100.00                                              C.    Compound of Example No. 5                                                                           10.0                                                      Sodium lignosulfonate                                                                               3.0                                                       Sodium N-methyl-N-oleyl-taurate                                                                     1.0                                                       Kaolinite clay       6.0                                                                            100.00                                                    IV. Dusts                                                                A.    Compound of Example No. 12                                                                          2.0                                                       Attapulgite          98.0                                                                           100.00                                              B.    Compound of Example No. 9                                                                           60.0                                                      Montmorillonite      40.0                                                                           100.00                                              C.    Compound of Example No. 53                                                                          30.0                                                      Ethylene glycol      1.0                                                       Bentonite            69.0                                                                           100.0                                               D.    Compound of Example No. 61                                                                          1.0                                                       Diatomaceous earth   99.0                                                                           100.00                                                    V. Granules                                                              A.    Compound of Example No. 51                                                                          15.0                                                      Granular attapulgite (20/40 mesh)                                                                   85.0                                                                           100.00                                              B.    Compound of Example No. 69                                                                          30.0                                                      Diatomaceous earth (20/40)                                                                          70.0                                                                           100.00                                              C.    Compound of Example No. 57                                                                          1.0                                                       Ethylene glycol      5.0                                                       Methylene blue       0.1                                                       Pyrophyllite         93.9                                                                           100.00                                              D.    Compound of Example No. 45                                                                          5.0                                                       Pyrophyllite (20/40) 95.0                                                                           100.00                                              ______________________________________                                    

When operating in accordance with the present invention, effective amounts of the compounds of this invention are applied to the soil containing the seeds, or vegetative propagules or may be incorporated into soil media in any convenient fashion. The application of liquid and particulate solid compositions to the soil can be carried out by conventional methods, e.g., power dusters, boom and hand sprayers and spray dusters. The compositions can also be applied from airplanes as a dust or a spray because of their effectiveness at low dosages.

The exact amount of active ingredient to be employed is dependent upon various factors, including the plant species and stage of development thereof, the type and condition of soil, the amount of rainfall and the specific compounds employed. In selective pre-emergence application or to the soil, a dosage of from about 0.02 to about 11.2 kg/ha, preferably from about 0.1 to about 5.60 kg/ha, is usually employed. Lower or higher rates may be required in some instances. One skilled in the art can readily determine from this specification, including the above examples, the optimum rate to be applied in any particular case.

The term "soil" is employed in its broadest sense to be inclusive of all conventional "soils" as defined in Webster's New International Dictionary, Second Edition, Unabridged (1961). Thus, the term refers to any substance or medium in which vegetation may take root and grow, and includes not only earth but also compost, manure, muck, humus, sand, and the like, adapted to support plant growth.

While the illustrative embodiments of the invention have been described with particularity, it will be understood that various other modifications will be apparent to and can be readily made by those skilled in the art without departing from the spirit and scope of the invention. Accordingly, it is not intended that the scope of the claims appended hereto be limited to the examples and descriptions set forth hereinabove but rather that the claims be construed as encompassing all the features of patentable novelty which reside in the present invention, including all features which would be treated as equivalents thereof by those skills in the art to which the invention pertains. 

What is claimed is:
 1. A compound represented by the formula ##STR10## wherein: R₁ is fluorinated methyl, chlorofluorinated methyl or fluorinated ethyl;R₂ is hydrogen, C1-C7 alkyl, trichloromethyl, C2-C8 cyanoalkyl, C3-C7 alkenyl, or C3-C7 alkynyl; R is C1-C6 straight or branched alkyl, C1-C7 haloalkyl, C2-C14 alkylthioalkyl, C2-C14 alkoxyalkyl, C2-C8 carboxyalkyl, C3-C4 cycloalkyl, or cyclopropylmethyl; one of X and Y is selected from ##STR11## where Z₁ is oxygen or NR₃ where R₃ is lower alkyl and where Z is hydrogen; halogen; hydroxy; C1-C7 alkoxy; C1-C7 haloalkoxy; C3-C7 alkynyloxy; C1-C7 alkylthio; NR₄ R₅ where R₄ and R₅ are independently hydrogen or lower alkyl; acetylamino; C1-C7 hydroxyalkyl; C1-C7 haloalkyl; and C2-C8 alkoxymethyleneamino; the other of X and Y is ##STR12## where Z₁ is oxygen or NR₃ where R₃ is lower alkyl; and where Z' is 1-imidazolyl; 1,2,4-triazolyl; 1-pyrrolidinyl; 1-piperidinyl; 1-azetidinyl; 4-morpholinyl; 4-thiomorpholinyl; 3-thiazolidinyl; 1-aziridinyl; hexahydro-1-azepinyl; and 2-isoxazolidinyl.
 2. A compound according to claim 1 wherein R₁ is CF₃ and R₂ is CH₃.
 3. A compound according to claim 2 wherein R is C₁ -C₄ straight or branched chain alkyl.
 4. A compound according to claim 2 wherein R is selected from cyclobutyl and cyclopropylmethyl.
 5. A compound according to claim 3 wherein X is methoxycarbonyl.
 6. A compound according to claim 3 wherein X is methylthiocarbonyl.
 7. An herbicidal composition comprising an adjuvant and an effective amount of a compound represented by the formula ##STR13## wherein: R₁ is fluorinated methyl, chlorofluorinated methyl or fluorinated ethyl;R₂ is hydrogen, C1-C7 alkyl, trichloromethyl, C2-C8 cyanoalkyl, C3-C7 alkenyl, or C3-C7 alkynyl; R is C1-C6 straight or branched alkyl, C1-C7 haloalkyl, C2-C14 alkylthioalkyl, C2-C14 alkoxyalkyl, C2-C8 carboxyalkyl, C3-C4 cycloalkyl, or cyclopropylmethyl; one of X and Y is selected from ##STR14## where Z₁ is oxygen or NR₃ where R₃ is lower alkyl and where Z is hydrogen; halogen; hydroxy; C1-C7 alkoxy; C1-C7 haloalkoxy; C3-C7 alkynyloxy: C₁ -C7 alkylthio; NR₄ R₅ where R₄ and R₅ are independently hydrogen or lower alkyl; acetylamino; C1-C7 hydroxyalkyl; C1-C7 haloalkyl; and C2-C8 alkoxymethyleneamino; the other of X and Y is ##STR15## where Z₁ is oxygen or NR₃ where R₃ is lower alkyl; and where Z' is 1-imidazolyl; 1,2,4-triazolyl; 1-pyrrolidinyl; 1-piperidinyl; 1-azetidinyl; 4-morpholinyl; 4-thiomorpholinyl; 3-thiazolidinyl; 1-aziridinyl; hexahydro-1-azepinyl; and 2-isoxazolidinyl.
 8. A composition according to claim 7 wherein R₁ is CF₃ and R₂ is CH₃.
 9. A composition according to claim 8 wherein R is C₁ -C₄ straight or branched chain alkyl.
 10. A composition according to claim 8 wherein R is selected from cyclobutyl and cyclopropylmethyl.
 11. A composition according to claim 9 wherein X is methoxycarbonyl.
 12. A composition according to claim 9 wherein X is methylthiocarbonyl.
 13. A method of controlling undesirable vegetation comprising applying to the soil an effective herbicidal amount of a compound represented by the formula ##STR16## wherein: R₁ is fluorinated methyl, chlorofluorinated methyl or fluorinated ethyl;R₂ is hydrogen, C1-C7 alkyl, trichloromethyl, C2-C8 cyanoalkyl, C3-C7 alkenyl, or C3-C7 alkynyl; R is C1-C6 straight or branched alkyl, C1-C7 haloalkyl, C2-C14 alkylthioalkyl, C2-C14 alkoxyalkyl, C2-C8 carboxyalkyl, C₃ -C4 cycloalkyl, or cyclopropylmethyl; one of X and Y is selected from ##STR17## where Z₁ is oxygen or NR₃ where R₃ is lower alkyl and where Z is hydrogen; halogen; hydroxy; C1-C7 alkoxy; C1-C7 haloalkoxy; C₃ -C7 alkynyloxy: C1-C7 alkylthio; NR₄ R₅ where R₄ and R₅ are independently hydrogen or lower alkyl; acetylamino; C1-C7 hydroxyalkyl; C1-C7 haloalkyl; and C2-C8 alkoxymethyleneamino; the other of X and Y is ##STR18## where Z₁ is oxygen or NR₃ where R₃ is lower alkyl; and where Z' is 1-imidazolyl; 1,2,4-triazolyl; 1-pyrrolidinyl; 1-piperdinyl; 1-azetidinyl; 4-morpholinyl; 4-thiomorpholinyl; 3-thiazolidinyl; 1-aziridinyl; hexahydro-1-azepinyl; and 2-isoxazolidinyl.
 14. A method according to claim 13 wherein R₁ is CF₃ and R₂ is CH₃.
 15. A method according to claim 14 wherein R is C₁ -C₄ straight or branched chain alkyl.
 16. A method according to claim 14 wherein R is selected from cyclobutyl and cyclopropylmethyl.
 17. A method according to claim 15 wherein X is methoxycarbonyl.
 18. A method according to claim 15 wherein X is methylthiocarbonyl. 